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Search Results - zhong-yuan+li
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Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024
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Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
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Inventor(s):
Hongmin Li
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
SPACX: A Hardware and Algorithm Co-Optimized Photonic Deep Neural Network Computing Architecture
SPACX- A silicon-based Photonic accelerator for DNN Chiplets architecture The continuous increase in size and complexity of deep neural network (DNN) models leads to rapidly increasing demand for computing capacity which has outpaced the scaling capability of conventional monolithic chips. Chiplet-based DNN accelerators have emerged as a promising...
Published: 7/30/2024
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Inventor(s):
Yuan Li
,
Ahmed Louri
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Computers Electronics & Software
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Technology Classifications > Computers Electronics & Software > Artificial Intelligence
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Technology Classifications > Computers Electronics & Software > Processing Chips
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Technology Classifications > Computers Electronics & Software > Computing Architecture
Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024
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Inventor(s):
Hongmin Li
,
subodh samrat
,
Zhong Li
,
Jia Zhou
,
Jimin Xu
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024
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Inventor(s):
Hongmin Li
,
Zhong Li
,
Qing-yu Zhang
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors
This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...
Published: 7/25/2024
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Inventor(s):
Menghang Xia
,
Ruili Huang
,
Laura Kramer
,
Zhong Li
,
Hongmin Li
Keywords(s):
Activity
,
Antiflaviviral
,
Compositions
,
PHARMACEUTICAL
,
VLXXXX
,
WIXXXX
,
WKXXXX
,
XHXXXX
Category(s):
TherapeuticArea > Infectious Disease
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Application > Therapeutics
,
ResearchProducts > Research Equipment
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Application > Research Materials
Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses
Rabies occurs in more than 150 countries and territories, resulting in at least 55,000 human deaths per year worldwide according to World Health Organization estimates. Rabies is a vaccine-preventable viral disease caused by numerous lyssaviruses that are found in a variety of animal species throughout the world. Rabies virus infects the central nervous...
Published: 7/25/2024
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Inventor(s):
Yu Li
Keywords(s):
assay
,
DA4XXX
,
DDXXXX
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Diagnostics
,
LYSSAVIRUSES
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Modified
,
NCEZID
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NCEZID-DHCPP
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Non-rabies
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Probe
,
rabies
,
REAL-TIME
,
RT-PCR
,
VLXXXX
,
VOXXXX
,
WBXXXX
,
WGXXXX
,
WHXXXX
,
WIXXXX
,
XEXXXX
,
YBXXXX
,
YGXXXX
Category(s):
Collaboration Sought > Collaboration
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Collaboration Sought > Licensing
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Application > Occupational Safety and Health
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TherapeuticArea > Infectious Disease
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Application > Consumer Products
,
Application > Therapeutics
,
Application > Research Materials
,
Application > Diagnostics
Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samples
CDC researchers have developed an assay for detection and diagnosis of poxviruses within clinical samples or from lab culture-systems. The assay specifically targets chordopoxviruses (except avipoxviruses) for PCR-based identification; an improvement upon the current standard of cell culturing methodologies. Individual chordopoxvirus species can cause...
Published: 7/25/2024
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Inventor(s):
Inger Damon
,
Hui Zhao
,
Yu Li
Keywords(s):
ASSAYS
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CDC Docket Import
,
CDC Docket Import CDC Prosecuting
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CHORDOPOXVIRUSES
,
DA4BXX
,
DA4XXX
,
DAXXXX
,
diagnostic
,
DXXXXX
,
OID-NCEZID-DHCPP
,
VLXXXX
,
VOXXXX
,
WBXXXX
,
WFXXXX
,
WIXXXX
,
WMXXXX
,
XCXXXX
,
XEXXXX
,
YBXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Occupational Safety and Health
,
Application > Therapeutics
,
TherapeuticArea > Infectious Disease
,
Application > Consumer Products
,
Application > Diagnostics
,
Application > Research Materials
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
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Inventor(s):
Leilei Peng
,
Yu Li
,
Han Zhang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Synthesis of Optically Active Indoline Derivatives via Ruthenium (II)-Catalyzed Enantioselective C-H Functionalization
Overview of Technology Provides a cost-effective, easy preparation, versatile and distinct reactivity for customization of the 4-formyl indoline derivatives Background This novel technology allows for some customization of the RU(II)-catalyzed method during asymmetric synthesis. Using the 4-formylindoline derivative (compound based on the indole...
Published: 7/26/2024
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Inventor(s):
Xin Cui
,
Zhong-Yuan Li
,
Chaminda Lakmal Hetti Handi
Keywords(s):
Category(s):
Advanced Materials
,
Pharma
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