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Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance

Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival. Invention Summary: Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...

Published: 1/6/2025 | Inventor(s): Pingping Hou, Daiyong Deng

Keywords(s): Anti-cancer

Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Chip-integrated Nanolaminate Nano-optoelectrode Arrays for Interfacial Electrochemical Reaction Monitoring

THE CHALLENGE: In the field of electrochemistry, understanding the dynamics of interfacial reactions is crucial for advancements in areas such as electrocatalysis, biosensing, and energy conversion. Real-time monitoring of these reactions allows scientists to gain insights into mechanisms that drive these processes. Accurate and detailed analysis of...

Published: 12/17/2024 | Inventor(s): Yuming Zhao, Chuan Xiao, Wei Zhou

Keywords(s):

Category(s): Technology Classifications > Chemicals/Materials

Battery-Free Wireless Epidermal Sensor Networks for Continuous and High-Fidelity Systolic Blood Pressure Monitoring

This invention is a wireless, battery-free system of epidermal sensors designed for continuous and high fidelity monitoring of physiological signals, such as blood pressure. The system eliminates the need for batteries by using a smartphone to wirelessly deliver power to the sensors and collect biosignals. The sensors are designed to function seamlessly...

Published: 12/17/2024 | Inventor(s): Philipp Gutruf, Kevin Kasper, Selman Kurt, S. Y. John Ho

Keywords(s):

Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Engineering & Physical Sciences > Communications & Networking > Wireless, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Sensors & Controls

Enzymatic Reactions for Modifying and Labeling Extracellular Vesicles

Applies Enzymatic Glycan Engineering to Functionalize and Tag Extracellular Vesicles This method for modifying extracellular vesicles combines enzymatic glycan engineering with chemoselective functionalization to unlock applications such as targeted drug delivery. Extracellular vesicles are lipid bilayer-enclosed nanoparticles secreted by cells, acting...

Published: 12/2/2024 | Inventor(s): Zhongwu Guo, Mohit Jaiswal, Yong Zeng, Xin Zhou, Jiatong Guo

Keywords(s):

Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Diagnostics

Specialized storage technology for preserving axonal viability

A specialized calcium-free solution preserves peripheral nerve axons for up to nine days at low temperatures, enhancing nerve graft viability for effective repair of injuries using polyethylene glycol fusion, promoting rapid sensory and motor recovery. Background Peripheral nerve injuries (PNIs) often result in segmental-loss defects, leading to immediate...

Published: 10/21/2024 | Inventor(s): George Bittner, David Jackson, Alexa Olivarez, Liwen Zhou, Cathy Yang

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation

Nanodelivery systems for long-term controlled release of pharmaceuticals

This invention describes a nanodelivery system for controlled drug release using biocompatible materials. It features implantable or injectable devices with precise aperture control for zero-order kinetics, ensuring consistent therapeutic delivery over extended periods of time. Background Implantable drug delivery systems offer significant advantages...

Published: 10/11/2024 | Inventor(s): Paul Ho, Junjun Liu, Tengfei Jiang, Salomon Stavchansky

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Medical technology > Medical devices

Cu-Ni fuel cell catalysts for dehydrogenation of methylcyclohexane

Reference #: 1670 The University of South Carolina is offering licensing opportunities for Cu-Ni fuel cell catalysts for dehydrogenation of methylcyclohexane. Background: On-board storage of H2 in a safe format has limited the use of fuel cells in mobile transportation applications. Cylinders of compressed H2 will be difficult to implement due to...

Published: 9/26/2024 | Inventor(s): John Monnier, John Meynard Tengco, Haiying Zhou, Yanjiao Yi

Keywords(s):

Category(s): Engineering and Physical Sciences, Environmental and Sustainability, Advanced Materials

Optically gated field emission cathodes

VALUE PROPOSITION Electron beam-based devices are critical to applications such as particle accelerators, high-power electromagnetic sources ranging from microwave to X-rays, vacuum electronic devices, e-beam lithography, electron microscopy, space-vehicle neutralization and emerging vacuum nanodevices. They are key elements in telecommunication systems,...

Published: 9/12/2024 | Inventor(s): Peng Zhang, Lan Jin, Yang Zhou

Keywords(s):

Category(s): Electrical

Label-free Single-molecule Immunoassay Technique

Detection and quantification of low-abundance biomarkers is essential to early disease detection, monitoring and treatment. While many techniques, have been developed for measuring single molecules, all require signal amplification, via enzyme amplification, or fluorescence or gold nanoparticle probes, which come with their own unique drawbacks, including...

Published: 9/3/2024 | Inventor(s): Shaopeng Wang, Xiaoyan Zhou

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices

Improved Methods For Cryopreservation Of Cells, Tissues, And Organs

Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...

Published: 12/23/2024 | Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge

Keywords(s):

Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing

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