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ASC-Targeted Nanoparticles for Browning White Adipose Tissue and Combatting Obesity and Metabolic Diseases
Invention Description Obesity and related metabolic diseases are increasing in prevalence in the US and worldwide. They are difficult to treat with traditional therapies such as lifestyle intervention, pharmacotherapy, and various surgical procedures because of low compliance, low efficacy, high side effects and cost. One promising new approach focuses...
Published: 1/12/2026
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Inventor(s):
Shu Wang
,
Aysegul Kartal Acet
,
Fang Zhou
Keywords(s):
Category(s):
Biological Nanotechnology
,
Non-Cancer Therapeutics
,
Nucleic Acid/Peptide/Protein Therapies
,
Pharmaceuticals
Portable Assay for COVID-19 Diagnostic
A low-cost, rapid, and more accurate gel electrophoresis-based assay using DNA nanoswitches for detecting COVID-19 and other viruses. Background: Viral diagnostics are of prime importance for testing infection rates and for timely treatment, especially in the case of a pandemic such as the current COVID-19 outbreak caused by the SARS-CoV-2 corona...
Published: 10/24/2025
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Inventor(s):
Kenneth Halvorsen
,
Lifeng Zhou
Keywords(s):
DNA
,
RNA
,
Technologies
Category(s):
Campus > University at Albany
,
Technology Classifications > Diagnostics
Direct Carrier Fractional Frequency Synthesizer Using a DiCAD-Based Digital-To-Phase Modulator (Case No. 2025-9AA)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a low-noise, DiCAD-based fractional frequency synthesis system that enables fine frequency resolution and enhanced signal stability for millimeter-wave applications. Background: Millimeter-wave (mmW) communication and radar systems demand carrier frequency...
Published: 10/16/2025
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Inventor(s):
Mau-Chung Chang
,
Christopher Chen
,
Adrian Tang
,
Jia Zhou
Keywords(s):
5G
,
Automotive
,
Bandwidth (Signal Processing)
,
Communications Satellite
,
efficiency bandwidth products
,
electrically-mediated sensing
,
Extremely High Frequency
,
Frequency conversion
,
frequency modulation
,
high frequency electronics
,
high-frequency signals
,
high-speed communications
,
Imaging
,
millimeter-wave
,
Millimeterwave network
,
Quantum Computer
,
Radar
,
satellite imaging
,
Signal-To-Noise Ratio
,
Telecommunication
Category(s):
Electrical
,
Electrical > Signal Processing
,
Software & Algorithms > Communication & Networking
,
Electrical > Electronics & Semiconductors > Circuits
,
Software & Algorithms
Systems and Methods for Analyzing Genetic Data for Assessment of Gene Regulatory Activity in Disease Prediciton, Diagnosis and Treatment
Systems and Methods for Analyzing Genetic Data for Assessment of Gene Regulatory Activity in Disease Prediction, Diagnosis and Treatment Princeton Docket # 21-3806 Sequence is at the basis of how the genome and its variations shape chromatin organization, regulate gene expression, and impact traits and diseases. Epigenomic profiling efforts have...
Published: 9/29/2025
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Inventor(s):
Olga Troyanskaya
,
Kathleen Chen
,
Jian Zhou
Keywords(s):
Category(s):
Biotechnology/Pharmaceuticals
,
Medical Devices/Diagnostics
,
Computer Science and Information Technology
Predicting Genomic Variation Effects on Human Gene Transcription
De novo prediction of tissue-specific expression effect and disease risk for every mutation in a human genome - ExpectoPrinceton Docket # 18-3423Sequence-based models, with their scalability and usage of sequence dependencies, enable a new era of mutation analysis at unprecedented scale that can yield a new perspective on human variation in human diseases...
Published: 9/29/2025
|
Inventor(s):
Olga Troyanskaya
,
Jian Zhou
,
Chandra Theesfeld
Keywords(s):
Category(s):
Biotechnology/Pharmaceuticals
,
Computer Science and Information Technology
DeepSEA and Seqweaver: Deep learning frameworks for the identification of de novo disease-causing mutations in noncoding sequences
DeepSEA and Seqweaver: Deep learning frameworks for the identification of de novo disease-causing mutations in noncoding sequences Princeton Docket #s 18-3426, 18-3440 Researchers at Princeton University and Rockefeller University have collaborated to establish methods for the identification of de novo mutations in the vast noncoding genomic sequences....
Published: 9/29/2025
|
Inventor(s):
Jian Zhou
,
Olga Troyanskaya
,
Christopher Park
,
Robert Darnell
,
Chandra Theesfeld
Keywords(s):
Category(s):
Computer Science and Information Technology
Compounds that Disaggregate Alzheimer's Disease-Associated Fibrils of Tau Protein (UCLA Case No. 2022-145, 2025-329)
UCLA researchers in the Department of Biological Chemistry, Chemistry and Biochemistry developed a new tau-inhibiting seven residue peptide and conjugated it to magnetic nanoparticles for the treatment of Alzheimer’s disease. These compounds disaggregate pathogenic tau amyloid fibrils at atomic resolution, restore normal neuronal function, and...
Published: 11/19/2025
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Inventor(s):
David Eisenberg
,
Ke Hou
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
SPLICER: Small Molecule-Inducible Gene Expression Switches
Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...
Published: 1/20/2026
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Inventor(s):
Eric Wang
,
Yu Zhou
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
,
Technology Classifications > Research Tools > Therapeutics
One-Pot Wonder. Precision-Crafted Nanocrystals, The Power of Platinum Without the Price.
Title: One-Pot Wonder. Precision-Crafted Nanocrystals, The Power of Platinum Without the Price. This invention introduces a one-pot synthesis of Mn-based spinel nanocrystals with {101} facets, delivering high ORR efficiency and durability as a cost-effective, non-platinum catalyst for fuel cells. Background: Platinum-based catalysts dominate proton...
Published: 11/19/2025
|
Inventor(s):
Jiye Fang
,
Ming Zhou
Keywords(s):
Technologies
Category(s):
Campus > Binghamton University
,
Technology Classifications
,
Technology Classifications > Clean Energy
,
Technology Classifications > Energy
,
Technology Classifications > Materials and Chemicals
Beam-controlled Spectral-selective Architecture for a Radiative Cooler
This invention enhances radiative cooling of buildings by manipulating the divergent angle of thermal emission. By adjusting the direction at which heat is diverted away from buildings by this beam controlled design, the dependence of radiative cooling performance on the presence of surrounding architecture and environment can be minimized. US12352...
Published: 10/22/2025
|
Inventor(s):
Qiaoqiang Gan
,
Lyu Zhou
,
Zongfu Yu
,
Haomin Song
Keywords(s):
Category(s):
Technology Classifications > Energy Conservation
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