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Optically gated field emission cathodes
VALUE PROPOSITION Electron beam-based devices are critical to applications such as particle accelerators, high-power electromagnetic sources ranging from microwave to X-rays, vacuum electronic devices, e-beam lithography, electron microscopy, space-vehicle neutralization and emerging vacuum nanodevices. They are key elements in telecommunication systems,...
Published: 9/12/2024   |   Inventor(s): Peng Zhang, Lan Jin, Yang Zhou
Keywords(s):  
Category(s): Electrical
Label-free Single-molecule Immunoassay Technique
Detection and quantification of low-abundance biomarkers is essential to early disease detection, monitoring and treatment. While many techniques, have been developed for measuring single molecules, all require signal amplification, via enzyme amplification, or fluorescence or gold nanoparticle probes, which come with their own unique drawbacks, including...
Published: 9/3/2024   |   Inventor(s): Shaopeng Wang, Xiaoyan Zhou
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices
Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024   |   Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge
Keywords(s):  
Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat
MEDREX (Case No. 2024-244)
Summary: UCLA researchers have developed a new software package to reconcile medication lists between different electronic health records. Background: Reconciliation is a crucial process that ensures patients’ medication lists are accurate. This process is especially important for patients with memory impairments, who may be more vulnerable...
Published: 8/14/2024   |   Inventor(s): Li Zhou, Richard Korf, Cindy Liu, Edmond Wen, Advaith Gowrishetty, Jonathan Xu, Nicole Ju
Keywords(s): Software, Software & Algorithms, Software Development Tools, Software-enabled learning
Category(s): Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Programs, Software & Algorithms > Data Analytics
A Method and System for Pre-processing Medical Images (Case No. 2024-177)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel pre-processing computer algorithm for automated medical imaging. Background: The integration of machine learning and artificial intelligence into medical imaging applications offers significant potential to automate the diagnosis of various...
Published: 7/23/2024   |   Inventor(s): Bahram Jalali, Callen MacPhee, Yiming Zhou, Koichiro Kishima
Keywords(s): 3D ultrasound imaging, Artificial Intelligence, bioimaging, Computer Vision, histopathology images, Machine Learning, Medical Imaging, MRI, X-Ray
Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Immunology, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing
Anti-Galectin-1 Monoclonal Antibody
Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...
Published: 7/2/2024   |   Inventor(s): Douglas Lake, Kirsten Pfeffer, Thai Ho
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
One and done: A variant-proof coronavirus vaccine
Background/problem Coronaviruses, including SARS-CoV-2, caused the COVID-19 pandemic of plague-like infectiousness with >770 M cases and 6.9M deaths worldwide. Vaccination provided protection against severe disease progression, hospitalization, and mortality. However, current vaccine technology is in an arms race against the continual evolution...
Published: 6/21/2024   |   Inventor(s): Jason McLellan, Ling Zhou, Ching-Lin Hsieh, Rommie Amaro, Masaru Kanekiyo, Sila Ataca, Yaroslav Tsybovsky, Xandra Nuqui, Lorenzo Casalino, Mohamed Shehata
Keywords(s):  
Category(s): Life sciences > Therapeutics, Life sciences > Therapeutics > Vaccines
Tandem Antigen Capture ELISAs for Measuring Short and Long Isoforms of QSOX1
Quiescin sulfhydryl oxidase1 (QSOX1) is a sulfhydryl oxidase that is overexpressed in several malignancies and as such is a potential biomarker for multiple cancer types as well as acute decompensated heart failure (ADHF). Since its discovery, QSOX1 has been identified as a key player in the facilitation of tumor cell migration, creating a significant...
Published: 5/31/2024   |   Inventor(s): Douglas Lake, Thai Ho, Calvin Koelbel
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs)
YAP-TEAD Core Inhibitors for Developing Cancer Therapeutics
Inhibit YAP-TEAD Interactions for the Treatment of Diseases with Altered Hippo Signaling These small molecule inhibitors target TEA domain (TEAD) proteins, with the potential to treat diseases with altered Hippo signaling, such as Hepatocellular Carcinoma (HCC) and Hepatoblastoma (HB). The Hippo signaling pathway is vital to organ growth control, stem...
Published: 9/3/2024   |   Inventor(s): Chenglong Li, Chen Zhou, Liya Pi, Chunbao Sun
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Giant Second-Harmonic Generation in Bulk Monolayer MoS2 Thin Films (Case No. 2024-186)
Summary: UCLA researchers in the department of Chemistry and Biochemistry have developed a method to control electron density in molybdenum disulfide (MoS2) thin films that can be used to improve optical material characteristics. Background: Second harmonic generation (SHG) is an optical process in which light interacts with a nonlinear material...
Published: 7/3/2024   |   Inventor(s): Xiangfeng Duan, Yu Huang, Boxuan Zhou
Keywords(s): Adaptive Optics, Algorithm Optical Coherence Tomography, all-optical diffractive computing, all-optical transformation, Atomic Force Microscopy Optical Tweezers, bulk monolayer, Composite Material, Composite Materials, Dispersion (Optics), Electro-Optics, Focus (Optics), Functional Materials, Infrared Electromagnetic Spectrum Dispersion (Optics), linear optics, material characterization, Materials, molybdenum disulfide (MOS2), monolayer, Nanomaterials, Near-Field Scanning Optical Microscope, nonlinear dynamics, Nonlinear Optics, non-linear optics, Nonlinear Optics Molecular Dynamics, Optical Coherence , Optical Communication , Optical computing, optical implementation, Optical networks, optical processor, optical transmission, Optics Parabolic Reflector Curved Mirror, Optoelectronic materials, reverse engineered optical system, second harmonic generation, start to end optics design, Surgical Instrument Optical Coherence Tomography
Category(s): Materials, Materials > Functional Materials, Optics & Photonics, Chemical, Chemical > Instrumentation & Analysis
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