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Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles

An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...

Published: 9/10/2025 | Inventor(s): David Issadore, Zijian Yang

Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement

Glycosyltransferase Mutation-Activity Landscape

A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases Background: Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...

Published: 9/12/2025 | Inventor(s): Sriram Neelamegham, Ryoma Hombu

Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines

Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering

Blood Biomarker Diagnostic Kit for Cannabinoid Hyperemesis Syndrome (CHS)

Cannabinoid Hyperemesis Syndrome (CHS) is a condition that causes repeated, severe vomiting in some people who use cannabis regularly. It’s becoming more common, but doctors often struggle to diagnose it because its symptoms mimic other illnesses. Today, CHS is diagnosed by ruling out other causes—often leading to delays and unnecessary...

Published: 9/12/2025 | Inventor(s): Andrew Meltzer, Timothy McCaffrey

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Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Dx

Bioresorbable Cardiovascular Instruments and Methods

Implantable permanent pacemakers are essential for treating bradyarrhythmias and AV block, while temporary pacing systems support patients with short-term needs, such as post-surgical bradycardia or as a bridge to permanent therapy. Temporary pacing systems include an external generator with one or two transcutaneous pacing leads. This hardware, however,...

Published: 9/12/2025 | Inventor(s): Igor Efimov, Rose Yin, John Rogers, Yeonsik Choi

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Category(s): Technology Classifications, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices > Cardiology

Systems and Methods for Detecting Acute Changes in Blood Pressure and Creating Alarm, from Photoplethysmogram

Invention Summary: Recently, the data-driven capabilities of deep learning have been leveraged in blood pressure (BP) monitoring systems that utilize photoplethysmogram (PPG) signals. These advancements aim to enhance estimation accuracy, clinical applicability, and ultimately, patient outcomes. However, challenges persist—particularly...

Published: 8/12/2025 | Inventor(s): Laleh Najafizadeh, Weinan Wang

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Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright

High Quality, Differentiable, Imaging Method for Improving Computed Tomography (CT) Images

A method of CT imaging where the techniques of using non-circular orbits around the target and spectral imaging are combined resulting in fewer metal artifacts and higher image quality. Problem: Imaging techniques such as CT and Cone Beam Computed Tomography (CBCT) are highly susceptible to metal artifacts in interventional scenarios. Metal surgical...

Published: 8/1/2025 | Inventor(s): Jianan (Grace) Gang, Joseph Webster Stayman

Keywords(s): Neurology, Radiology, Software

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices

Robot-Aided System And Method For Diagnosis Of Autism Spectrum Disorder

Sensory abnormalities are reported to be central to autistic experience. The symptoms include hyposensitivity, hypersensitivity, multichannel receptivity, processing difficulties and sensory overload. Given the intensive and cumbersome nature of current methods of diagnosis, there is a need of behavior-based approach to identify the children at risk...

Published: 9/12/2025 | Inventor(s): Chung Hyuk Park, Hifza Javed

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices > Therapeutic Devices

Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics

This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications. Background: There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...

Published: 9/11/2025 | Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang

Keywords(s): Technologies

Method and Apparatus for Simultaneous Acquisition of Electrocardiogram Signals and Electrical Impedance Tomography Data

A new imaging technology that can be used with an electrocardiogram to aid the diagnosis and treatment of cardiac and pulmonary conditions. Background: Electrical impedance tomography (EIT) is a new imaging technology that can be used with an electrocardiogram (EKG) to aid the diagnosis and treatment of cardiac and pulmonary conditions. Examples...

Published: 5/13/2025 | Inventor(s): Gary Saulnier, Ahmed Abdelwahab, Omid Rajabi Shishvan, Nilton Barbosa da Rosa

Keywords(s): electrical impedance tomography, electrocardiogram, heart/lung function, medical equipment, medical imaging, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging

In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses

This technology provides a valuable tool for studying the molecular and cellular basis of dental plaque-mediated diseases. Background: In vitro oral microcosm communities, seeded with mixed communities of human dental plaque, have proven to be essential tools for studying the taxonomic composition of dental plaque communities and changes in community...

Published: 5/13/2025 | Inventor(s): Alex Valm

Keywords(s): biofilm control, dental, dental materials, structural biology, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Dental, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents

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