Search Results - technology+classifications+%3e+cancer

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Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance
​ Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival. Invention Summary: Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...
Published: 1/6/2025   |   Inventor(s): Pingping Hou, Daiyong Deng
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
PRISM: Precise Identification of Species of the Microbiome
​ Invention Summary: The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained...
Published: 12/17/2024   |   Inventor(s): Bassel Ghaddar, Subhajyoti De
Keywords(s):  
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
MYC Program as a biomarker of response to treatment with Enzalutamide
​ Invention Summary: Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 12/12/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Method for Treating Melanoma using an Inhibitor of an Atypical Protein Kinase C (PKC)
­Advantages: Effectively decreases melanoma cell proliferation and suppresses tumor migration and metastasis. Promotes cancer cell death, specifically targeting melanoma cells and sparing healthy melanocytes. The method not only treats melanoma by targeting atypical PKC isoforms but also utilizes PKC-ι and PKC-ζ levels as biomarkers...
Published: 8/16/2024   |   Inventor(s): Mildred Acevedo-Duncan, Wishrawana Ratnayake, David Ostrov
Keywords(s): Cancer Treatment Melanoma
Category(s): Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Therapeutics, Technology Classifications > Cancer
Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR for Cancer Treatment
­Advantages: Novel cyclic γ-AA peptide (M-2-5) effectively binds with EGFR and inhibits tumor growth in an A549 lung cancer xenograft model. M-2-5 interferes with EGFR-EGF binding, prevents EGFR phosphorylation, and suppresses cancer cell proliferation and migration. Targets the extracellular domain of EGFR with high affinity and specificity....
Published: 7/29/2024   |   Inventor(s): Jianfeng Cai, Mengmeng Zheng
Keywords(s):  
Category(s): Technology Classifications > Cancer
Bioinformatic Methods for Determining Resistance to Cancer Treatments
​ ​ Invention Summary: Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible. Researchers at Rutgers University have...
Published: 11/12/2024   |   Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
A novel inhibitory mimetic peptide slows down tumor development
​ ​ Inhibitory peptide increases caspase3 activity (A) by blocking GC1/Trx1 complex thereby limiting cell proliferation by inducing cell death (B). Invention Summary: Soluble guanylyl cyclase (GC1) and thioredoxin 1 (Trx1), when physically interacting and attaching to each other, they acquire the ability to induce changes in other target...
Published: 7/22/2024   |   Inventor(s): Annie Beuve
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan, Sloan Breedy, Aaron Todman, Luke Lajmi
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Mildred Acevedo-Duncan, Kirpal Bisht
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer, Technology Classifications > Medical > Pharmaceuticals
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer
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