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Method for Treating Melanoma using an Inhibitor of an Atypical Protein Kinase C (PKC)
­Advantages: Effectively decreases melanoma cell proliferation and suppresses tumor migration and metastasis. Promotes cancer cell death, specifically targeting melanoma cells and sparing healthy melanocytes. The method not only treats melanoma by targeting atypical PKC isoforms but also utilizes PKC-ι and PKC-ζ levels as biomarkers...
Published: 8/16/2024   |   Inventor(s): Mildred Acevedo-Duncan, Wishrawana Ratnayake, David Ostrov
Keywords(s): Cancer Treatment Melanoma
Category(s): Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Therapeutics, Technology Classifications > Cancer
Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR for Cancer Treatment
­Advantages: Novel cyclic γ-AA peptide (M-2-5) effectively binds with EGFR and inhibits tumor growth in an A549 lung cancer xenograft model. M-2-5 interferes with EGFR-EGF binding, prevents EGFR phosphorylation, and suppresses cancer cell proliferation and migration. Targets the extracellular domain of EGFR with high affinity and specificity....
Published: 7/29/2024   |   Inventor(s): Jianfeng Cai, Mengmeng Zheng
Keywords(s):  
Category(s): Technology Classifications > Cancer
Bioinformatic Methods for Determining Resistance to Cancer Treatments
​ ​ Invention Summary: Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible. Researchers at Rutgers University have...
Published: 7/15/2024   |   Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
A novel inhibitory mimetic peptide slows down tumor development
​ ​ Inhibitory peptide increases caspase3 activity (A) by blocking GC1/Trx1 complex thereby limiting cell proliferation by inducing cell death (B). Invention Summary: Soluble guanylyl cyclase (GC1) and thioredoxin 1 (Trx1), when physically interacting and attaching to each other, they acquire the ability to induce changes in other target...
Published: 7/22/2024   |   Inventor(s): Annie Beuve
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan, Sloan Breedy, Aaron Todman, Luke Lajmi
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Mildred Acevedo-Duncan, Kirpal Bisht
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer, Technology Classifications > Medical > Pharmaceuticals
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer
Off-the-Shelf CAR-Macrophages for Solid Tumors
​ ​ Invention Summary: Chimeric Antigen Receptor (CAR) therapy requires isolation of the respective immune cells from the patient’s blood, genetic manipulation, and infusion of the modified cells back into the patient’s body. This makes it personalized and effective but expensive. The CAR-T (modified T cells) therapy has shown...
Published: 1/11/2024   |   Inventor(s): Pingping Hou
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
Method for measuring Alu RNA
Advantages: Accurate Quantification: The competitive RT-PCR method allows for precise measurement of the ratio between fl-Alu and sc-Alu transcripts. Sensitivity: The assay can detect even low levels of Alu RNA expression. Versatility: The primer set used in the assay can amplify the most abundant form of Alu, making it applicable for various samples...
Published: 5/20/2024   |   Inventor(s): Hana Totary-Jain
Keywords(s): Autoimmune Diseases, Cancer, Genetics, Infectious Diseases, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology, Technology Classifications > Cancer
Novel Vascular Endothelial Growth Factor Mimetics as Inhibitors or Activators of Angiogenesis
Advantages: Novel helical VEGF mimicking peptides that can inhibit or activate angiogenesis. Mimetics hold promise as therapeutic agents for intervention in angiogenesis-related diseases. The sulfono-γ-AA peptides exhibit remarkable stability against proteolytic hydrolysis, ensuring their durability and effectiveness in biological systems. Summary: Angiogenesis,...
Published: 6/11/2024   |   Inventor(s): Jianfeng Cai, Sami Abdulkadir
Keywords(s): Cancer, Peptides, Therapeutics
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics
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