Search Results - technology+classifications+%3e+cancer

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Anti-sense Oligonucleotide Targets Insulin Receptor Isoform A
​ IR-A ASO targets the exon 10-12 junction in of IR-A mRNA. Invention Summary:  Breast cancer is one of the most common cancers among women, and while effective treatment options exist, there remains a critical need to enhance their efficacy and reduce their off-target effects to minimize toxicity. Expression of Insulin receptor-A (IR-A),...
Published: 4/8/2025   |   Inventor(s): Teresa Wood, Christopher Galifi
Keywords(s):  
Category(s): Technology Classifications > Cancer, Technology Classifications > Therapeutics
Multiphasic Localized in vivo Molecular Delivery
Advantages: Asymmetric biphasic pulses significantly reduced stimulation of skeletal muscle contractions in vivo and enhanced gene delivery Enables delivery of insulin and glucokinase to replace daily injections with long-term, non-immunogenic protein expression in skeletal muscle Higher-efficiency gene therapies avoid immunogenicity and off-target...
Published: 2/21/2025   |   Inventor(s): Anna Bulysheva, Mark Jaroszeski, Richard Heller
Keywords(s): Cancer Treatment, Drug Delivery Systems, Medical Therapeutics Gene Therapy, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Cancer, Technology Classifications > Medical > Biomedical Engineering
Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes
Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...
Published: 2/12/2025   |   Inventor(s): Timothy Yeatman, Mingli Yang
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry
Novel FISH probes for the prognosis of malignant transformation in Barrett’s epithelium
Left: Translocations as visualized by FISH assay during metaphase. Right: Fusion as visualized in human esophageal adenocarcinoma tissue section Invention Summary: Barrett’s epithelium (BE) is a premalignant tissue that can progress into esophageal adenocarcinoma (EA) following the metaplasia→low grade dysplasia→ high grade dysplasia→cancer...
Published: 4/10/2025   |   Inventor(s): Kiron Das, Manisha Bajpai, Hana Aviv
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
Application of a PS-Targeting Molecule Combined with Memory T cell Antigen for Therapeutic, Diagnostic, and Adjuvant Use
​ PS binding molecules could restore inactive or memory T cell functions. Invention Summary: Phosphatidylserine (PS) exposure on the cell surface is often a signal for phagocytosis and can lead to an immunosuppressive effect. Therefore, its inhibition by PS-binding biomolecules can promote a more immuno-responsive microenvironment. However,...
Published: 1/21/2025   |   Inventor(s): Alok Choudhary
Keywords(s): Antibacterial, Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
​ Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. Invention Summary: The Keap1-Nrf2-ARE system could protect...
Published: 1/14/2025   |   Inventor(s): Longqin Hu, Ahmed Ali
Keywords(s):  
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance
​ Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival. Invention Summary: Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...
Published: 1/6/2025   |   Inventor(s): Pingping Hou, Daiyong Deng
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
PRISM: Precise Identification of Species of the Microbiome
​ Invention Summary: The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained...
Published: 12/17/2024   |   Inventor(s): Bassel Ghaddar, Subhajyoti De
Keywords(s):  
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
MYC Program as a biomarker of response to treatment with Enzalutamide
​ Invention Summary: Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 12/12/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Method for Treating Melanoma using an Inhibitor of an Atypical Protein Kinase C (PKC)
­Advantages: Effectively decreases melanoma cell proliferation and suppresses tumor migration and metastasis. Promotes cancer cell death, specifically targeting melanoma cells and sparing healthy melanocytes. The method not only treats melanoma by targeting atypical PKC isoforms but also utilizes PKC-ι and PKC-ζ levels as biomarkers...
Published: 8/16/2024   |   Inventor(s): Mildred Acevedo-Duncan, Wishrawana Ratnayake, David Ostrov
Keywords(s): Cancer Treatment Melanoma
Category(s): Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Therapeutics, Technology Classifications > Cancer
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