Search Results - steven+hanes

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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Use and Administration of Ess1 Inhibitors to Treat Fungal Infections
A new class of antifungal drugs to treat resistant fungal infections. Background: Fungal Infections are a major cause of human disease. Annually, over 150 million severe cases of fungal infections occur worldwide, resulting in approximately 1.7 million deaths per year.The four classes of antifungal drugs to treat life-threatening infections have...
Published: 5/13/2025   |   Inventor(s): Steven Hanes, Stephen Parent, Charles Boone, Sheena Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering, Campus > Upstate Medical University
Novel Bronchodilators For Treating Obstructive Lung Disease
­Competitive Advantages Identified novel bronchodilators agonists that relax airway smooth muscle Could be a novel therapeutic for asthma and other obstructive lung diseases Could also be a therapeutic for other types of bronchoconstriction caused by smoke or anaphylaxis Summary Currently patients with obstructive airways diseases have...
Published: 2/19/2025   |   Inventor(s): Stephen Liggett, James Leahy, Donghwa Kim, Steven An
Keywords(s): Medical Therapeutics Cell Therapy, Respiratory Diseases, Respiratory Diseases Treatment, Therapeutics
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics