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CD206 Small Molecule Modulators, Their Use and Methods for Preparation
Abstract: Pancreatic ductal adenocarcinoma (PDA) accounts for more than 90% of pancreatic cancer cases, and it is one of the most aggressive malignancies with a 5-year survival rate of 6%. The high mortality rate caused by PDA is primarily from the lack of early diagnosis – it is often asymptomatic in early stages – and a poor response to conventional...
Published: 4/8/2024   |   Inventor(s): Udo Rudloff, Juan Marugan, Xin Hu, Raul Calvo, Noel Southall, Bolormaa Baljinnyam
Keywords(s): CD206, M1 Macrophage, M2 Macrophage, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, PDA, Rudloff, TAM, Tumor-Associated Macrophages
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration
A Modular Strategy for Distributed, Embodied Control of Electronics-Free Soft Robots
A kirigami-inspired robot made without hard electronic controls, with soft modular sensors for navigating diverse environments. Problem: Soft robots are promising new machines that can adapt and operate in diverse confined and dynamic environments. Such machines are promising for industrial manufacturing, exploratory, and medical applications. For...
Published: 2/7/2024   |   Inventor(s): Jordan Raney, Qiguang He, Rui Yin, Yucong Hua, Jiao Weijian, Chengyang Mo, Hang Shu
Keywords(s): Soft Materials
Category(s): Technology Classifications > Robotics
The Use of Emetine for the Treatment of SARS-CoV-2 Infection
This technology includes the clinical use of the small compound emetine for the treatment of SARS-CoV-2. Previous work has shown that emetine has antiviral properties against some DNA and RNA viruses. It is thought that the mechanism may involve blocking protein synthesis. Work has shown that emetine has potential antiviral activity in multiple tissues...
Published: 10/28/2024   |   Inventor(s): Mark Henderson, Juan Marugan, Andreas Dulcey Garcia, Xin Hu, Marc Ferrer-Alegre, Noel Southall
Keywords(s): Emetine, Infection, SARS-CoV-2, treatment, VLXXXX, WIXXXX, WKXXXX
Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Research Materials
Creation of a High-density Screening Format and the Identification of Small Molecule Inhibitors of the SIX/EYA Interaction for the Treatment of Cancers
The technology includes the creation of a high-throughput assay and the identification and use of small molecules that inhibit the SIX/EYA interaction as a treatment for cancer. The Eya proteins are phosphatases that form a complex and are activated by the Six family of homeobox transcription factors. The interaction of Eya and Six mediates breast cancer...
Published: 10/28/2024   |   Inventor(s): Marc Ferrer-Alegre, Xin Hu, Juan Marugan, Lesley Mathews, Heide Ford, Melanie Blevins, Rebecca Mull, Rui Zhao
Keywords(s): cancers, Identification, Identifying, Inhibitors, INTERACTION, Listed LPM Vathyam as of 4/15/2015, Method, MOLECULE, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SIX/EYA, Small, treatment, VCXXXX, WIXXXX, WKXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology
Identification and Use of a Novel Functionally Selective GHSR1a Ghrelin Receptor Inhibitor, including NCGC00538279, for the Treatment of Food and Chemical Addiction
This technology includes a chemical series, including the NCGC00538279 compound, that selectively activates the GHSR1a G-protein pathway for calcium mobilization while only partially activating the beta-arrestin-2 translocation pathway. The resulting chemical series may be therapeutically valuable for addictive disorders. Activation of the GHSR1a G-protein...
Published: 10/28/2024   |   Inventor(s): Noel Southall, Marc Ferrer-Alegre, Daniel Jansen, Mark Henderson, Xin Hu, David Kim, Juan Marugan
Keywords(s): ADDICTION, Chemical, FOOD, Funtionally, Ghrelin, LIGAND, NCG00538279, Novel, RECEPTOR, SELECTIVE, treatment, VEXXXX, VGXXXX, WIXXXX, WKXXXX, XEXXXX
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Endocrinology, Application > Research Materials
Heterocyclic Compounds for the Treatment of Hepatitis C Virus
The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that have changed the HCV treatment paradigm. However, the...
Published: 10/28/2024   |   Inventor(s): Zongyi Hu, Juan Marugan, Noel Southall, Xin Hu, Jingbo Xiao, Shanshan (Melissa) He, Marc Ferrer-Alegre, Wei Zheng, Kevin Frankowski, Frank Schoenen, Kelin Li, Tsanyang (Jake) Liang
Keywords(s): C, Class, compounds, DB4BXX, Development, Hepatitis, Novel, treatment, VLXXXX, WKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023   |   Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Systems and Methods of Using Phase Change Material in Power Plants
PAGE TITLEOverviewPAGE SUMMARY Cooling systems and methods for cooling in a power plant using a phase change material. In one embodiment, a phase change material container includes at least one phase change material which may be in the form of a slurry; and at least one conduit for transporting the fluid through the phase change material when located...
Published: 7/24/2024   |   Inventor(s): Matthew Mccarthy, Ying Sun, Young Cho, Baolan (jessica) Shi, Han Hu, Philipp Boettcher, Qinghua (tim) Xie
Keywords(s):  
Category(s): Energy, Mechanical & Civil Engineering, Energy > Energy: Heat Exchangers, Energy > Energy: Power Plants, Mechanical & Civil Engineering > ME-CE: HVAC
Novel Inhibitors of GAB1
The compounds discovered in this patented technology could be used as a breast cancer therapeutic drug. There are a few call signaling pathways that are heavily involved in the pathogenesis of cancer. Two of these pathways are the RAS pathway and the PI3K pathway, and both of these pathways are deregulated in the formation of human cancer. This...
Published: 4/3/2023   |   Inventor(s): Emmanuelle Meuillet, Lu Chen, Shuxing Zhang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules
Targeting the PH/DH Domain of Tiam1 for the Treatment and/or Prevention of Bone Metastases
Tiam1 is a highly conserved exchange factor that is over-expressed in many cancers, including prostate cancer (CRPCA). Increase in Tiam1 expression is associated with increased metastases and correlates with poor PCA patient survival prognosis. This patented technology has identified a novel compound which exhibits the ability to reduce prostate cancer...
Published: 4/3/2023   |   Inventor(s): Emmanuelle Meuillet, Sylvestor Moses, Shuxing Zhang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
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