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Search Results - shanshan+(melissa)+he
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TRP: A Mouse Model of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA researchers in the Department of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
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Inventor(s):
Melissa Spencer
Keywords(s):
Category(s):
Life Science Research Tools > Animal Models
Nutrition Screening Algorithm for Cleft Repair
Invention Summary: Cleft lip and palate are common craniofacial birth defects affecting approximately one in 700 live births. Early intervention via surgical repair can improve appearance, speech, hearing, and psychosocial development. Models for fast identification and surgical intervention for affected infants and children, including models...
Published: 7/28/2025
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Inventor(s):
Melissa Wallinga
,
Laura Byham-Gray
,
Jane Ziegler
,
Alainn Bailey
Keywords(s):
Category(s):
Technology Classifications > Education
,
Technology Classifications > Software & Copyright
Novel AAV Serotypes Derived From a Library Screen (UCLA Case No. 2020-789)
UCLA researchers in the Department of Neurology have produced novel AAV serotypes for a wide range of tissue and cell specific gene delivery. BACKGROUND: Gene therapies are the forefront of therapeutic advancements for debilitating diseases. However, delivery and insertion of the therapeutic transgene are major hurdles that must be solved to effectively...
Published: 7/17/2025
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Inventor(s):
Melissa Spencer
Keywords(s):
Category(s):
Therapeutics > Gene Therapy And Editing
Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 5/13/2025
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Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
Technologies
Category(s):
Technology Classifications > Screens and Assays
,
Technology Classifications > Research Tools and Reagents
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Campus
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Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 5/13/2025
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Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 5/13/2025
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Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
ALS
,
amyotrophic lateral sclerosis
,
aptamers
,
drug design
,
Lou Gehrig's disease
,
MND
,
motor neurone disease
,
RNA
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus > University at Albany
Bouquet Fiber-based Neural Probe
THE CHALLENGE Neural probes are the key to unlocking the brain’s mysteries, yet current designs remain woefully inadequate. Most cutting-edge probes rely on outdated tip-based interactions, offering only a narrow, fragmented view of neural activity while leaving vast brain regions unexplored. Bulky, rigid structures provoke inflammation and...
Published: 6/30/2025
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Inventor(s):
Xiaoting Jia
,
Shan Jiang
Keywords(s):
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Electronics
,
Technology Classifications > Biotechnology
,
Technology Classifications > Biomedical
Method for Vascular Regeneration and Wound Treatment
Asset/Technology Type Therapeutic Strategy Description of Invention The invention is a therapeutic approach for modulating cellular trans-differentiation and potentially angiogenesis by modulating O-glcnacylation (GlcNAc) of proteins, to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo....
Published: 5/21/2025
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Inventor(s):
John Cooke
,
Li Lai
Keywords(s):
Category(s):
Clinical Area
,
Clinical Area > Cardiovascular
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Research Area > Heart and Vascular
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Research Area > Regenerative Medicine
,
Technology Classifications
,
Technology Classifications > Other
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025
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Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Veterinary > Diagnostics
Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications
Reference #: 1742 The University of South Carolina is offering licensing opportunities for Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications. Background: Fluorophores have been used in various applications of cellular microbiology, most notably with the reporting functions associated with various biological...
Published: 6/30/2025
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Inventor(s):
Qian Wang
,
Shan Hu
Keywords(s):
Category(s):
Chemistry and Biochemistry
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