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Search Results - shanshan+(melissa)+he
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Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
Technologies
Category(s):
Technology Classifications > Screens and Assays
,
Technology Classifications > Research Tools and Reagents
,
Campus
,
Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
ALS
,
amyotrophic lateral sclerosis
,
aptamers
,
drug design
,
Lou Gehrig's disease
,
MND
,
motor neurone disease
,
RNA
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus > University at Albany
Bouquet Fiber-based Neural Probe
THE PROBLEM Neural probes are the key to unlocking the brain’s mysteries, yet current designs remain woefully inadequate. Most cutting-edge probes rely on outdated tip-based interactions, offering only a narrow, fragmented view of neural activity while leaving vast brain regions unexplored. Bulky, rigid structures provoke inflammation and tissue...
Published: 4/10/2025
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Inventor(s):
Xiaoting Jia
,
Shan Jiang
Keywords(s):
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Electronics
,
Technology Classifications > Biotechnology
,
Technology Classifications > Biomedical
Method for Vascular Regeneration and Wound Treatment
Asset/Technology Type Therapeutic Strategy Description of Invention The invention is a therapeutic approach for modulating cellular trans-differentiation and potentially angiogenesis by modulating O-glcnacylation (GlcNAc) of proteins, to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo....
Published: 5/21/2025
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Inventor(s):
John Cooke
,
Li Lai
Keywords(s):
Category(s):
Clinical Area
,
Clinical Area > Cardiovascular
,
Research Area > Heart and Vascular
,
Research Area > Regenerative Medicine
,
Technology Classifications
,
Technology Classifications > Other
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025
|
Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Veterinary > Diagnostics
Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications
Reference #: 1742 The University of South Carolina is offering licensing opportunities for Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications. Background: Fluorophores have been used in various applications of cellular microbiology, most notably with the reporting functions associated with various biological...
Published: 1/13/2025
|
Inventor(s):
Qian Wang
,
Shan Hu
Keywords(s):
Category(s):
Chemistry and Biochemistry
Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations
The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...
Published: 12/9/2024
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Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Planner – Planning Software for Near-Earth Object Survey Operations
The Planner subsystem in the Catalina Sky Survey (CSS) software suite is designed to help observers efficiently plan nightly asteroid and Near-Earth Object (NEO) observations. By displaying a virtual map of the sky, it helps ensure that areas previously searched, or areas unlikely to be productive, are avoided. The map shows the telescope’s current...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Processing – Software to Process and Analyze Images for NEO Survey
The Processing subsystem in the Catalina Sky Survey (CSS) software suite is a streamlined pipeline designed to handle raw images captured by telescopes during asteroid and Near-Earth Object (NEO) surveys. This pipeline processes the images through multiple stages, such as calibrating for optical distortions, extracting star or asteroid positions, and...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
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