Search Results - michael+cohen

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Compositions for treatment of neurological and oxidative stress disorders
Summary Dysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 10/3/2022   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
Small molecules promoting nerve regeneration
Summary Nerve regeneration is critical after an injury for proper healing and restoration of function, but many tissues, such as the heart and spinal cord, lack this capacity due to extensive scarring resulting in more permanent injury and loss of function. Researchers at Oregon Health & Science have discovered novel compounds that promote nerve...
Published: 9/21/2023   |   Inventor(s): Michael Cohen, Beth Habecker, Haihong Jin, Ryan Gardner, Matthew Blake
Keywords(s): Therapeutics - Cardiology, Therapeutics - Neurology
Category(s): Therapeutics
Clickable, photoactivatable NAD+ analogues as probes for PARP and other NAD+-binding targets
Summary Researchers at OHSU have developed a screening platform for identification of proteins regulated by PARPs, which relies on a novel bi-functional NAD analog containing a photo-reactive group for crosslinking to binding targets and a click tag for their identification. This tool can be used to efficiently screen cell lysates to uncover novel...
Published: 9/21/2023   |   Inventor(s): Sunil Sundalam, Michael Cohen
Keywords(s): Research Tools, Therapeutics, Therapeutics - Cancer, Therapeutics - Immunology, Therapeutics - Infectious Diseases
Category(s): Chemical, Research Tools, Therapeutics
Novel Heart Attack Therapy: Caspase Inhibition Prior to Repurfusion
OPPORTUNITY Preventing heart muscle death (infarction) during a heart attack is an important goal of treatment. To this end, patients typically receive platelet inhibitors and early opening of the thrombosed artery (reperfusion), both of which aim to reduce heart muscle loss. This treatment has lowered, but not eliminated, mortality and morbidity in...
Published: 12/4/2018   |   Inventor(s): Jonathon Audia, James Downey, Diego Alvarez, Michael Cohen
Keywords(s):  
Category(s): Therapeutics, All Technologies
Method for identifying Family-Member Specific Targets of Mono-PARPs
Summary Technology developed at OHSU provides a novel method to identify proteins regulated by PARP mono-ADP-ribosylation (MARylation), a post-translational modification carried out by the majority of enzymes within this family. This tool has the ability to link such PARPs to specific targets and broader biological pathways, thereby increasing our understanding...
Published: 9/29/2022   |   Inventor(s): Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
Keywords(s): Diagnostics - Platforms, Research Tools
Category(s): Diagnostics, Proteomics, Research Tools
Novel biosensor for direct measurement of bioavailable NAD+
Summary This technology provides a unique cell-based platform for targeting NAD+-(nicotinamide adenine dinucleotide) regulatory pathways in the treatment of human diseases. An emerging theme in age-related pathologies—e.g. neurodegeneration, cancer, cardiovascular disease, inflammation, type 2 diabetes, and metabolic disease—is due to the...
Published: 9/23/2022   |   Inventor(s): Richard Goodman, Michael Cohen, Xiaolu (Lulu) Cambronne, Melissa Stewart
Keywords(s): Research Tools - Screening
Category(s): Research Tools