Search Results - aaron+nilsen

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Malaria transmission blocking using ELQ-infused bed nets
Summary Insecticide-treated mosquito bed nets reduce the transmission of malaria, but mosquitos have developed resistance to insecticides leading to reduced efficacy. Our new technology is a chemical solution for mosquito nets that kills malaria, is less prone to drug-resistance and is not toxic to humans. Technology Overview Insecticide-treated...
Published: 10/15/2024   |   Inventor(s): Michael Riscoe, Aaron Nilsen, Joseph (Stone) Doggett, Flaminia Catteruccia, Douglas (Doug) Paton
Keywords(s): Therapeutics, Therapeutics - Infectious Diseases, Therapeutics - Other
Category(s): Therapeutics, Device, Chemical
Compounds Having Anti-Parasitic or Anti-Infective Activity
Competitive Advantages Effective on liver and blood stages of malaria Effective against drug-resistant strains of Plasmodium parasites Summary Chloroquine replacement drugs are urgently needed to treat and prevent malaria. The endoperoxides, like artemisinin are being used in other parts of the world for malaria therapy. However, the...
Published: 8/27/2023   |   Inventor(s): Aaron Nilsen, David Hinrichs, Dennis Kyle, Jane Kelly, Jeremy Burrows, Martin Smilkstein, Michael Riscoe, Richard Cross, Rolf Winter, Roman Manetsch
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals
Compositions for treatment of neurological and oxidative stress disorders
Summary Dysfunction of the mitochondrial permeability transition pore (mtPTP) is associated with accumulation of reactive oxygen species (ROS) in many disease states. Researchers at Oregon Health & Science University, University of Kansas, and University of Padova have developed highly potent and stable small molecule inhibitors of mtPTP. Technology...
Published: 10/3/2022   |   Inventor(s): Michael Cohen, Michael Forte, Justina Sileikyte, Jordan Devereaux, Aaron Nilsen, Paolo Bernardi
Keywords(s): Therapeutics, Therapeutics - Neurology, Therapeutics - Other
Category(s): Therapeutics
Cloroquine replacement drugs
Summary Researchers at Oregon Health & Science University and at the Portland VA Medical Center have discovered and optimized a novel class of antimalarial compounds that are superior to the standard of care. Technology Overview Malaria remains one of the deadliest diseases in the world today, as it has been for thousands of years. For each of...
Published: 9/22/2022   |   Inventor(s): Michael Riscoe, Rolf Winter, Sovitj Pou, David Hinrichs, Jane Kelly, Yuexin Li, Aaron Nilsen
Keywords(s): Therapeutics, Therapeutics - Infectious Diseases
Category(s): Therapeutics, Chemical