Search Results - life+sciences+%3e+therapeutics+%3e+drug+delivery

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Nasal-based rapid testosterone delivery system
A nasal spray formulation delivers testosterone or its derivatives quickly into the bloodstream via the nasal route, using water, medium-chain triglycerides, and a PEGylated surfactant. This method efficiently treats hypogonadism, low libido, and anxiety disorders . Background Testosterone is a crucial hormone in the human body, playing a significant...
Published: 9/13/2024   |   Inventor(s): Robert Josephs, Craig Herman
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Small molecule
Engineered polypeptides for enhanced integrin binding and antigen delivery
Engineered recombinant Invasin polypeptides have been modified to enhance integrin binding and resist intestinal proteolysis, facilitating effective oral delivery of therapeutics, such as vaccines, by targeting M cells in the gut for improved immune responses. Background The challenge of delivering therapeutics such as vaccines effectively across...
Published: 9/13/2024   |   Inventor(s): Jennifer Maynard, Xianzhe Wang, Tarik Khan
Keywords(s):  
Category(s): Life sciences > Therapeutics > Vaccines, Life sciences > Agriculture > Animal/veterinary, Life sciences > Therapeutics > Drug delivery
Enzyme delivery for lung injuries and infections using nebulized solutions and perfluorocarbons
The technology describes methods and compositions for treating lung injuries and infections by delivering enzymes, such as plasminogen activators, to the airway using nebulized solutions and perfluorocarbon carriers. This approach dissolves airway obstructions and supports respiratory function. Background Acute lung injury (ALI) and its severe form,...
Published: 9/9/2024   |   Inventor(s): Robert Williams, Steven Idell
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Biomimetic polymer networks for selective binding and controlled delivery of therapeutic agents
Biomimetic polymer networks are specialized materials with molecular imprints that selectively bind specific molecules, enabling controlled loading and delivery of therapeutic agents, such as glucose, through tailored noncovalent interactions within a crosslinked polymer matrix. Background Achieving selective molecular recognition in synthetic materials...
Published: 8/19/2024   |   Inventor(s): Nicholas Peppas, Mark Byrne, James Hilt
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Polymeric network technology for controlled delivery of active agents
The technology involves a polymeric network designed for controlled delivery of active agents, triggered by the binding of specific molecules. This interaction reduces the structural integrity of the polymer at designated micro- or nanovacuoles, causing it to rupture and release the agents. Background Controlled delivery of active agents within polymeric...
Published: 8/19/2024   |   Inventor(s): Nicholas Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
“Bio-Flex”: advanced formulation for sustainable stereolithography (SLA)
Background/problem Stereolithography (SLA) 3D printing has transformed the biomedical field with creation of highly accurate, patient-specific medical devices such as tissue scaffolds, implants, and surgical tools. This technology leverages computer-aided design and medical imaging data to produce structures with precise geometries at submicron scales....
Published: 7/26/2024   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Anqi Lu
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Therapeutics > Drug delivery
RECAST as an enhanced gene delivery system
Background/problem Gene therapy, a promising tool to explore pathogenesis and a powerful weapon to treat diseases at the genomic level, has been making strides in recent years. It has found use in various applications, from cell therapeutics to treating inherited, and neurodegenerative diseases. However, the current methods of gene (“therapy”,...
Published: 7/25/2024   |   Inventor(s): Huiliang Wang, Wenliang Wang, Aaron Tasset
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Processes and compositions to expand drug processing
Background Dr. Robert O. Williams III and his team have developed a method to expand the ability of the hot-melt extrusion process to increase drug loading in amorphous solid dispersions (ASD). Dr. Williams is the Division Head and Professor of Molecular Pharmaceutics and Drug Delivery and the Johnson & Johnson Centennial Chair in Pharmacy at UT...
Published: 8/27/2024   |   Inventor(s): Robert Williams, Daniel Davis, Stephen Thompson
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Reagent
Ultrasound-programmable nanoparticles for targeted drug release
Background/problem Ideally, a drug meant to accurately target specific tissues or cells involved in a disease will do so and achieve an optimal dose and treatment duration. These will yield the intended cellular and physiological response without undue off-target and side effects. And yet, we live with the reality and risks of side effects. Novel...
Published: 8/15/2024   |   Inventor(s): Wenliang Wang, Huiliang Wang, Yanshu Shi, Banglin Chen
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Biomaterials
Future drug-delivery system to treat brain tumors
Background/problem Glioblastoma (GBM) is the most common malignant, primary brain tumor observed in adults, occurring at an incidence rate of 3.19 per 100,000 persons in the United States in 2017. Even with complete surgical resection of the tumor and adjuvant chemotherapy, these tumors often reoccur, resulting in a median survival of ~15 months. Part...
Published: 6/6/2024   |   Inventor(s): Benjamin Umlauf, Bryan Davies, Austin Shipley, Gabriel Frampton
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery
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