Search Results - life+sciences+%3e+therapeutics+%3e+drug+delivery

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Thin-film freeze-dried antibiotic powders for fixed-dose pulmonary delivery
Background Pulmonary diseases such as nontuberculous mycobacterial infections and chronic obstructive pulmonary disease (COPD) remain major global health challenges, often requiring long-term antibiotic therapy delivered directly to the lungs to achieve effective pathogen clearance. Inhaled drug delivery provides a promising approach to increase local...
Published: 1/30/2026   |   Inventor(s): Zhengrong Cui, Reem Zaki, Michael Sandoval, Robert Williams, Jay Peters
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Thin film freezing technology for stable dry formulations of mRNA therapeutics
A thin film freezing method transforms mRNA and lipid nanoparticles into stable dry powders that retain their effectiveness and size. This eliminates the need for ultra-cold storage, allowing the powders to be inhaled or reconstituted, improving the distribution of mRNA therapies. Background mRNA therapeutics represent a groundbreaking advancement...
Published: 1/13/2026   |   Inventor(s): Robert Williams, Chaeho Moon, Sawittree Sahakijpijarn, Haiyue Xu, Zhengrong Cui
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Drug delivery
Additive manufacturing platform for customizable drug-releasing IUDs and pharmaceuticals
Using 3D printing to create customizable IUDs that can release multiple drugs in a controlled way, tailored to individual patient needs Background Intrauterine devices (IUDs) are a widely used form of long-acting reversible contraception, valued for their efficacy, low maintenance, and extended duration of action. The field of reproductive healthcare...
Published: 1/13/2026   |   Inventor(s): Mohammed Maniruzzaman, Leela Chakka, Yu Zhang, Gustavo Doncel, Vivek Agrahari, M. Peet
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery
Beta-sitosterol lipid nanoparticles for aerosolized gene editing in lung diseases
Background Cystic fibrosis (CF) is a life-threatening genetic disorder caused by mutations in the CFTR gene, leading to progressive lung dysfunction. A particularly challenging mutation, W1282X, introduces a premature stop codon that results in non-functional CFTR protein. Patients with this mutation are largely unresponsive to current small molecule...
Published: 1/13/2026   |   Inventor(s): Debadyuti Ghosh, Mae Lewis
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene editing, Life sciences > Therapeutics > Drug delivery
Engineered bacterial platform for in situ mRNA delivery to mammalian cells
Background Genetic medicine depends on the ability to deliver messenger RNA (mRNA) into mammalian cells to enable therapeutic protein expression, correct genetic defects, or produce antigens for vaccines. But current delivery systems face critical barriers that limit their clinical utility. DNA plasmid-based approaches often show poor transfection...
Published: 1/13/2026   |   Inventor(s): Bryan Davies, Christopher Sullivan, Andrew Ellington
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
Engineered microbial antigen-presenting system for targeted T cell activation
Background Targeted immunotherapy depends on the ability to modulate specific T cell populations to fight chronic infections, cancers, and autoimmune diseases. Achieving precise control over T cell activation is essential for generating effective immune responses while minimizing off-target effects. Traditional vaccines and existing antigen-presenting...
Published: 1/13/2026   |   Inventor(s): Bryan Davies, Rita Ousterhout
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
Dual-action topical formulations for enhanced skin penetration and targeted dermal repair
Background Dermatological and cosmetic treatments increasingly focus on targeted delivery of active compounds to the deeper skin layers to combat photoaging, oxidative damage, and carcino­genesis. However, the stratum corneum presents a formidable barrier to percutaneous absorption, limiting the efficacy of topically applied actives. Conventional...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Patricia Martins
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
High-dose dry powder inhaler for dual pulmonary and oral indomethacin delivery
Background Dry powder inhalers (DPIs) offer a non-invasive and rapid route for drug delivery, particularly for medications requiring swift systemic action. This is especially relevant for poorly soluble drugs such as indomethacin, where oral admini­stration is often limited by gastrointestinal degradation and adverse side effects. For indications...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Jamie Spahn, Feng Zhang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Multilayered drug delivery implants for localized brain tumor therapy
Background As treatment strategies evolve for brain tumors, especially post-surgical resection, localized therapy is emerging as a promising alternative to systemic drug delivery. The blood-brain barrier, along with the sensitive anatomy of the brain, makes it difficult to achieve effective therapeutic concentrations using traditional methods without...
Published: 1/13/2026   |   Inventor(s): James McGinity, Feng Zhang, John Floyd, Michael McGinity
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Covalent ERK inhibitors for suppressing cancer
BI-78D3, a small molecule, covalently binds to ERK1/2’s D-recruitment site, disrupting ERK signaling crucial for cancer cell growth. This shows promise for treating ERK-dependent cancers, including those resistant to BRAF inhibitors. This disrupts ERK signaling crucial for cell proliferation and survival, particularly in certain cancers like...
Published: 1/13/2026   |   Inventor(s): Kevin Dalby, Ramakrishna Edupuganti, Tamer Kaoud, Chelsea Massaro
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics
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