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Search Results - hairui+zhang
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Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids
Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization. Background Gene therapy and editing hold significant promise for treating genetic...
Published: 10/15/2024
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Inventor(s):
Hugh Smyth
,
Hairui Zhang
,
Robert Williams
Keywords(s):
Category(s):
Life sciences > Therapeutics > Formulation
,
Life sciences > Therapeutics > Drug delivery
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
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Inventor(s):
Leilei Peng
,
Yu Li
,
Han Zhang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
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Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Rapid Method to Design and Screen Novel Lipid Nanoparticles for mRNA Delivery In Vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo. Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant...
Published: 1/23/2024
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Inventor(s):
Michael Mitchell
,
Rui Zhang
,
Roman Spektor
Keywords(s):
Bioengineering
,
COVID-19
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Research Tools & Reagents
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Technology Classifications > Therapeutics