Search Results - nicholas+peppas

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pH-sensitive hydrogel technology for enhanced oral delivery of high molecular weight therapeutic proteins
This invention describes a pH-sensitive hydrogel for oral delivery of therapeutic proteins like factor VIII or IX, used in hemophilia treatment. It protects proteins in the stomach and releases them in the intestine, enhancing bioavailability. Background Delivering therapeutic proteins orally presents significant challenges due to the body's natural...
Published: 10/3/2024   |   Inventor(s): Nicholas Peppas, Sarena Horava
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
pH-responsive hydrogel technology for enhanced oral delivery of therapeutic proteins
Improved hydrogel copolymers, made from itaconic acid and N-vinyl­pyrrolidone, enable oral delivery of therapeutic proteins by protecting them in the stomach and releasing them in the intestine. This enhances protein bioavailability and pharmacokinetics. Background Oral delivery of therapeutic proteins presents significant challenges due to the...
Published: 10/3/2024   |   Inventor(s): Nicholas Peppas, Michael Koetting
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Synthetic biology
Molecularly imprinted polymers for high-specificity template molecule recognition
Molecularly imprinted polymers are created using calcium alginate microcapsules that can specifically recognize and bind template molecules like proteins. These biocompatible microcapsules are useful in medical diagnostics and food industry detection and can be reused after washing. Background Molecularly imprinted polymers (MIPs) have garnered significant...
Published: 9/27/2024   |   Inventor(s): Nicholas Peppas, Edgar Perez-Herrero
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
Highly porous recognitive polymer systems for controlled release of active agents
The invention is a porous, recognitive polymeric hydrogel system that releases active agents, like insulin, in response to specific triggers such as glucose. It uses methacrylic acid and sodium chloride to create a matrix that swells, cracks, or dissolves under low water or humidity conditions. Background The challenge of delivering active agents...
Published: 9/27/2024   |   Inventor(s): Nicholas Peppas, Aditya Durgam
Keywords(s):  
Category(s): Life sciences > Biomaterials
Polymeric tablet technology for controlled release of active agents
The invention describes a multi-layered polymer tablet designed for controlled release of active agents like pharma­ceuticals. Each layer contains specific polymers that respond to environmental triggers such as osmosis, solubility changes, or temperature variations to release the active agents in a controlled manner. Background The challenge...
Published: 9/27/2024   |   Inventor(s): Nicholas Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Recognitive biodegradable nanoparticles for targeted in vivo diagnostics and therapeutics
Recognitive biodegradable nanoparticles combine molecularly imprinted polymers with biodegradable cores to detect specific target molecules like proteins for in vivo diagnostics. They offer high affinity, selectivity, lower production costs, and reduced immunologic response. Background The field of molecularly imprinted polymers (MIPs) involves creating...
Published: 9/9/2024   |   Inventor(s): Nicholas Peppas, Heidi Culver
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Nanoscale, pH-responsive polycationic networks for targeted delivery of anionic biologic therapeutics
­This technology involves nanoscale, pH-responsive polycationic hydrogels for delivering anionic biologic therapeutics like siRNA. These hydrogels, made from crosslinked copolymers, trap therapeutics at physiological pH and release them in lower pH environments, enhancing biocompatibility and targeted delivery. Background The delivery of small...
Published: 9/6/2024   |   Inventor(s): Nicholas Peppas, William Liechty
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Biomaterials
Biomimetic polymer networks for selective binding and controlled delivery of therapeutic agents
Biomimetic polymer networks are specialized materials with molecular imprints that selectively bind specific molecules, enabling controlled loading and delivery of therapeutic agents, such as glucose, through tailored noncovalent interactions within a crosslinked polymer matrix. Background Achieving selective molecular recognition in synthetic materials...
Published: 8/19/2024   |   Inventor(s): Nicholas Peppas, Mark Byrne, James Hilt
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Polymeric network technology for controlled delivery of active agents
The technology involves a polymeric network designed for controlled delivery of active agents, triggered by the binding of specific molecules. This interaction reduces the structural integrity of the polymer at designated micro- or nanovacuoles, causing it to rupture and release the agents. Background Controlled delivery of active agents within polymeric...
Published: 8/19/2024   |   Inventor(s): Nicholas Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Resting-State Functional Magnetic Resonance Imaging Derived From Dynamic Perfusion Imaging (Case No. 2023-126)
Intro Sentence: UCLA researchers in the Department of Radiology have developed a novel method for obtaining simultaneous perfusion and functional MRI data from a single MRI acquisition to improve the diagnosis, monitoring, and management of brain tumors and stroke. Background: Advanced magnetic resonance imaging (MRI) techniques are crucial for...
Published: 10/23/2024   |   Inventor(s): Benjamin Ellingson, Nicholas Cho, Chencai Wang
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Monitoring And Recording Systems
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