Search Results - nicholas+peppas

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Recognitive biodegradable nanoparticles for targeted in vivo diagnostics and therapeutics
Recognitive biodegradable nanoparticles combine molecularly imprinted polymers with biodegradable cores to detect specific target molecules like proteins for in vivo diagnostics. They offer high affinity, selectivity, lower production costs, and reduced immunologic response. Background The field of molecularly imprinted polymers (MIPs) involves creating...
Published: 9/9/2024   |   Inventor(s): Nicholas Peppas, Heidi Culver
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Nanoscale, pH-responsive polycationic networks for targeted delivery of anionic biologic therapeutics
­This technology involves nanoscale, pH-responsive polycationic hydrogels for delivering anionic biologic therapeutics like siRNA. These hydrogels, made from crosslinked copolymers, trap therapeutics at physiological pH and release them in lower pH environments, enhancing biocompatibility and targeted delivery. Background The delivery of small...
Published: 9/6/2024   |   Inventor(s): Nicholas Peppas, William Liechty
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Biomaterials
Biomimetic polymer networks for selective binding and controlled delivery of therapeutic agents
Biomimetic polymer networks are specialized materials with molecular imprints that selectively bind specific molecules, enabling controlled loading and delivery of therapeutic agents, such as glucose, through tailored noncovalent interactions within a crosslinked polymer matrix. Background Achieving selective molecular recognition in synthetic materials...
Published: 8/19/2024   |   Inventor(s): Nicholas Peppas, Mark Byrne, James Hilt
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Polymeric network technology for controlled delivery of active agents
The technology involves a polymeric network designed for controlled delivery of active agents, triggered by the binding of specific molecules. This interaction reduces the structural integrity of the polymer at designated micro- or nanovacuoles, causing it to rupture and release the agents. Background Controlled delivery of active agents within polymeric...
Published: 8/19/2024   |   Inventor(s): Nicholas Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
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Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Resting-State Functional Magnetic Resonance Imaging Derived From Dynamic Perfusion Imaging (Case No. 2023-126)
Intro Sentence: UCLA researchers in the Department of Radiology have developed a novel method for obtaining simultaneous perfusion and functional MRI data from a single MRI acquisition to improve the diagnosis, monitoring, and management of brain tumors and stroke. Background: Advanced magnetic resonance imaging (MRI) techniques are crucial for...
Published: 8/23/2024   |   Inventor(s): Benjamin Ellingson, Nicholas Cho, Chencai Wang
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Monitoring And Recording Systems
Revolutionizing drug delivery: smart hydrogels for precise nanoparticle and siRNA intestinal release
Background Intelligent hydrogels, specifically environmentally responsive hydrogels, are emerging as promising biomaterials capable of responding to biological environments and processes. These materials offer tunability and bio­compatibility, making them valuable for various biomedical applications, including tissue regeneration and controlled...
Published: 4/12/2024   |   Inventor(s): Nicholas Peppas, Jennifer Knipe
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Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Recognitive hydrogel technology for precise molecular detection
Background The field of chemical sensor technology has long sought methods to accurately detect and measure molecular presence and concentration in various environments. A pervasive challenge has been developing sensors that can selectively recognize specific molecules in complex mixtures. Traditional sensors often struggle with non-specific binding,...
Published: 9/24/2024   |   Inventor(s): Nicholas Peppas, Carolyn Bayer
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Diagnostic