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pH-sensitive hydrogel technology for enhanced oral delivery of high molecular weight therapeutic proteins
This invention describes a pH-sensitive hydrogel for oral delivery of therapeutic proteins like factor VIII or IX, used in hemophilia treatment. It protects proteins in the stomach and releases them in the intestine, enhancing bioavailability. Background Delivering therapeutic proteins orally presents significant challenges due to the body's natural...
Published: 10/3/2024   |   Inventor(s): Nicholas Peppas, Sarena Horava
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery