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Targeting protein palmitoylation to suppress tumor growth and metastasis in triple negative breast cancer
Flotillin-1 palmitoylation is essential for its stability and tumor-promoting functions in triple-negative breast cancer (TNBC). Disrupting this process, either genetically or with targeted inhibitors, reduces tumor growth and metastasis, making it a potential therapeutic target. Background Triple negative breast cancer (TNBC) is a particularly aggressive...
Published: 8/8/2024   |   Inventor(s): Linda deGraffenried, Bryan McClellan
Keywords(s):  
Category(s): Life sciences > Therapeutics > Biologic
Improved drug delivery for solid tumors
A novel formulation paving the way for pancreatic cancer therapeutics Problem Pancreatic cancer therapeutics have a success rate of less than 8%. The solid nature of the tumor in pancreatic cancer renders the current standard of care, chemotherapy drugs, less effective. Unfortunately, the problem lies not with the drugs themselves, but with the drug...
Published: 11/1/2023   |   Inventor(s): Debadyuti Ghosh, Xinquan Liu
Keywords(s): Cancer, Drug delivery, Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Biologic