Search Results - life+sciences+%3e+therapeutics+%3e+biologic

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A chemical proteomics platform for identifying transcytosis receptors to enable oral delivery of biologics

This technology uses a novel chemical tagging method to identify intestinal receptors that transport biologic drugs across the gut barrier, enabling more effective oral delivery of large protein therapeutics that were previously only injectable. Background Oral delivery of biologic drugs, such as therapeutic proteins and antibodies, represents a major...

Published: 6/5/2026 | Updated: 6/5/2026 | Inventor(s): Brian Belardi, Isabela Ramirez-Velez

Keywords(s):

Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Research tools > Tool/assay/screening platform

Human-Enzyme Mediated, Depletion of Homocysteine for Treating Patients with Homocysteinemia/Homocystinuria

This technology uses engineered human enzymes with enhanced activity to efficiently break down toxic homocysteine, offering improved treatment for metabolic disorders like homocystinuria and hyperhomocysteinemia through enzyme therapy, gene therapy, or pharmaceutical formulations. Background Homocystinuria and hyperhomocysteinemia are inherited or...

Published: 6/4/2026 | Updated: 6/4/2026 | Inventor(s): Everett Stone, George Georgiou

Keywords(s):

Category(s): Life sciences > Therapeutics, Life sciences > Therapeutics > Biologic

Anti-CD160 Humanized Antibody

Engineered humanized anti-CD160 antibodies and derivatives for depleting CD160+ immune cells to attenuate inflammation Background: Adaptive immune responses contribute significantly to the progression of acute myocarditis, where overactivation of cytotoxic lymphocytes leads to myocardial injury and eventual heart failure. Targeting immune receptors...

Published: 6/4/2026 | Updated: 2/17/2026 | Inventor(s): Jennifer Maynard, Agata Turula

Keywords(s):

Category(s): Life sciences, Life sciences > Therapeutics > Biologic

Bifunctional fusion protein for biofilm degradation and quorum sensing disruption

Background Bacterial biofilms pose a major challenge in clinical and industrial environments due to their dense extracellular matrix and heightened tolerance to antibiotics and immune responses. Infections involving biofilms, particularly those caused by Pseudomonas aeruginosa, are difficult to eradicate and contribute to chronic wounds, persistent...

Published: 1/30/2026 | Updated: 1/30/2026 | Inventor(s): Hugh Smyth, Tom Smisek, Rex Moore, Nila Murali, John Schroeder, Walter Fast

Keywords(s):

Category(s): Life sciences > Therapeutics > Biologic

Efficient production and delivery of bioactive peptides via Gram-negative bacterial secretion system

Engineered Gram-negative bacteria use the microcin V secretion system to produce and release various active peptides efficiently. This versatile technology works across multiple bacterial species and preserves peptide functionality for research and therapeutic uses. Background The production and secretion of bioactive peptides are critical in...

Published: 1/13/2026 | Updated: 1/9/2025 | Inventor(s): Bryan Davies, Sun-Young Kim, Jennifer Parker

Keywords(s):

Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics > Synthetic biology

Lipid nanocarriers for promoting angiogenesis

This invention describes a new way to deliver a protein called transmembrane stem cell factor (tmSCF) using tiny carriers made of lipids (fats). This helps promote the growth of new blood vessels and could treat peripheral vascular disease. Background Peripheral vascular disease (PVD) affects a significant portion of the aging population, often leading...

Published: 1/13/2026 | Updated: 10/23/2024 | Inventor(s): Aaron Baker, Eri Takematsu

Keywords(s):

Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics

Mechanical conditioning for mesenchymal stem cell rejuvenation

This technology uses mechanical force to rejuvenate aged stem cells. It enhances cell function, reduces aging markers, and improves DNA repair, making the cells more suitable for regenerative therapies. Background Mesenchymal stem cells (MSCs) hold immense promise for regenerative medicine due to their availability, multipotency, and immunomodulatory...

Published: 1/13/2026 | Updated: 10/23/2024 | Inventor(s): Aaron Baker, Miles Massidda

Keywords(s):

Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Therapeutics > Biologic

Blood-brain barrier penetrant therapeutic delivery with biomacromolecule-tagged constructs

This technology uses nanoscale constructs tagged with biomacromolecules like peptides, nucleic acids, and carbohydrates to deliver therapeutic agents across the blood-brain barrier, enhancing drug delivery to the brain while minimizing off-target effects. Background The blood-brain barrier (BBB) is a critical physiological structure that serves to...

Published: 1/13/2026 | Updated: 10/16/2024 | Inventor(s): Cassandra Callmann, Cole Williams, Zamira Harris-Ryden, Muhammad Waqas Ishaq, Daniel Stone

Keywords(s):

Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Research tools > Tool/assay/screening platform

Hydrogel matrix technology for accelerating tissue-engineered dermal and vascular formation

A tissue-engineered dermal equivalent uses a hydrogel matrix with two distinct layers and mesenchymal stem cells (MSCs). One layer promotes blood vessel cell formation, while the other encourages dermal fibroblast development, facilitating vascular and dermal tissue creation from a single stem cell source. Background Severe skin injuries, such as...

Published: 6/4/2026 | Updated: 9/27/2024 | Inventor(s): Laura Suggs, Ge Zhang, Shanmugasundaram Natesan, Robert Christy, Thomas Walters

Keywords(s):

Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Biologic

A pharmaceutical compound for targeted cancer therapy using nucleobase analog derivatives with omega-3 fatty acids

The invention describes compounds combining nucleobase analogs with omega-3 fatty acids, enhancing cancer treatment efficacy, particularly for pancreatic cancer. These compounds improve stability and solubility and demonstrate significant anti-cancer activity, offering potential for targeted therapy. Background Pancreatic cancer presents a significant...

Published: 1/13/2026 | Updated: 9/27/2024 | Inventor(s): Zhengrong Cui, Dharmika Lansakara

Keywords(s):

Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Biologic

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