Search Results - aaron+baker

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Lipid nanocarriers for promoting angiogenesis
This invention describes a new way to deliver a protein called transmembrane stem cell factor (tmSCF) using tiny carriers made of lipids (fats). This helps promote the growth of new blood vessels and could treat peripheral vascular disease. Background Peripheral vascular disease (PVD) affects a significant portion of the aging population, often leading...
Published: 10/23/2024   |   Inventor(s): Aaron Baker, Eri Takematsu
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Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics
Mechanical conditioning for mesenchymal stem cell rejuvenation
This technology uses mechanical force to rejuvenate aged stem cells. It enhances cell function, reduces aging markers, and improves DNA repair, making the cells more suitable for regenerative therapies. Background Mesenchymal stem cells (MSCs) hold immense promise for regenerative medicine due to their availability, multipotency, and immunomodulatory...
Published: 10/23/2024   |   Inventor(s): Aaron Baker, Miles Massidda
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Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Therapeutics > Biologic
Biocompatible proteoliposome technology for enhanced wound healing and reduced inflammation in diabetic patients
Syndesomes—lipid vesicles with embedded syndecan-4 and PDGF-BB—enhance wound healing by promoting cellular activities, reducing inflamma­tion, and improving tissue regeneration. They are particularly effective in diabetic and obese models, supporting re-epithelialization and angiogenesis. Background Chronic non-healing wounds, particularly...
Published: 10/4/2024   |   Inventor(s): Aaron Baker, Subhamoy Das
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Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Agriculture > Animal/veterinary
Rhamnan sulfate therapy for NAFLD/NASH and circadian rhythm disorders
This invention describes compositions and methods for treatment of metabolic diseases and disorders, such as non-alcoholic fatty liver disease (NAFLD, NASH) and circadian rhythm-related disorders. Background/problem Rhamnan sulfate (RS) is a sulfated polysaccharide primarily composed of rhamnose, found in the green seaweed Monostroma nitidum. This...
Published: 11/5/2024   |   Inventor(s): Aaron Baker, Nikita Patil
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Category(s): Life sciences > Therapeutics > Formulation
High-throughput trans-well device incorporating shear stress for drug screening of blood-brain barrier function
Background Traditional trans-well assays have long been a fundamental component in cell biology, allowing researchers to study cell migration, permeability, and transport processes across a semi-permeable membrane. However, there is a growing recognition of the need to replicate more closely the dynamic environment of human tissues, including the blood-brain...
Published: 3/5/2024   |   Inventor(s): Aaron Baker, Daniel Chavarria
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Vascular regeneration using mechano-biologically conditioned mesenchymal stem cells
Mesenchymal stem cells (MSCs) are an appealing cell type for use in therapies for ischemia, but clinical trials have not yielded consistent benefits for patients. In their current form, MSC therapies are ineffective and unreliable, particularly for patients who have suffered a myocardial infarction. Work done by Dr. Baker and his team overcomes many...
Published: 4/5/2024   |   Inventor(s): Aaron Baker, Jason Lee
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug screening