Search Results - bryan+davies

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Engineered bacterial platform for in situ mRNA delivery to mammalian cells
Background Genetic medicine depends on the ability to deliver messenger RNA (mRNA) into mammalian cells to enable therapeutic protein expression, correct genetic defects, or produce antigens for vaccines. But current delivery systems face critical barriers that limit their clinical utility. DNA plasmid-based approaches often show poor transfection...
Published: 10/7/2025   |   Inventor(s): Bryan Davies, Christopher Sullivan, Andrew Ellington
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
Engineered microbial antigen-presenting system for targeted T cell activation
Background Targeted immunotherapy depends on the ability to modulate specific T cell populations to fight chronic infections, cancers, and autoimmune diseases. Achieving precise control over T cell activation is essential for generating effective immune responses while minimizing off-target effects. Traditional vaccines and existing antigen-presenting...
Published: 10/2/2025   |   Inventor(s): Bryan Davies, Rita Ousterhout
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
Three-component secretion system for extracellular delivery of folded proteins in gram-negative bacteria
Background Efficient production and secretion of functional proteins are essential to a wide range of applications in biotechnology and medicine, from therapeutic protein delivery to industrial enzyme manufacturing. Gram-negative bacteria such as E. coli are commonly used expression hosts due to their rapid growth, affordability, and genetic flexibility. However,...
Published: 10/2/2025   |   Inventor(s): Bryan Davies, Kyra Groover
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Manufacturing platform
Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum. Technology Summary Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025   |   Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
Efficient production and delivery of bioactive peptides via Gram-negative bacterial secretion system
Engineered Gram-negative bacteria use the microcin V secretion system to produce and release various active peptides efficiently. This versatile tech­nology works across multiple bacterial species and preserves peptide functionality for research and therapeutic uses. Background The production and secretion of bioactive peptides are critical in...
Published: 7/2/2025   |   Inventor(s): Bryan Davies, Sun-Young Kim, Jennifer Parker
Keywords(s):  
Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics > Synthetic biology
Ammonium compounds for gut microbiome modulation
The technology involves the development of quaternary ammonium compounds with antimicrobial properties, effective against various bacteria and fungi, including multidrug-resistant strains. These compounds concentrate activity in the gastrointestinal tract, minimizing systemic exposure and potential side effects, making them suitable for conditions like...
Published: 9/6/2024   |   Inventor(s): Bryan Davies, Stanton McHardy, Ashley Cunningham, Hua-Yu Wang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Future drug-delivery system to treat brain tumors
Background/problem Glioblastoma (GBM) is the most common malignant, primary brain tumor observed in adults, occurring at an incidence rate of 3.19 per 100,000 persons in the United States in 2017. Even with complete surgical resection of the tumor and adjuvant chemotherapy, these tumors often reoccur, resulting in a median survival of ~15 months. Part...
Published: 6/2/2025   |   Inventor(s): Benjamin Umlauf, Bryan Davies, Austin Shipley, Gabriel Frampton
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery