Search Results - life+sciences+%3e+metabolic+engineering

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Biocompatible photoenzymatic system for selective C–H fluorination
Background C–H fluorination plays a central role in pharmaceutical and agrochemical synthesis, as the introduction of fluorine often enhances a molecule's metabolic stability, potency, and bioavailability. Over 20% of approved drugs contain fluorinated functional groups, underscoring the demand for efficient and selective fluorination methods....
Published: 7/31/2025   |   Inventor(s): Yi Lu, Yu Zhou
Keywords(s):  
Category(s): Life sciences > Metabolic engineering
Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor micro­environ­ment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
Published: 6/16/2025   |   Inventor(s): Everett Stone, Max Rodnick-Smith, Ranya Al-Khaledy, George Georgiou
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Metabolic engineering
Artificial nitrogenase enzymes for ambient-condition, decentralized ammonia production
Background Ammonia synthesis is foundational to global agriculture and chemical manufacturing, providing the primary source of fixed nitrogen for fertilizers, polymers, and pharmaceuticals. Traditional ammonia production through the Haber-Bosch process, however, operates under extreme conditions—temperatures exceeding 400°C and pressures...
Published: 7/2/2025   |   Inventor(s): Yi Lu, Hirbod Heidari, Markus Ribbe, Yilin Hu, Chi Chung Lee, Evan Mirts
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering
DNA synthesis method using template switching for detection and sequence analysis
A method to create DNA copies of specific genetic material using primers and enzymes, enabling easier detection, amplification, cloning, and sequencing of DNA and RNA. Background Advancements in molecular biology have underscored the critical need for efficient and accurate methods to prepare DNA copies of target polynucleo­tides. Techniques such...
Published: 1/31/2025   |   Inventor(s): Alan Lambowitz, Sabine Mohr, Travis White, Robert Kuersten
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Metabolic engineering
Stabilized reverse transcriptase fusion proteins for reliable nucleic acid amplification
A stable enzyme is created by combining reverse transcriptase with a stabilizing protein, enhancing its durability and performance for DNA amplification methods like RT-PCR Background Reverse transcription is a cornerstone technique in molecular biology, facilitating the conversion of RNA into comple­mentary DNA (cDNA) for various applications...
Published: 1/31/2025   |   Inventor(s): Alan Lambowitz, Sabine Mohr, Georg Mohr, Eman Ghanem
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Metabolic engineering
Producing modified lipid A bacterial vaccine components
Engineered bacteria are designed to produce modified lipid A with reduced toxicity and either polypeptide or polysaccharide antigens, which can be used in vaccines to elicit targeted immune responses. Background The challenge of developing effective vaccines against bacterial infections lies in the dual necessity of eliciting a robust immune response...
Published: 9/13/2024   |   Inventor(s): Michael Trent, Joseph Boll
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Vaccines
Biotechnological approach for cancer treatment through kynurenine depletion using engineered enzymes​​​​​
This invention describes engineered kynureninase enzymes that degrade kynurenine, a metabolite linked to cancer progression. These enzymes, optimized for human therapy, can be modified with polyethylene glycol to enhance stability and circulation, offering potential in cancer treatment when combined with other therapies like immunotherapy. Background Cancer...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Enhanced cancer treatment through methionine depletion
The invention involves engineering a modified human cystathionine-γ-lyase enzyme to degrade methionine, an amino acid essential for cancer cell growth. This modified enzyme, with specific amino acid substitutions, offers enhanced catalytic activity, stability, and reduced immunogenicity, making it suitable for cancer treatment by depleting methionine...
Published: 6/27/2025   |   Inventor(s): George Georgiou, Everett Stone, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Metabolic engineering of Yarrowia lipolytica for high‑level polyketide production
Background The field of biotechnology has seen significant advancements in the use of genetically modified organisms to produce valuable compounds. Polyketides, a diverse class of secondary metabolites, are of particular interest due to their wide-ranging applications in pharmaceuticals, bioactive compounds, and renewable chemicals. Traditional methods...
Published: 7/11/2024   |   Inventor(s): Hal Alper, Kelly Markham, Claire Palmer
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Revolutionizing plastic recycling: FAST-PETase enzyme variant
Background Plastic waste is a pressing ecological challenge, with a staggering 8.3 billion metric tons produced, of which 6 billion tons become waste. Traditional methods of plastic degradation, such as chemical processes, are costly and generate harmful byproducts. Enzymatic degradation presents a sustainable alternative, with poly (ethylene terephthalate)...
Published: 6/11/2025   |   Inventor(s): Hal Alper, Andrew Ellington, Daniel Diaz, Hongyuan Lu
Keywords(s):  
Category(s): Life sciences > Agriculture, Life sciences > Metabolic engineering
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