Search Results - life+sciences+%3e+metabolic+engineering

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Producing modified lipid A bacterial vaccine components
Engineered bacteria are designed to produce modified lipid A with reduced toxicity and either polypeptide or polysaccharide antigens, which can be used in vaccines to elicit targeted immune responses. Background The challenge of developing effective vaccines against bacterial infections lies in the dual necessity of eliciting a robust immune response...
Published: 9/13/2024   |   Inventor(s): Michael Trent, Joseph Boll
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Vaccines
Biotechnological approach for cancer treatment through kynurenine depletion using engineered enzymes​​​​​
This invention describes engineered kynureninase enzymes that degrade kynurenine, a metabolite linked to cancer progression. These enzymes, optimized for human therapy, can be modified with polyethylene glycol to enhance stability and circulation, offering potential in cancer treatment when combined with other therapies like immunotherapy. Background Cancer...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Enhanced cancer treatment through methionine depletion
The invention involves engineering a modified human cystathionine-γ-lyase enzyme to degrade methionine, an amino acid essential for cancer cell growth. This modified enzyme, with specific amino acid substitutions, offers enhanced catalytic activity, stability, and reduced immunogenicity, making it suitable for cancer treatment by depleting methionine...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Engineered enzymes for treating cancer and severe combined immunodeficiency
The technology describes engineered methylthioadenosine (MTA) and adenosine (ADO)-degrading enzymes from either prokaryotic or mammalian sources to be used in pharmaceutical formulations to treat cancer or severe combined immunodeficiency (SCID) by enhancing pharmacological properties like serum stability and reducing immunogenicity. Background The...
Published: 9/10/2024   |   Inventor(s): Everett Stone
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Metabolic engineering
Engineered sugar uptake in yeast cells
The technology focuses on engineered transporter proteins that enhance the uptake of specific monosaccharides like xylose and arabinose into yeast cells, improving their efficiency and selectivity for biofuel and biochemical production. Background The efficient conversion of lignocellulosic biomass into biofuels and bio­chemicals is a critical...
Published: 8/15/2024   |   Inventor(s): Hal Alper, Eric Young
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Research tools, Physical sciences > Energy > Renewable
Metabolic engineering of Yarrowia lipolytica for high‑level polyketide production
Background The field of biotechnology has seen significant advancements in the use of genetically modified organisms to produce valuable compounds. Polyketides, a diverse class of secondary metabolites, are of particular interest due to their wide-ranging applications in pharmaceuticals, bioactive compounds, and renewable chemicals. Traditional methods...
Published: 7/11/2024   |   Inventor(s): Hal Alper, Kelly Markham, Claire Palmer
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Revolutionizing plastic recycling: FAST-PETase enzyme variant
Background Plastic waste is a pressing ecological challenge, with a staggering 8.3 billion metric tons produced, of which 6 billion tons become waste. Traditional methods of plastic degradation, such as chemical processes, are costly and generate harmful byproducts. Enzymatic degradation presents a sustainable alternative, with poly (ethylene terephthalate)...
Published: 3/4/2024   |   Inventor(s): Hal Alper, Andrew Ellington, Daniel Diaz, Hongyuan Lu
Keywords(s):  
Category(s): Life sciences > Agriculture, Life sciences > Metabolic engineering
Degradons: target proteins for degradation without ubiquitination
Problem Targeting specific proteins for degradation is an area of intense research for the treatment of disease. The majority of currently available technologies, such as PROTACs, induce degradation through ubiquitination of target proteins by binding to both the target protein and ubiquitin ligases. However, this requires a ubiquitin ligase to efficiently...
Published: 1/9/2024   |   Inventor(s): Andreas Matouschek
Keywords(s):  
Category(s): Life sciences > Research tools, Life sciences > Metabolic engineering