Search Results - max+rodnick-smith

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Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor micro­environ­ment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
Published: 6/16/2025   |   Inventor(s): Everett Stone, Max Rodnick-Smith, Ranya Al-Khaledy, George Georgiou
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Metabolic engineering
Pressure Drop Estimation from Blood Flow Profiles
Summary A method for accurate, efficient and non-invasive assessment of the pressure drop in the cardiovascular systemusing time-varying blood velocity profiles from from any flow imaging techniques. This technology will improve the screening power of current clinical practice and will reduce the need for catheterisation procedures. What A technology...
Published: 1/8/2025   |   Inventor(s): Pablo Lamata de la Orden, David Nordsletten, Fabrizio Donati, Nic Smith
Keywords(s):  
Category(s): Diagnostics, Software