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Engineered orthogonal elongation factor for SECIS-independent noncanonical amino acid incorporation
Background Selenocysteine (Sec), the 21st amino acid, offers unique redox and catalytic properties that are valuable for biocatalysis, therapeutic protein engineering, and redox biology. However, its use in synthetic biology and protein engineering has been restricted by the complexity of its natural biosynthetic machinery. Sec incorporation typically...
Published: 1/13/2026   |   Inventor(s): Andrew Ellington, Satoshi Ishida
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering