Search Results - ranya+al-khaledy

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Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor micro­environ­ment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
Published: 6/16/2025   |   Inventor(s): Everett Stone, Max Rodnick-Smith, Ranya Al-Khaledy, George Georgiou
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Metabolic engineering