Search Results - life+sciences+%3e+immunology

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Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data. Background Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
Published: 10/22/2024   |   Inventor(s): Gregory Ippolito, Jonathan McDaniel, William Voss, George Georgiou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
Engineered antibodies for enhanced immune response
Recombinant antibodies with engineered human IgG1 Fc domains have been developed to resist viral Fc receptor capture, enhancing immune targeting of virus-infected cells. These antibodies maintain normal host receptor affinity, potentially improving therapeutic outcomes against HCMV and related viruses. Background Human cytomegalovirus (HCMV) infection...
Published: 11/5/2024   |   Inventor(s): Jennifer Maynard, Ahlam Qerqez
Keywords(s):  
Category(s): Life sciences > Immunology
Monoclonal antibodies for the conserved feature of the coronavirus spike protein
The invention describes monoclonal antibodies targeting conserved epitopes on the S2 domain of coronavirus spike proteins, potentially useful for preventing or treating infections by inhibiting viral entry. These antibodies could aid in therapeutic formulations against coronaviruses like SARS-CoV-2, SARS-CoV, and MERS-CoV. Background The emergence...
Published: 10/16/2024   |   Inventor(s): Jennifer Maynard, Yimin Huang, Annalee Nguyen, Ching-Lin Hsieh, Jason McLellan, Eduardo Padlan
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Therapeutics > Vaccines
Methodology for high-throughput sequencing of paired antibody transcripts from B cells
The technology enables rapid and accurate sequencing of paired VH and VL antibody transcripts from single antigen-specific B cells. It involves isolating B cells, capturing their mRNA and antibodies, forming complexes with affinity agents, purifying these complexes, and performing RT-PCR to generate and sequence cDNA, facilitating various immunological...
Published: 9/16/2024   |   Inventor(s): George Georgiou, Erik Johnson
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
Published: 9/13/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Dual-target defense: bispecific antibodies revolutionize pertussis toxin neutralization
­Bispecific antibodies target two epitopes on the pertussis toxin protein, enhancing toxin neutralization. Engineered using “knobs-into-holes” tech­nology, they form stable heterodimers, offering similar efficacy to antibody mixtures but with streamlined manufacturing and regulatory benefits. Background Pertussis, or whooping cough,...
Published: 9/6/2024   |   Inventor(s): Jennifer Maynard, Ellen Wagner
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Immunology
Treating respiratory diseases and whooping cough
This technology involves compositions and methods for treating respiratory diseases like whooping cough and includes immunization techniques. Background The field of respiratory disease treatment and immunization is important due to the significant health burden posed by conditions such as whooping cough. Whooping cough, or pertussis, is a highly...
Published: 8/8/2024   |   Inventor(s): Jennifer Maynard, Jamie Sutherland, Matthew Croughan
Keywords(s):  
Category(s): Life sciences > Therapeutics > Vaccines, Life sciences > Immunology
High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
Published: 8/7/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Chenfeng He, Keyue Ma
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
Innovative pH-selective antibody engineering for cancer therapy
Background Antibody-based cancer therapies have demonstrated impressive specificity but can lead to adverse effects by targeting antigens present on healthy cells. The acidic tumor microenvironment presents an opportunity for the development of anti­bodies with heightened tumor specificity through pH-dependent binding interactions. Technology...
Published: 5/3/2024   |   Inventor(s): Jennifer Maynard, Yutong Liu, Annalee Nguyen
Keywords(s):  
Category(s): Life sciences > Immunology
Method for detecting antibodies to folic acid
Background Folate, an essential B-vitamin, is crucial for a variety of health-related functions. The recognition that too few women obtained sufficient folate levels from their diet and knowing that a folate deficiency put embryos at risk for serious birth defects led to mandatory fortification of certain foods to prevent deficiencies. Such preventive...
Published: 4/16/2024   |   Inventor(s): Richard Finnell, Robert Cabrera
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Immunology