Search Results - chenfeng+he

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LORI: Local Low-Rank Imputation for Context-Aware AI
THE CHALLENGE Leveraging Artificial Intelligence (AI) for data-driven decision-making faces a major challenge in automatically configuring and optimizing complex AI pipelines across different use cases. As organizations deal with diverse datasets and fast-changing requirements, selecting the right combination of processing steps becomes increasingly...
Published: 4/16/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Software
Attention-on-Attention for Human-Guided AI
THE CHALLENGE A major challenge facing industries like advanced manufacturing and quality inspection is the gap between human expertise in visual search and the limited capabilities of current AI systems. While skilled inspectors can dynamically scan, interpret, and integrate subtle visual cues over time, most existing automated solutions rely on static...
Published: 4/16/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Communication, Technology Classifications > Software
All Temp. Rechargeable Solid State Lithium Batteries
THE CHALLENGE The challenge in advancing lithium metal batteries lies in developing solid electrolytes that not only perform reliably but also meet market demands for safety, durability, and scalability. Current materials—such as liquid electrolytes and polymer gels—either pose serious safety risks like leakage and flammability or degrade...
Published: 4/16/2025   |   Inventor(s): Louis Madsen, Feng Lin, Deyang Yu
Keywords(s):  
Category(s): Technology Classifications > Energy
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Silicon-CdTe-Halide Perovskite Triple-Junction Solar Cell
Background Solar energy is one of the most abundant and affordable energies in the world. However, converting solar energy into electricity significantly relies on the power conversion efficiency of the solar cell’s technology. Due to the current limitations of the various materials and physics in the solar cell’s technology, it is a great...
Published: 2/28/2025   |   Inventor(s): Feng Yan, Yanfa Yan
Keywords(s):  
Category(s): Energy & Power, Advanced Materials/Nanotechnology, Physical Science
Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
Published: 9/13/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 9/10/2024   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials
The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses
Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...
Published: 9/6/2024   |   Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen
Keywords(s): Biomedical, Human Health, Pharma, Research, Veterinary Medicine
Category(s): Biotechnology, Biomedical, Pharma, Veterinary Medicine
High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
Published: 8/7/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Chenfeng He, Keyue Ma
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
YAP-TEAD Core Inhibitors for Developing Cancer Therapeutics
Inhibit YAP-TEAD Interactions for the Treatment of Diseases with Altered Hippo Signaling These small molecule inhibitors target TEA domain (TEAD) proteins, with the potential to treat diseases with altered Hippo signaling, such as Hepatocellular Carcinoma (HCC) and Hepatoblastoma (HB). The Hippo signaling pathway is vital to organ growth control, stem...
Published: 9/3/2024   |   Inventor(s): Chenglong Li, Chen Zhou, Liya Pi, Chunbao Sun
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
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