Search Results - chenfeng+he

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Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
Published: 9/13/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 9/10/2024   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials
The Y161F Substitution of Hemagglutinin Increases Antigenic Thermostability and Improves Yields of Influenza A Viruses
Background Vaccination has been the most efficient and economical strategy for preventing influenza virus infection and controlling disease spread among hosts. A high yield vaccine seed strain is required for timely vaccine manufacture and is thus a critical component of a successful influenza vaccination program. Unfortunately, it is not uncommon...
Published: 9/6/2024   |   Inventor(s): Xiu-Feng (Henry) Wan, Feng Wen
Keywords(s): Biomedical, Human Health, Pharma, Research, Veterinary Medicine
Category(s): Biotechnology, Biomedical, Pharma, Veterinary Medicine
High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
Published: 8/7/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Chenfeng He, Keyue Ma
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
YAP-TEAD Core Inhibitors for Developing Cancer Therapeutics
Inhibit YAP-TEAD Interactions for the Treatment of Diseases with Altered Hippo Signaling These small molecule inhibitors target TEA domain (TEAD) proteins, with the potential to treat diseases with altered Hippo signaling, such as Hepatocellular Carcinoma (HCC) and Hepatoblastoma (HB). The Hippo signaling pathway is vital to organ growth control, stem...
Published: 9/3/2024   |   Inventor(s): Chenglong Li, Chen Zhou, Liya Pi, Chunbao Sun
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
National Hydrologic Simulation Database
This database includes simulation input and outputs from the ParFlow CONUS 1 and 2 models for use in connection with the HydroGEN system for hydrological modeling. More information on these models can be found at https://hydroframe.org/parflow-conus1 and https://hydroframe.org/parflow-conus2. ParFlow is one of the most physically rigorous hydrologic...
Published: 8/23/2024   |   Inventor(s): Laura Condon, Andrew Bennett, Amy Johnson, Reed Maxwell, William Hasling, Amy Defnet, Danielle Tijerina, Chen Yang
Keywords(s):  
Category(s): Technology Classifications > Energy, Cleantech & Environmental, Technology Classifications > Software & Information Technology, Technology Classifications > Software & Information Technology > Databases & Data Mining, Technology Classifications > Agriculture & Horticulture
Inhaled formulations of the NSAID indomethacin
Background Patients suffering from headache and migraine have a limited list of thera­peutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
Published: 5/8/2024   |   Inventor(s): Hugh Smyth, Feng Zhang, Jamie Spahn
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Manufacturing platform
Simulation-based Real-time Production Control
In many production systems like semiconductor manufacturing, food industry, and battery production, the amount of time a part can spend in successive buffers is limited in many production systems because of possible quality concerns. If a part's residence time exceeds these limits, it must be trashed, which results in waste and lost output. To prevent...
Published: 6/5/2024   |   Inventor(s): Feng Ju, Feifan Wang
Keywords(s): Algorithm Development, Machine Learning, Manufacturing, PS-Manufacturing,Construction,Mechanical, Real-Time System
Category(s): Manufacturing/Construction/Mechanical, Physical Science, Computing & Information Technology
Machine Learning Algorithm for Inferring User Activities from IoT Device Events
The ubiquitous and heterogeneous deployment of internet of things (IoT) devices in smart homes has created new opportunities to extract knowledge, awareness, and intelligence via monitoring and understanding the devices’ interactions with their environments and users. Meaningful information from network traffic of IoT devices in smart homes can...
Published: 2/14/2024   |   Inventor(s): Guoliang Xue, Yinxin Wan, Kuai Xu, Feng Wang, Xuanli Lin
Keywords(s): Algorithm Development, Internet of Things, Machine Learning, Networks, IT, Software and Communication, PS-Computing and Information Technology, PS-Wireless and Networking, Security
Category(s): Computing & Information Technology, Physical Science, Wireless & Networking
An Automatic Configuration Method for Testing Integrated Circuits Independent of Chip Package Configuration
­Advantages: Automated testing assures consistent reliability in integrated circuits, meeting stringent industry standards. System efficiency is heightened by omitting external circuits, reducing overall setup time. Adaptable technology accommodates diverse chip configurations, seamlessly handling varied power and data. Summary: In the rapidly...
Published: 8/16/2024   |   Inventor(s): Cong Xu, Yunghsiao (Steven) Chung, Feng Yu, Liwei Xu, Stephen Saddow
Keywords(s): Electronics, Sensors
Category(s): Technology Classifications > Electronics > Electronics Sensors, Technology Classifications > Engineering > Electrical Engineering, Technology Classifications > Engineering > Manufacturing
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