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Search Results - jennifer+maynard
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Engineered antibodies for enhanced immune response
Recombinant antibodies with engineered human IgG1 Fc domains have been developed to resist viral Fc receptor capture, enhancing immune targeting of virus-infected cells. These antibodies maintain normal host receptor affinity, potentially improving therapeutic outcomes against HCMV and related viruses. Background Human cytomegalovirus (HCMV) infection...
Published: 11/5/2024
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Inventor(s):
Jennifer Maynard
,
Ahlam Qerqez
Keywords(s):
Category(s):
Life sciences > Immunology
Monoclonal antibodies for the conserved feature of the coronavirus spike protein
The invention describes monoclonal antibodies targeting conserved epitopes on the S2 domain of coronavirus spike proteins, potentially useful for preventing or treating infections by inhibiting viral entry. These antibodies could aid in therapeutic formulations against coronaviruses like SARS-CoV-2, SARS-CoV, and MERS-CoV. Background The emergence...
Published: 10/16/2024
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Inventor(s):
Jennifer Maynard
,
Yimin Huang
,
Annalee Nguyen
,
Ching-Lin Hsieh
,
Jason McLellan
,
Eduardo Padlan
Keywords(s):
Category(s):
Life sciences > Immunology
,
Life sciences > Therapeutics > Vaccines
Engineered polypeptides for enhanced integrin binding and antigen delivery
Engineered recombinant Invasin polypeptides have been modified to enhance integrin binding and resist intestinal proteolysis, facilitating effective oral delivery of therapeutics, such as vaccines, by targeting M cells in the gut for improved immune responses. Background The challenge of delivering therapeutics such as vaccines effectively across...
Published: 9/13/2024
|
Inventor(s):
Jennifer Maynard
,
Xianzhe Wang
,
Tarik Khan
Keywords(s):
Category(s):
Life sciences > Therapeutics > Vaccines
,
Life sciences > Agriculture > Animal/veterinary
,
Life sciences > Therapeutics > Drug delivery
Dual-target defense: bispecific antibodies revolutionize pertussis toxin neutralization
Bispecific antibodies target two epitopes on the pertussis toxin protein, enhancing toxin neutralization. Engineered using “knobs-into-holes” technology, they form stable heterodimers, offering similar efficacy to antibody mixtures but with streamlined manufacturing and regulatory benefits. Background Pertussis, or whooping cough,...
Published: 9/6/2024
|
Inventor(s):
Jennifer Maynard
,
Ellen Wagner
Keywords(s):
Category(s):
Life sciences > Therapeutics > Gene therapy
,
Life sciences > Immunology
Treating respiratory diseases and whooping cough
This technology involves compositions and methods for treating respiratory diseases like whooping cough and includes immunization techniques. Background The field of respiratory disease treatment and immunization is important due to the significant health burden posed by conditions such as whooping cough. Whooping cough, or pertussis, is a highly...
Published: 8/8/2024
|
Inventor(s):
Jennifer Maynard
,
Jamie Sutherland
,
Matthew Croughan
Keywords(s):
Category(s):
Life sciences > Therapeutics > Vaccines
,
Life sciences > Immunology
Innovative pH-selective antibody engineering for cancer therapy
Background Antibody-based cancer therapies have demonstrated impressive specificity but can lead to adverse effects by targeting antigens present on healthy cells. The acidic tumor microenvironment presents an opportunity for the development of antibodies with heightened tumor specificity through pH-dependent binding interactions. Technology...
Published: 5/3/2024
|
Inventor(s):
Jennifer Maynard
,
Yutong Liu
,
Annalee Nguyen
Keywords(s):
Category(s):
Life sciences > Immunology