Search Results - life+science+(all+ls+techs)

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Rapid Tuberculosis and Mycobacteria Phenotypic Drug Susceptibility Testing
Mycobacterium tuberculosis (TB) remains a major global health threat, causing nearly 1.5 million deaths annually, making it the 13th leading cause of death. While TB is preventable and treatable, multidrug-resistant TB worsens the global health crisis, making diagnosis and treatment more complex. An even greater challenge is heteroresistance, where...
Published: 4/8/2025   |   Inventor(s): Shelley Haydel, Shaopeng Wang, Jiapei Jiang, Yannik Haller
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Vaccines/Antimicrobials, Life Science (All LS Techs), Imaging, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices
Device to Attract and Trap Motile Aquatic Pathogens
The Caribbean region is considered a coral disease hotspot, with over 20 documented diseases and syndromes affecting over 20 species of corals. One motile marine pathogen family, Vibrionaceae, which is responsible for 50% of coral diseases, is strongly thermodependent, thus warming sea-surface temperatures, driven by pollution and global climate change,...
Published: 4/5/2025   |   Inventor(s): Liza Roger
Keywords(s):  
Category(s): Environmental, Environmental Remediation/Wastewater Treatment, Life Science (All LS Techs), Manufacturing/Construction/Mechanical
DNA/RNA Origami Assembly Mediated by Functional Peptides
DNA and RNA nanostructures, e.g., DNA Origami, have great potential in biological applications, including extracellular matrix scaffolds and delivery vehicles for drugs and gene therapies. While folding DNA origami under physiological conditions is plausible, significant challenges and limitations remain. For example, isothermal annealing of DNA origami...
Published: 4/2/2025   |   Inventor(s): Di Liu, Bing Xu, Zhishang Li, Jiaqi Guo
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biological Nanotechnology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Nucleic Acid/Peptide/Protein Therapies
A novel Scaffold for Mode-Selective Inhibition of TRPV1
Pain is estimated to affect about 30% of the world’s population and treatment is challenging because of issues with addiction and withdrawal which accompany many current analgesics. Human TRPV1 is a widely expressed nociceptor and is a desirable target to modulate diverse human pathophysiologies, including pain, obesity, and diabetes, among others....
Published: 4/2/2025   |   Inventor(s): Wade Van Horn, Pankaj J. Pasricha
Keywords(s):  
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Advanced Materials/Nanotechnology, Artificial Intelligence/Machine Learning, Biomaterials
Enhanced Combinatorial Oncolytic Virotherapy
Oncolytic viruses (OVs) are able to selectively infect and kill cancer cells without damaging normal cells. They can be used as a monotherapy, or they can be combined with existing cancer therapeutics for increased potency. While much progress has been made around OVs, one of their biggest limitations is their inability to successfully replicate, spread,...
Published: 3/31/2025   |   Inventor(s): Mohammed Masmudur Rahman
Keywords(s):  
Category(s): Cancer, Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals
CNN Architecture for Disease Identification from Retinal Images
The rise of artificial intelligence is changing the shape of many different fields, and ophthalmic medicine is no exception. Convolutional neural networks (CNNs) have achieved remarkable results in the assisted diagnosis of ophthalmic diseases. However, they face challenges such as limited labeling and small dataset sizes. In recent years, self-supervised...
Published: 3/19/2025   |   Inventor(s): Yalin Wang, Xin Li, Wenhui Zhu, Oana Dumitrascu
Keywords(s): Medical Devices and Imaging, Medical Software
Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Imaging, Life Science (All LS Techs), Medical Imaging
Affinity Encoded Nano-Oscillator Array
Nanoarray-based assays offer advantages over standard microarray assays such as minimal sample consumption, high efficiency, and enhanced multiplexing capacity. However, despite their potential, they face challenges such as the complexity and high cost of spotting and fabrication, as well as a lack of effective detection schemes. This impedes many practical...
Published: 3/4/2025   |   Inventor(s): Shaopeng Wang, Shuo-Hui Cao
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Life Science (All LS Techs), Imaging, Proteomic Assays/Reagents/Tools, Chemical/Biological Sensors
Jellyfish Polyp Bait-Trap
As coastal or nearshore environments experience rising sea levels, warming and acidification in addition to pollution from upland watersheds, coastal cities, and industrial development, ecosystems are significantly impacted. While this is happening on a global scale, monitoring as well as solutions and mitigations need to be enacted at the local level....
Published: 4/3/2025   |   Inventor(s): Natalia Figueroa, Liza Roger, Cheryl Ames, Meghan Maloney, Katherine Buckley, Andre Morandini, José M. Figueroa Conde
Keywords(s):  
Category(s): Environmental, Manufacturing/Construction/Mechanical, Life Science (All LS Techs), Educational
Biomaterial for Preventing Postoperative Intestinal Adhesions
Intra-abdominal adhesions, also known as postoperative peritoneal adhesions (PPA) remain a challenging issue in the US healthcare system. It is estimated that over 90% of gastrointestinal (GI) surgical procedures result in PPA formation, regardless of the location or surgical technique used. PPAs can also develop in response to tissue damage caused...
Published: 2/20/2025   |   Inventor(s): Kaushal Rege, Vanshika Singh, Muhammad Raisul Abedin, Jordan Yaron
Keywords(s):  
Category(s): Biomaterials, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices
Metabolic Reprogramming of Immune for Autoimmune Disorders Prevention/Reversal
Antigen-specific immune suppression or tolerance is a highly attractive strategy to prevent inflammation-induced tissue damage in rheumatoid arthritis (RA). Although there is insufficient knowledge about autoantigens in human RA, generating and expanding synovium-specific regulatory T cells, and suppressing synovium-specific follicular T-helper cells,...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya, Joslyn Mangal
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals
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