Search Results - life+science+(all+ls+techs)

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GLIMMER: Advanced Blood Glucose Prediction Model for Type 1 Diabetes
Invention Description Type 1 diabetes (T1D) is an autoimmune disease where the body attacks and destroys insulin-producing beta cells in the pancreas and affects nearly 10 million people globally. Because glucose needs to be continuously monitored for precise insulin dosing, managing T1D is challenging. While automated insulin delivery (AID) systems...
Published: 10/10/2025   |   Inventor(s): Hassan Zadeh, Saman Khamesian
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs), Medical Devices, Educational
Brassiere for the Treatment of Mastalgia and Breast Asymmetry
Invention Description Breast pain (mastalgia) can be attributed to many things, including hormones, diseases, breast asymmetry and improper breast support. Mastalgia is very common, affecting up to 70% of women across the globe at some point in their lives. Current remedies, including anti-inflammatories and hormonal treatments address symptoms but...
Published: 10/7/2025   |   Inventor(s): Rajpal Tiger, Vikram Kodibagkar, Grant Lindstrom, Brode Fendley, Nicholas Jimenez, William Hack, Cullanete Bloom
Keywords(s):  
Category(s): Life Science (All LS Techs), Medical Devices
Switchable mRNA Expression Platform
Invention Description While recent advances have made RNA therapeutics and vaccines more mainstream, they still suffer from drawbacks including high-dosing requirements and the inability for conditional and targeted expression. Further, they can experience off-target gene expression and related side effects as well as challenges in tissue- or cell-specific...
Published: 10/2/2025   |   Inventor(s): Petr Sulc, Mark Knappenberger, Archana Kikla, Matthew Sample, Karen Anderson
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Non-Cancer Therapeutics, Pharmaceuticals, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Microfluidic Device Design for Point-of-Care Devices
Implementing liquid-based assays, such as PCR and LAMP, is difficult in POC microfluidic devices, due to bubble formation. To mitigate this, auxiliary metering systems or actuators are required to regulate consistent flow rates. This can make the microfluidic device more complicated to operate, increases cost, and limits rapid prototyping, ultimately...
Published: 9/29/2025   |   Inventor(s): Vi Nguyen, Jennifer Blain Christen
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Diagnostics/Sensors, Genomic Assays/Reagents/Tools
POC-Pure: Rapid, Cost-Effective Nucleic Acid Extraction for Point-of-Care Salivary Diagnostics on a Microfluidic Chip
Point-of-care (POC) testing techniques are essential in molecular diagnostics, particularly in resource-limited settings. The first step in molecular diagnostics is sample preparation which may include extraction of nucleic acids (NAs). Simple and efficient NA extraction is crucial for downstream applications such as pathogen detection, genetic analysis,...
Published: 9/18/2025   |   Inventor(s): Siril Arockiam, Karen Anderson
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Medical Diagnostics/Sensors
SiMPLE: A Low-Cost, Scalable Method for High-Density DNA Origami Nanoarray Fabrication
Single-molecule techniques make it possible to digitally count even extremely rare biomarker molecules, providing greatly improved sensitivity for early disease detection. However, in standard setups, there is a necessary balance: if the concentration is too high, molecules overlap and become unreadable; if too low, there are not enough events for robust...
Published: 9/2/2025   |   Inventor(s): Prathamesh Chopade, Rizal Hariadi, Deeksha Satyabola, Aaron Sakai
Keywords(s):  
Category(s): Biological Nanotechnology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Nucleic Acid/Peptide/Protein Therapies
Brain-Targeted Nanoparticles for Delivering Agents to the Brain
The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...
Published: 8/27/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Biological Nanotechnology, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Pharmaceuticals, Medical Imaging, Non-Cancer Therapeutics
Antimicrobial Antibody Signatures of IBD
The incidence of inflammatory bowel disease (IBD), which includes Chron’s disease (CD) and ulcerative colitis (UC), is increasing globally, as is the healthcare burden, with studies showing it as one of the top 5 most expensive GI conditions. Early and accurate diagnosis is strongly associated with better patient outcomes. However, the common...
Published: 8/27/2025   |   Inventor(s): Mahasish Shome, Lusheng Song, Yunro Chung, Jonathan Leighton, Joshua LaBaer, Ji Qiu
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Antibody based reagents that specifically recognize toxic oligomeric forms of beta-amyloid
Neurodegenerative diseases such as Alzheimer’s are affecting an increasing number, with annual new diagnoses approaching one-half million; and total cost, $150 billion. Early diagnosis and treatment are important for optimal outcomes, yet there is currently no test to detect such diseases in their early, asymptomatic stages. Active immuniza-tion...
Published: 8/27/2025   |   Inventor(s): Michael Sierks, Srinath Kasturirangan
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Compounds to Modulate Retinoid X Receptors
The human retinoid X receptors (RXRs) function as transcriptional regulators, often in partnership with members of a larger nuclear receptor family of transcription factors. RXR agonists have been shown to modulate RXR transcription and activate or repress various biological pathways and effect therapeutic results for various conditions. There are a...
Published: 8/27/2025   |   Inventor(s): Carl Wagner, Peter Jurutka, Pamela Marshall, Arjan Van Der Vaart
Keywords(s): Bio-Technology, Drug Screening
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Pharmaceuticals, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics
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