Search Results - life+science+(all+ls+techs)

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Intracellular DNA Barcoding Method for Single-Cell Amplification and Sequencing
Studying single cells is difficult due to the laborious and costly cell isolation procedures which restrict throughput and impede the analysis of large numbers of cells or multiple samples in a single experiment. ASU researchers previously developed a method which used the cell’s membrane as a container for different reactions. One such reaction...
Published: 8/19/2025   |   Inventor(s): Kerry Geiler-Samerotte, Kara Schmidlin, Leandra Brettner, Parker Crossland
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Massively Parallel Method to Quantify Protein Folding & Stability
Protein misfolding plays a role in degenerative diseases, cancer evolution, synthetic biology, bioproducts, and more. Despite its importance in all of these fields, researchers often struggle to understand even the basic mechanisms of protein misfolding. For example, there is no tool to determine how much misfolding is happening inside of any given...
Published: 8/19/2025   |   Inventor(s): Yuichi Eguchi, Kerry Geiler-Samerotte
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors
Chimeric Antigen Receptor Therapy Targeting Misfolded Proteins for Neurodegenerative Disease Treatment
In Alzheimer's disease and related dementias (ADRD), cells in the brain generate more misfolded/toxic protein variants than they can clear. The resultant toxic protein variants can kill neurons, and depending on which protein variants and which brain regions, can lead to AD or other ADRDs, or combinations of these diseases. There have been a significant...
Published: 8/15/2025   |   Inventor(s): Michael Sierks
Keywords(s):  
Category(s): Allogenic Cell Therapy, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Pharmaceuticals
Rapid Culture-Free Large-Volume Scattering Imaging for UTI Pathogen Detection and Antibiotic Susceptibility Testing
Antibiotic resistance is a significant public health threat, in part due to the misuse and overuse of broad-spectrum antibiotics. Most antimicrobial susceptibility testing (AST) techniques are slow and culture-based, taking days to produce results, which delays treatment and can put patients at risk. Dipstick-type tests and manual microscopy are faster,...
Published: 8/5/2025   |   Inventor(s): Shaopeng Wang, Brandyn Braswell, Jiapei Jiang
Keywords(s):  
Category(s): Diagnostic Assays/Devices, Artificial Intelligence/Machine Learning, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Imaging
Robotic 3D Guidance and Placement of MIS Tools in the Brain
There are numerous neurological disorders which involve the mesial temporal lobe structures of the brain, such as the hippocampus, amygdala and entorhinal cortex, but may not be adequately treated with pharmaceuticals. Minimally invasive surgical (MIS) techniques may offer a better option for treating these disorders, however, implanting or placement...
Published: 7/26/2025   |   Inventor(s): Hamidreza Marvi, Morteza Varzaghan, Andrew Yang, Tao Zhang
Keywords(s):  
Category(s): Life Science (All LS Techs), Medical Devices
Innovative Multifunctional Edible Coating for Enhancing Fresh Produce
Fresh fruits and vegetables (FVs) can cause foodborne diseases as they are able to harbor a variety of human pathogens and parasites. The short shelf life of fresh produce, due in large part to microbial induced spoilage, is a serious problem that costs the food industry billions a year. Further, nutrients, polyphenols and other bioactive compounds...
Published: 7/16/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Agriculture/Animal Health, Life Science (All LS Techs)
Novel SDS-PAGE Sample Loading Buffer
SDS-PAGE is a ubiquitous analytical technique for separating proteins based on molecular weight. Existing loading buffers used in SDS-PAGE and other protein analyses techniques have difficulty in effectively solubilizing and stabilizing hydrophobic or lipidated proteins, particularly membrane proteins. These proteins tend to aggregate or precipitate...
Published: 6/28/2025   |   Inventor(s): Debra Hansen, Petra Fromme, Jeyatharshika Antonyrajah
Keywords(s):  
Category(s): Imaging, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Photoacoustic Nanosensor Probes for Imaging Neurotransmitter Dynamics
The ability to monitor spatiotemporal dynamics of neurotransmitter release is crucial for understanding the basis of brain function. The precise cognitive operations supported by the changes in cortical neuromodulatory activity have not been fully recognized, largely due to the limitations of current methods which have trade-offs between spatial, temporal,...
Published: 6/28/2025   |   Inventor(s): Heather Clark
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biological Nanotechnology, Life Science (All LS Techs), Imaging, Medical Devices, Medical Imaging
Plasmonic Cell Force Microscopy
Cellular force is important in activities including migration, proliferation and differentiation, which are mediated by interactions between the cell and the ECM. Monitoring these interactions helps to understand how and when mechanical cues play a role in cellular events and underlying mechanisms. However, there are limitations in spatial and temporal...
Published: 6/24/2025   |   Inventor(s): Shaopeng Wang, Xinyu Zhou, Ryan Porter
Keywords(s):  
Category(s): Imaging, Life Science (All LS Techs), Medical Imaging
Nucleic Acid-Triggered Gated Pore Formation for Sensing and Signal Amplification
Cells have developed various means for transporting molecules across membranes as well as cellular compartments separated by membranes. Channels and pores can be formed with different protein assemblies to enable the regulated passage of molecules in and out of cells, which has led to them being exploited as molecular sensors for characterizing biomolecules...
Published: 6/23/2025   |   Inventor(s): Rizal Hariadi, Ranjan Sasmal
Keywords(s):  
Category(s): Biological Nanotechnology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices
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