Search Results - juncheng+(luke)+lu

19 Results Sort By:
Enhancing Fairness Through Aleatoric Uncertainty
Background In recent years, advancements in machine learning have revolutionized various domains, but concerns about bias and unfairness in automated decision-making systems have gained significant attention. One of the causes of unfairness in AI systems is the reliance on training data. Aleatoric uncertainty refers to the inherent randomness or variability...
Published: 8/7/2024   |   Inventor(s): Anique Tahir, Lu Cheng, Huan Liu
Keywords(s): Artificial Intelligence, Machine Learning
Category(s): Physical Science, Computing & Information Technology, Intelligence & Security
Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design. Problem: Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 7/23/2024   |   Inventor(s): Virgil Percec, Drew Weissman, Juncheng (Luke) Lu, Elena Atochina-Vasserman, Devendra Maurya, Dipankar Sahoo
Keywords(s): Drug Delivery, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Vaccines
Discovering Permanent Fluidic Magnets for Liquid Bioelectronics (Case No. 2024-083)
Summary: UCLA researchers from the Department of Bioengineering have developed a permanent fluidic magnet that maintains stable colloids for application in a variety of fields, including physiological monitoring and bioelectronics. Background: Colloid suspensions are comprised of dispersed small solid particles in fluids. The stability of a colloid...
Published: 9/10/2024   |   Inventor(s): Jun Chen
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Mems, Materials > Nanotechnology, Platforms, Platforms > Drug Delivery
Speaking Without Vocal Folds Using Machine-Learning-Assisted Wearable Sensing-Actuation Systems (Case No. 2024-087)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel, machine learning-assisted wearable loudspeaker to capture and translate muscle movement into audible speech. Background: Dysphonia, or the impairment of voice production, is commonly caused by disorders of the vocal folds or postoperative recovery of laryngeal...
Published: 6/27/2024   |   Inventor(s): Jun Chen
Keywords(s):  
Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems
A Wearable On-Eyelid Sensor Network for Vestibular-Ocular Reflex Assessment (Case No. 2023-166)
Summary: UCLA researchers in the Department of Bioengineering have developed an ultra-thin, self-powered, waterproof, biocompatible, and sensitive on-eyelid sensor network for wireless eye movement detection, enhancing vestibular diagnostics. Background: The human balance system relies on the interaction of the vestibular system with the visual and...
Published: 4/19/2024   |   Inventor(s): Jun Chen, Jing Xu
Keywords(s): diseases of the eye, eye motion, eye movement disorders, eye tracking, gaze fixation, magnetoelastic effect, magnetoelastic sensor, on-eyelid sensor, peripheral vestibular disorders, vestibular pathology assessment, Vestibular-Ocular Reflex (VOR)
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics, Electrical, Electrical > Signal Processing, Electrical > Sensors
Reducing Oxidative Stress with Multifunctional Radical Quenchers
Mitochondria are intracellular organelles responsible for a number of metabolic transformations and regulatory functions. They produce much of the ATP employed by eukaryotic cells. They are also the major source of free radicals and reactive oxygen species that cause oxidative stress. Mitochondrial defects are damaging, particularly to neural and...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Jeffrey Armstrong, Omar Khdour, Jun Lu, Pablo Arce
Keywords(s): Therapeutics
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 8/17/2023   |   Inventor(s): Ada Poon, Cheng Chen, Joonseok Yang, Hui Wang
Keywords(s): EEG, Neurology, Wearable
Category(s): Technology Classifications > Engineering
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
2022-276 A Self-Powered Bioelectronic Stent Sensor for Postoperative Blood Flow Rate Monitoring
­Summary: UCLA researchers in the Department of Bioengineering have developed a miniaturized bioelectronic stent sensor that provides continuous, real-time, and reliable hemodynamic monitoring. Background: Diseases caused by arterial atherosclerosis are the leading cause of death and disability in the United States, affecting over 4.6 million...
Published: 9/11/2024   |   Inventor(s): Jun Chen, Geoffrey Colby, Guorui Chen
Keywords(s): Atherosclerosis, Biomaterial 3D Printing, Biomedical Engineering, Cardiovascular, Cardiovascular Disease, Heart Rate , Medical Device, Medical Devices and Materials, Medical Physics , Nanotechnology, Sensors, Smart medical device, Stent, wearable medical device
Category(s): Mechanical, Materials, Materials > Functional Materials, Materials > Nanotechnology, Medical Devices, Electrical > Mems
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
1 2