Search Results - irvin+s.y.+chen

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A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

2018-856 AN APPROACH FOR TARGETED CONDITIONING FOR T CELL TRANSPLANTS

UCLA researchers in the Departments of Microbiology, Immunology, and Molecular Genetics have identified a pre-conditioning reagent for Adoptive Cell Transfer (ACT). The identified reagent specifically ablates T-cells making room for infused cells to engraft and has negligible toxicities compared to traditional conditioning therapies that affect all...

Published: 9/5/2023 | Inventor(s): Irvin S.Y. Chen, Sanggu Kim, Masakazu Kamata, Gajendra Suryawanshi, Robert Donahue

Keywords(s): Immunotherapy, Therapeutics & Vaccines

Category(s): Therapeutics > Immunology And Immunotherapy

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage

2018-749 A METHOD TO DISTINGUISH DIFFERENT RETROVIRAL VECTORS DURING INTEGRATION SITE ANALYSIS

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel gene therapy vector identifying method, capable of screening toxicities of combination therapies.TITLE: A Method to Distinguish Different Retroviral Vectors During Integration Site Analysis BACKGROUND: Many diseases originate from defective...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Gajendra Suryawanshi, Sanggu Kim

Keywords(s): Gene Editing Systems, Gene Therapy, Life Science Research Tools, Plasmids / Vectors, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Plasmids/Vectors, Therapeutics, Therapeutics > Gene Therapy And Editing

2016-255 Method to Enrich for Cells Transduced with Chimeric Antigen Receptors for Gene Therapy (2016-051 rolled in)

Method to Enrich for Cells Transduced with Chimeric Antigen ReceptorsSUMMARYResearchers at UCLA have developed a method to expand chimeric antigen receptor-transduced T cells for use in immunotherapies.BACKGROUNDChimeric Antigen Receptors (CAR) T cells are promising therapeutics for the treatment of cancer and are also being considered for the treatment...

Published: 2/14/2024 | Inventor(s): Otto Yang, Jerome Zack, Scott Kitchen, Ayub Ali, Hwee Ng, Irvin S.Y. Chen

Keywords(s): Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy

2010-709 VIRAL EXPRESSION VECTOR Targeting HIV-1

SummaryUCLA researchers from the Department of Microbiology, Immunology, & Molecular Genetics have developed a viral expression vector that combines two reagents effective against HIV-1 infection.BackgroundHighly active antiretroviral therapy (HAART) has decreased the morbidity and mortality of human immune deficiency virus (HIV) in all parts of...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Dong Sung An, Geoff Symonds, Louis Breton, Michelle Millington, Maureen Boyd

Keywords(s): Gene Editing Systems, Gene Therapy, Infectious Diseases, Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Infectious Diseases, Therapeutics > Gene Therapy And Editing

2000-128 TARGETING LENTIVIRAL VECTORS TO SPECIFIC CELLS AND TISSUES

SummaryResearchers in the UCLA Departments of Medicine and Microbiology, Immunology and Molecular Genetics have developed retroviral vectors pseudotyped with a modified Sinbus virus envelope that exhibit reduced tropism and can be used for the targeted transduction of heterologous genes into cells.BackgroundThere have been numerous attempts to develop...

Published: 7/19/2023 | Inventor(s): Irvin S.Y. Chen, Kouki Morizono

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing