Search Results - hening+lin

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A Novel Selective HDAC11 Inhibitor with Broad Anti-Cancer Efficacy

HDAC11 is a Histone Deacetylase (HDAC) enzyme. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent, which is linked to poor prognosis in multiple cancers. This suggests that inhibition of HDAC11 can be used to treat cancers by modulating protein function. No potent and selective inhibitors for...

Published: 2/2/2026 | Inventor(s): Edward Seto, Hening Lin

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules

Transgenic Mouse Model for Marfan Syndrome Research

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...

Published: 12/23/2025 | Inventor(s): Li Li, Shichao Wu, Jiawei Zhao

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic

Ultrafast Thin-Film Vapor Deposition Technique

Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...

Published: 11/18/2025 | Inventor(s): Feng Yan, Lin Li

Keywords(s):

Category(s): Semiconductors, Materials & Processes, Microelectronics, Physical Science, Semiconductor Devices, Manufacturing/Construction/Mechanical

Novel Kinase Inhibitory Thiazines

Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...

Published: 10/28/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Reverse Thiazine Kinase Inhibitors

Published: 10/28/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Novel Kinase Inhibitory Aplithianines

Published: 10/28/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors

Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...

Published: 1/9/2026 | Inventor(s): Michael Keidar, Li Lin, Vikas Soni, Xiaoliang Yao, Dayun Yan, Jonathan Sherman

Keywords(s):

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Surgical

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 1/9/2026 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

Cold atmospheric plasma-stimulated media for treating cancers

For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...

Published: 1/9/2026 | Inventor(s): Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics

Room-Temperature Copper Alloy Ink for Flexible and Wearable Electronics

This invention presents an air stable copper alloy conductive ink that can be printed and sintered at or near room temperature while achieving high conductivity. Its oxidation resistant alloy design and compatibility with heat sensitive substrates enable low cost, flexible, and sustainable electronic manufacturing for wearable devices and printed circuits. Background:...

Published: 11/14/2025 | Inventor(s): Chuan Jian Zhong, Shan Yan, Ning He

Keywords(s): #SUNYresearch, CleanTech, Technologies, XCEED

Category(s): Technology Classifications > Clean Energy, Technology Classifications > Electronics, Campus > Binghamton University

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