Search Results - edward+seto

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A Novel Selective HDAC11 Inhibitor with Broad Anti-Cancer Efficacy
HDAC11 is a Histone Deacetylase (HDAC) enzyme. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent, which is linked to poor prognosis in multiple cancers. This suggests that inhibition of HDAC11 can be used to treat cancers by modulating protein function. No potent and selective inhibitors for...
Published: 3/13/2025   |   Inventor(s): Edward Seto, Hening Lin
Keywords(s):  
Category(s): Technology Classifications > Therapeutics
A Small Molecule Inhibitor Selective for HDAC11
­HDAC11 is an enzyme which belongs to the Histone Deacetylase (HDAC) class of enzymes. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent. The defatty-acylase activity of HDAC11 is linked to increased interferon I signaling, suggesting that inhibition of HDAC11 can be used to treat diseases...
Published: 2/18/2025   |   Inventor(s): Edward Seto, Hening Lin, Thanh Ho
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules