Search Results - ning+he

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Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 3/4/2025 | Inventor(s): Yong Zeng, He Yan

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

Repurposing H1 and H2 antihistamines for the treatment of erythropoietic protoporphyria

Invention Summary: Erythropoietic protoporphyria (EPP) is a severe genetic disorder caused by defects in heme biosynthesis, leading to the accumulation of protoporphyrin IX (PP-IX) in the liver. This accumulation results in cholestasis and, in the most severe cases, end-stage liver failure, necessitating liver transplantation or leading to...

Published: 2/4/2025 | Inventor(s): Bishr Omary, Ning Kuo

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Rare Disease

Novel Kinase Inhibitory Thiazines

Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...

Published: 3/14/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Reverse Thiazine Kinase Inhibitors

Published: 3/14/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Novel Kinase Inhibitory Aplithianines

Published: 3/14/2025 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases

Identification of a Novel Parvovirus for Vaccine Development and Use as a Diagnostic Tool

This technology includes a procedure for novel virus identification in a variety of human specimens by solexa high-throughput sequencing, which allows for the screening a large number of clinical specimens for novel virus discovery in a highly efficient and relatively economical method. By using this technique, we have successfully identified a novel...

Published: 9/5/2024 | Inventor(s): Ning Zhi, Neal Young, Baoyan Xu, Keji Zhao, Gangqing Hu

Keywords(s):

Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

Micro-Trenches That Retain Trapped Gas Under High-Speed Water Flows (UCLA Case No. 2023-204)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a design of microstructured surfaces capable of retaining air pockets under water at flow speeds above 10 knots so that watercraft can travel with a reduced drag. Background: A major challenge limiting efficiency and speed of watercraft is the friction...

Published: 2/14/2025 | Inventor(s): CJ Kim, Ning Yu

Keywords(s): boats, Drag (Physics), drag reduction, fluid mechanics, friction reduction, fuel efficiency, hull, Hydrophobic, liquid-air interface, marine applications, maritime, microtrenches, navy, planing hull, Seawater, ships, Superhydrophobic, water sports, watercraft

Category(s): Mechanical, Materials

Parvovirus B19 Vaccine

Parvovirus B19 (B19V) infection causes fifth disease, a disease characterized by rashes to the face and other parts of the body that primarily affects children. However, adults can also develop fifth disease and it can lead to more severe conditions. Patients that are immunocompromised, such as those who are HIV infected, organ transplant recipients,...

Published: 10/28/2024 | Inventor(s): Neal Young, Sachiko Kajigaya, Takashi Shimada, Ning Zhi

Keywords(s): Admin Lic Spec Review Mar-09 Active Determina, AgainstB19V, B19, B19V, BBXXXX, CAPSID, Capsids, CODON, CRADA, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, diagnostic, DNA-based, DXXXXX, GENES, Infection, Non-pennissive, PARTICLE, PARVOVIRUS, Patent Category - Biotechnology, SACGHS DNA Patent Initial Set, UA1XXX, VACCCINE, vaccines, VIRUS-LIKE, VLP-and

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, TherapeuticArea > Rare/Neglected Diseases

Parvovirus B19 Codon Optimized Structural Proteins for Vaccine and Diagnostic Applications

Parvovirus B19 (B19V) is the only known pathogenic human parvovirus. Infection by this viral pathogen can cause transient aplastic crisis in individuals with high red cell turnover, pure red cell aplasia in immunosuppressed patients, and hydrops fetalis during pregnancy. In children, B19V most commonly causes erythema infectiosum, or fifth's disease....

Published: 10/28/2024 | Inventor(s): Neal Young, Sachiko Kajigaya, Ning Zhi

Keywords(s): Against, AgainstB19V, APPLICATION, B19V, BBXXXX, CAPSID, Cells, CODON, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPING, DNA-based, DXXXXX, Erythema infectiosum, Fifth Disease, GENES, Human parvovirus B19 infection, Hydrops fetalis, Infection, Non-pennissive, OPTIMIZED, PARTICLE, Parvovirus antenatal infection, Patent Category - Biotechnology, Pure red cell aplasia, USAGE, vaccines, VIRUS-LIKE, VLP-and

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, Application > Diagnostics, TherapeuticArea > Infectious Disease

Erythroid Progenitor Cell Line for Hematological Disease Applications

Plasmodium vivax (malaria) is a significant health concern in many parts of Asia, Latin America, North Africa, and the Middle East. There is a lack of continuous culture systems for this pathogen. The subject technology is an erythroid progenitor continuous cell line (termed CD36E) identified by erythroid markers CD36, CD33, CD44, CD71, CD235, and...

Published: 10/28/2024 | Inventor(s): Ning Zhi, Neal Young, Susan Wong

Keywords(s): &, Blod, Blood, CD36E, Cell, Cells, continuous, DDXXXX, DISEASES, DXXXXX, Erythroid, Involving, Line, Malaria, Malaria (Plasmodium sp.), Patent Category - Biotechnology, PLASMODIUM, Potential, PRECURSORS, Progenitor, RED, Spp., STUDIES, termed, USES

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, TherapeuticArea > Infectious Disease

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