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Search Results - dongfang+liu
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CAR-NK based combinatorial treatment for drug-resistant tumors
Incucyte Killing Assay Images with AnnexinV cell death signal in MKI-Resistant HCC (Top panel). Chromium-51 release assays comparing GRP78 CAR-NK Killing to Naïve NK killing of various MKI-resistant tumor cell lines (bottom panels). Values shown are Means ± SEM. Significant p values indicated in red. Invention Summary: CAR-NK...
Published: 8/19/2024
|
Inventor(s):
Dongfang Liu
,
Youssef Sabha
,
Chih-Hsiung Chen
Keywords(s):
Anti-cancer
Category(s):
Technology Classifications > Cell Therapy
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024
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Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
Peptide Mimetic Ligands of Polo-like Kinase 1 Polo Box Domain (“Plk1 PBD Portfolio”)
Abstract: Polo-like kinase 1 (Plk1) is a critical protein involved in regulation of mitosis, and aberrant expression of this kinase is found in various cancer types. Inhibition of Plk1 is currently being pursued in pre-clinical drug development for novel anti-cancer therapeutics. Plk1 contains an allosteric domain, known as the polo-box domain (PBD),...
Published: 5/22/2024
|
Inventor(s):
Terrence Burke
,
Jung-Eun Park
,
Wen-Jian Qian
,
Fa Liu
,
Kyung Lee
Keywords(s):
Burke
,
CANCER
,
mitosis
,
Peptide Inhibitor
,
polo-box domain (PBD)
,
Polo-like kinase 1 (Plk1)
,
therapeutic
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
Improving Object Detection and Instance Segmentation of Eukaryotic Cells Using Semantic Aware Data Augmentation
Invention Summary: Machine Learning and Artificial Intelligence (AI)-Driven analysis have provided great advancements in microscopic imaging in the Biomedical field. The efficacy of many of these systems relies on the availability of many well-defined and empirically annotated images to serve as training data to teach such advanced...
Published: 5/15/2024
|
Inventor(s):
Dongfang Liu
,
Alireza Naghizadeh
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Software & Algorithms
DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 10/29/2024
|
Inventor(s):
Dongfang Liu
,
Xuening Wang
,
Jacques Roberge
Keywords(s):
Anti-cancer
,
Proteins
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Cancer
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control. Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 10/21/2024
|
Inventor(s):
Dongfang Liu
,
Minh Ma
,
Saiaditya Badeti
Keywords(s):
Antiviral
,
Bioengineering scaffolds
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
,
Technology Classifications > COVID-19
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
|
Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
JobViz: User Interface for Visualization of Majors & Jobs
Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...
Published: 9/8/2022
|
Inventor(s):
Deborah Silver
,
Li Liu
Keywords(s):
Category(s):
Technology Classifications > Software & Copyright
,
Technology Classifications > Software & Algorithms
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control. Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 10/21/2024
|
Inventor(s):
Dongfang Liu
,
Minh Ma
,
Saiaditya Badeti
Keywords(s):
Antiviral
,
Bioengineering scaffolds
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > COVID-19
,
Technology Classifications > Therapeutics
,
Technology Classifications > Cell Therapy
Monolithic White and Multi-Color Lasers Tunable in Full Visible Spectrum
Semiconductor lasers able to emit over the full visible color spectrum have a wide range of practical applications such as solid-state lighting, full-color displays, visible color communications, and multi-color fluorescence sensing. To the human eye, light with a mixture of four monochromatic lasers is visually equivalent to a white illuminant. Current...
Published: 2/23/2023
|
Inventor(s):
Cun-Zheng Ning
,
Sunay Turkdogan
,
Zhicheng Liu
,
Fan Fan
Keywords(s):
Materials and Electronics
Category(s):
Advanced Materials/Nanotechnology
,
Chemical/Biological Sensors
,
Energy & Power
,
Imaging
,
Medical Imaging
,
Physical Science
,
Physics
,
Proteomic Assays/Reagents/Tools
,
Semiconductor Devices
,
Semiconductors, Materials & Processes
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