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A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes
Abstract: Currently, there is no other whole-animal reporter for epigenetic regulation established in any vertebrate. The inventors generated this novel zebrafish line using a transgene construct containing dazl gene silencing sequences (CpG island) fused to a destabilized GFPd2 gene driven by the ubiquitously expressing ef1alpha promoter. The resulting...
Published: 4/8/2024
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Inventor(s):
Aniket Gore
,
Brant
Weinstein
Keywords(s):
Development
,
DNA Methylation
,
Epigenetic Silencing
,
Eunice Kennedy Shriver National Institute of Child Health an
,
GFPd2
,
NICHD
,
Tissue-specific Expression
,
Weinstein
,
Zebrafish
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
TherapeuticArea > Oncology