Search Results - zebrafish

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A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes
Abstract: Currently, there is no other whole-animal reporter for epigenetic regulation established in any vertebrate.  The inventors generated this novel zebrafish line using a transgene construct containing dazl gene silencing sequences (CpG island) fused to a destabilized GFPd2 gene driven by the ubiquitously expressing ef1alpha promoter. The resulting...
Published: 4/8/2024   |   Inventor(s): Aniket Gore, Brant Weinstein
Keywords(s): Development, DNA Methylation, Epigenetic Silencing, Eunice Kennedy Shriver National Institute of Child Health an, GFPd2, NICHD, Tissue-specific Expression, Weinstein, Zebrafish
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation
HEADLINE: Novel protein induces pancreatic beta cell proliferation, is ideal for diabetes treatment research Our scientists discovered a novel protein that offers a potential new avenue of research for labs developing drugs to treat diabetes. The newly-discovered BefA (β Cell Expansion Factor A) protein acts to increase total pancreatic...
Published: 10/19/2023   |   Inventor(s): Karen Guillemin, Jennifer Hampton
Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish
Category(s): Diagnostics, Therapeutics, Research Tools
Development of a Novel Zebrafish Screening System and Identification of a Novel Protein with Anti-Inflammatory Activity
HEADLINE: Novel protein with strong anti-inflammatory activity has been shown to effectively treat inflammatory bowel disease and prevent septic shock in zebrafish. University of Oregon scientists have discovered a novel protein with strong anti-inflammatory activity. The novel protein has been shown to effectively treat inflammatory bowel...
Published: 11/4/2024   |   Inventor(s): Karen Guillemin, Annah Rolig
Keywords(s): Biochemistry, Biological Materials, Biotech, Research Tools, Therapeutics, Zebrafish
Category(s): Research Tools, Therapeutics, Agricultural, Diagnostics