Search Results - zebrafish

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A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes
Abstract: Currently, there is no other whole-animal reporter for epigenetic regulation established in any vertebrate.  The inventors generated this novel zebrafish line using a transgene construct containing dazl gene silencing sequences (CpG island) fused to a destabilized GFPd2 gene driven by the ubiquitously expressing ef1alpha promoter. The resulting...
Published: 4/22/2025   |   Inventor(s): Aniket Gore, Brant Weinstein
Keywords(s): Development, DNA Methylation, Epigenetic Silencing, Eunice Kennedy Shriver National Institute of Child Health an, GFPd2, NICHD, Tissue-specific Expression, Weinstein, Zebrafish
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Development of a Novel Zebrafish Screening System and Identification of a Novel Protein That Induces Pancreatic Beta-Cell Proliferation
This invention enables a novel, microbiome-derived approach to diabetes treatment by leveraging a protein from the gut bacterium Aeromonas that increases pancreatic β cell number through enhanced proliferation, differentiation, and survival. By targeting restoration of insulin-producing β cells, the technology addresses a core unmet need in...
Published: 1/6/2026   |   Inventor(s): Karen Guillemin, Jennifer Hampton
Keywords(s): Biochemistry, Biological Materials, Biotech, Therapeutics, Zebrafish
Category(s): Diagnostics, Therapeutics, Research Tools