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Atomically Precise Semiconductor Nanoclusters With Synthetically Controlled Properties

Applies Cation Exchange Reaction to Synthesize Metal Chalcogenides at the Nanometer Scale with Atomic Precision These one-nanometer-scale semiconductor clusters have special electronic and optical properties, making them useful for advanced applications such as light-emitting diodes (LEDs). While scientists can confidently form nanometer scale clusters...

Published: 12/23/2024 | Inventor(s): Chenjie Zeng, Fuyan Ma

Keywords(s):

Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Others > Cleantech

S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use

Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Oncology, Therapeutics

LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

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Category(s): Neurology/Neurosurgery, Therapeutics

An Insertable Glucose Sensor Using a Compact and Cost-Effective Phosphorescence Lifetime Imager and Machine Learning (Case No. 2024-260)

Summary: UCLA researchers in the Department of Electrical & Computer Engineering have developed a new phosphorescence lifetime imaging (PLI) and deep learning based continuous glucose monitoring platform with improved accuracy. Background: Glucose is a biomarker for diabetes, a chronic disease that affects over 450 million people globally....

Published: 10/22/2024 | Inventor(s): Aydogan Ozcan, Zoltan Gorocs, Artem Goncharov, Ridhi Pradhan, Brian Ko, Michael McShane

Keywords(s): Blood Glucose Monitoring, chronic diabetes management, continuous glucose monitoring (CGM), diabetes and obesity, diabetes management and monitoring, disease multiplexing, Glucose, glucose intolerance, insulin pump, type 1 and 2 diabetes

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Hospital Systems, Electrical, Electrical > Sensors

Steric Hindrance Effect of Additives for Tuning the Perovskite Crystal Orientation (Case No. 2024-023)

Summary: UCLA Researchers in the Department of Materials Science and Engineering have developed a method to tune perovskite crystal orientation for increased performance, energy efficiency, and reduced material defect with a variety of field applications, including solar cells and LEDs. Background: Perovskite holds considerable promise as a highly...

Published: 10/25/2024 | Inventor(s): Yang Yang, Chunqing Ma, Haoxiang Duan, Dong Meng

Keywords(s): Energy Efficiency, energy-efficient, Imaging, Liquid-Crystal Display, Nanocrystal, OLED, Optoelectronics, organic photo detector, organic photovoltaics, perovskite, perovskite devices, perovskite solar cell, photodetection, Solar Cell, X-ray detectors

Category(s): Chemical > Chemical Processing & Manufacturing, Energy & Environment > Energy Efficiency, Energy & Environment, Materials > Composite Materials, Optics & Photonics, Optics & Photonics > Fiber Optics, Materials > Functional Materials

Affinity measurement and sequencing of T cell receptor

The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...

Published: 9/13/2024 | Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He

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Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform

Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer

Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...

Published: 9/18/2024 | Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji

Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

Comprehensive and Individualized Menopause Care Delivery Protocol With Technological Decision Support Aid (Case No. 2024-193)

Summary: Researchers in the UCLA Department of Obstetrics and Gynecology have developed a new clinical decision support system for improved menopause care. Background: Each year, approximately 1.3 million women in the United States enter menopause. This is often accompanied by symptoms such as hot flashes, mood changes, and sleep issues. In addition,...

Published: 10/2/2024 | Inventor(s): Rajita Patil, Erica Oberman, Brittany Davis, Rhonda Voskuhl, Kathleen Van Dyk, Ravi Aysola, Louise Dixon De Silva, Karol Watson, Lua Jafari, Julie Bernthal, Rashmi Mullur, Albert Shieh, Elizabeth Ko, Katie Hu, Aashini Master, Kelly Mccann, Kelsey Collins, Katherine Unverferth, Tamara Grisales, Amy Rosenman, Andrea Rapkin

Keywords(s): clinical care methodology, clinical decision support, EHR, EHR integration, electronic health records (EHR), FemTech, femtech medical device, lab results analysis, medical bias reduction, Menopause, menopause management, patient questionnaire, period, personalized medicine, predictive analytics, specialist referral, women’s health

Category(s): Software & Algorithms, Software & Algorithms > Programs, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices, Medical Devices > FemTech

High-throughput sequencing technology for T-cell receptor specificity

TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...

Published: 8/7/2024 | Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Chenfeng He, Keyue Ma

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology

ARPLA: a revolutionary glycoRNA imaging tool with precision and power

Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...

Published: 7/26/2024 | Inventor(s): Yi Lu, Yuan Ma, Weijie Guo, Quanbing Mou

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform

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