Search Results - can+korman

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NPEPPS Enhancers for Treating Tau-Induced Neurodegeneration (UCLA Case No. 2018-161)
UCLA researchers from the Department of Neurology have developed first-in-class small-molecule activators of NPEPPS that effectively lower pathological tau, offering a novel disease-modifying strategy for Alzheimer’s and other neurodegenerative disorders. BACKGROUND: Neurodegenerative dementias such as Alzheimer’s Disease (AD) and progressive...
Published: 10/22/2025   |   Inventor(s): Daniel Geschwind, Robert Damoiseaux, Liting Deng, Michael Jung, Jennifer Murphy, Gaoyuan Ma
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Diagnostic Markers > Targets And Assays
Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
Rapid 3D Printing of Aerogels with Bioinspired Surface Structures for Solar Steam Generation
Invention Description Freshwater scarcity is a critical global challenge. Desalination and water purification, particularly through solar steam generation, offer promising solutions by converting seawater and polluted water into freshwater using solar energy. Aerogels doped with reduced graphene oxide (rGO) enhance this process by improving water transport...
Published: 9/24/2025   |   Inventor(s): Xiangfan Chen, Luyang Liu, Chao Ma
Keywords(s): Additive Manufacturing, Advanced manufacturing, Bio Inspired Design, Materials, water processing, Water Purification
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Environmental, Environmental Remediation/Wastewater Treatment, Physical Science
Reliable Liquid Metal Composites for Soft Robotics, Electronics, and Thermal Management
This invention introduces oxide-flake-stabilized liquid metal powders that suppress supercooling, enabling reliable phase transitions for tunable stiffness, thermal management, and adaptive devices. Background: Liquid metal (LM)-based composites are promising for tunable stiffness, shape memory, and thermal management applications in robotics, electronics,...
Published: 9/24/2025   |   Inventor(s): Pu Zhang, Jiexian Ma
Keywords(s): CleanTech
Category(s): Campus > Binghamton University, Technology Classifications > Engineering
LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles
Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies. Problem: Chimeric antigen receptor (CAR)-T cell therapy has transformed cancer treatment by engineering patients' T cells to precisely target and eradicate cancer cells....
Published: 8/28/2025   |   Inventor(s): Jina Ko, Jianhua Lim
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Ampule-Based Synthesis of Sulfur-Porous Carbon Composites for Lithium-Sulfur Batteries
Background Lithium/sulfur (Li/S) batteries are garnering significant attention as a promising solution for next-generation electrochemical energy storage. Their potential to revolutionize the battery industry stems from several key advantages that address the limitations of current lithium-ion (Li-ion) technology. These advantages include an exceptionally...
Published: 10/30/2025   |   Inventor(s): Yoon Hwa, David Wright, Yuhui An
Keywords(s): Chemicals, Energy storage, Engineering, Materials, Nanomaterials, Synthesis
Category(s): Energy & Power, Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes
A conserved viral peptide for use in cancer immunotherapy
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for viral peptide (CE1)-based therapeutics for HCC prevention and treatment. Description of Technology: Hepatocellular carcinoma (HCC) is a common and aggressive primary liver cancer. It develops mainly from at-risk individuals with underlying chronic...
Published: 10/8/2025   |   Inventor(s): Xin Wei Wang, Lichun Ma, Man Hsin Hung
Keywords(s):  
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
A novel approach to the treatment of EGFR mutant non-small cell lung cancer (NSCLC)
Background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for ~85% of all lung cancer cases. NSCLC is slow growing and often diagnosed at later stages when it has already spread, making treatment difficult. Resistance to therapy is a major challenge in effectively treating patients with NSCLC. 10-30% of...
Published: 8/14/2025   |   Inventor(s): Jack Elias, Suchitra Kamle, Chun Geun Lee, Bing Ma
Keywords(s):  
Category(s): Oncology
Functional Hierarchical Porous Organic Polymers for Water Purification
Advantages: High absorption capacity Fast and controllable kinetics Facile regeneration and recyclability Stable under a wide range of conditions High density of chelating sites Summary: Water and energy purification are important factors in minimizing the harsh impact of technology on the environment. Coal-powered fuel stations and waste...
Published: 3/4/2025   |   Inventor(s): Shengqian Ma, Qi Sun, Briana Aguila
Keywords(s):  
Category(s): Technology Classifications > Energy & Environment
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