Search Results - can+korman

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Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
Published: 9/13/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer
Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024   |   Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji
Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics
Comprehensive and Individualized Menopause Care Delivery Protocol With Technological Decision Support Aid (Case No. 2024-193)
Summary: Researchers in the UCLA Department of Obstetrics and Gynecology have developed a new clinical decision support system for improved menopause care. Background: Each year, approximately 1.3 million women in the United States enter menopause. This is often accompanied by symptoms such as hot flashes, mood changes, and sleep issues. In addition,...
Published: 9/3/2024   |   Inventor(s): Rajita Patil, Erica Oberman, Brittany Davis, Rhonda Voskuhl, Kathleen Van Dyk, Ravi Aysola, Louise Dixon De Silva, Karol Watson, Lua Jafari, Julie Bernthal, Rashmi Mullur, Albert Shieh, Elizabeth Ko, Katie Hu, Aashini Master, Kelly Mccann, Kelsey Collins, Katherine Unverferth, Tamara Grisales, Amy Rosenman, Andrea Rapkin
Keywords(s): clinical care methodology, clinical decision support, EHR, EHR integration, electronic health records (EHR), FemTech, femtech medical device, lab results analysis, medical bias reduction, Menopause, menopause management, patient questionnaire, period, personalized medicine, predictive analytics, specialist referral, women’s health
Category(s): Software & Algorithms, Software & Algorithms > Programs, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices, Medical Devices > FemTech
High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
Published: 8/7/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Chenfeng He, Keyue Ma
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024   |   Inventor(s): Yi Lu, Yuan Ma, Weijie Guo, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Antibodies against CD5L for therapeutic and diagnostic uses
Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...
Published: 5/28/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Anil Sood
Keywords(s):  
Category(s): Biologics, Oncology, Therapeutics
HydroGEN Forecast Generator
HydroGEN is a web-based platform for hydrologic simulation utilizing advanced machine learning algorithms and current data to provide accurate forecasts to water managers and other decision makers. The HydroGEN Forecast Generator is a workflow that builds a hydrologic model for any watershed in the United States and seasonal runs forecasts using a machine...
Published: 8/23/2024   |   Inventor(s): Laura Condon, Nirav Merchant, Amy Johnson, Reed Maxwell, Peter Melchior, Jill Williams, Will Lytle, Edwin Skidmore, Yueling Ma, Elena Leonarduzzi, Andrew Bennett, Luis De la Fuente
Keywords(s):  
Category(s): Technology Classifications > Energy, Cleantech & Environmental, Technology Classifications > Software & Information Technology, Technology Classifications > Agriculture & Horticulture
Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...
Published: 5/28/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell
Keywords(s):  
Category(s): Diagnostics, Oncology, Therapeutics, Biologics
A Potent Short Hairpin RNA (SHRNA734) to Positively Select and Eliminate Genetically Modified Cells (UCLA Case No. 2016-524)
BACKGROUND: Gene therapy strategies to modify human stem cells hold great promise for curing many human diseases. However, previous clinical studies have met with limited success, largely due to the low engraftment of gene modified stem cells. One strategy to overcome this challenge involves engineering stem cells in which HPRT expression is knocked...
Published: 3/8/2024   |   Inventor(s): Dong Sung An, Saki Shimizu
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Infectious Diseases
Method for Dry Battery Electrode Manufacturing Via Direct Powder Bed Formation and Compression
Background Recent efforts to address climate change and develop a clean-energy economy in the United States have focused on the electrification of the transportation sector. Sustainable battery manufacturing has become a critical part of these efforts, and current manufacturing practices face challenges relating to environmental impact, advancing electrode...
Published: 5/29/2024   |   Inventor(s): Yoon Hwa, Yuhui An
Keywords(s): Battery, Energy storage, Engineering, Manufacturing, Powder
Category(s): Physical Science, Energy & Power, Alternative Energy, Semiconductors, Materials & Processes
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