Search Results - zhiqiang+lin

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Method and device for fabricating waveguides for frequency conversion Institute Reference: 2-23013 Background Optical frequency conversion based upon a quadratic optical nonlinearity is a powerful technology to transfer high-coherence laser radiation into new frequencies. For thin-film lithium-niobate-on-insulators (LNOI’s), the efficiency...

Published: 10/22/2024 | Inventor(s): Qiang Lin, Jingwei Ling, Jeremy Staffa

Keywords(s):

Category(s): Computer Hardware, Optics, Nanotechnology

Microcomb-Based Ising Machine

A microcomb-based Ising machine for ultrafast, scalable computation of NP-hard optimization problems using optical microresonators Institute Reference: 2-23040 Background The exponential growth of computational complexity in solving high-dimensional problems, such as combinatorial optimization, has long exceeded the capabilities of conventional digital...

Published: 10/22/2024 | Inventor(s): Qiang Lin, Michael Huang, Raymond Lopez-Rios

Keywords(s):

Category(s): Computer Hardware, Informatics, Optics

S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use

Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Oncology, Therapeutics

LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics

Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...

Published: 3/24/2025 | Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell

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Category(s): Diagnostics, Oncology, Therapeutics, Biologics

Monoclonal antibodies against human endotrophin for therapeutic and diagnostic use.

Background Studies have shown that endotrophin, the carboxy-terminal cleavage product of the COL6α3 chain, has potent effects on transformed mammary ductal epithelial cells in rodents. It is abundantly expressed in adipose tissue and is a chemoattractant for macrophages, exerts effects on endothelial cells and enhances the progression through...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Philipp Scherer

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier

Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...

Published: 10/21/2024 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Drug Delivery, Therapeutics, Neurology/Neurosurgery, Oncology, Biologics

TREM2 Monoclonal Antibody for Therapeutic and Diagnostic Use

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. Previous studies in rodent models of AD have shown that mice with increased TREM2 expression have reduced amyloid pathology. UTHealth inventors created and...

Published: 10/21/2024 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Therapeutics, Diagnostics, Biologics, Neurology/Neurosurgery

Recovering Critical Elements from Acid Mine Drainage

THE CHALLENGE The demand for certain elements, such as Manganese (Mn), Cobalt (Co), and Nickel (Ni), has surged in recent years due to the rapid growth of battery production for electric vehicles and utility-scale energy storage. The United States government has deemed Co, Ni, and Mn critical elements, primarily because of the country’s high...

Published: 6/26/2024 | Inventor(s): Wencai Zhang, Qi Li, Rick Honaker

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Category(s): Technology Classifications > Energy, Technology Classifications > Mining and Recycling, Technology Classifications, Technology Classifications > Chemicals/Materials

A Novel Carbohydrate Antibody to GalNac1-3Gal and Its Application for Cancer Diagnostic and Prognosis

Abstract: Cervical cancer is one of the most common cancers among women worldwide. Currently, physical descriptors such as tumor size and depth are the primary factors used for deciding the course of treatment. Despite significant efforts to identify prognostic biochemical markers or therapeutic targets to improve diagnosis and treatment, none have...

Published: 4/8/2024 | Inventor(s): Jeffrey Gildersleeve, Zhitao Li, Qian Li, Miriam Anver, Donna Butcher

Keywords(s): ANTIBODY, CERVICAL, GaLNAc1-3Gal, Gildersleeve, Immunohistochemical staining, Larynx, Prognostic marker, SKIN, Squamous Cell

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

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