Search Results - yeast

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A Genetic System in Yeast for Functional Identification of Human p53 Mutations
Mutations in the p53 gene are associated with 50% of all cancers and nearly 80% of the p53 mutations are missense changes. We have developed genetic assays based in yeast that can functionally categorize expressed p53 mutant proteins. The combined assays are referred to as the FIP53 system. Because human p53 cDNA can be conveniently cloned in yeast,...
Published: 10/28/2024   |   Inventor(s): Alberto Inga, Michael Resnick
Keywords(s): CA1XXX, CAXXXX, FUNCTIONAL, GAXXXX, Genetic, Human, Identification, Listed LPM Wong as of 4/15/2015, Mutations, p53, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, System, X, Yeast
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, Application > Therapeutics
Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 3/30/2022   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
Synthetic Lethal Targeting of Mismatch Repair Defective Cells
Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 3/30/2022   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
Production of Biofuels, Biomaterials and Sugar Alcohols (Polyols) by a Recombinant Microorganism Expressing Enzymes (Det1 and Pho13) for NADPH Upregulation and Polyol Phosphatase (Ynl010w) for Polyol Phosphatase Dephosphorylation
A New Enzyme and Process for Metabolic Engineering of Production of Sorbitol, Mannitol, Ribitol, Xylitol, Arabitol, Erythritol, and Other Polyols Princeton Docket # 13-2939 Scientists in the Lewis-Sigler Institute, Princeton University have discovered an enzyme which encodes a broad-spectrum, D-stereoisomer-specific sugar alcohol phosphatase,...
Published: 9/26/2023   |   Inventor(s): Yi-Fan Xu, Joshua Rabinowitz, Fabien Letisse, Sarah Johnson
Keywords(s): biofuels, Biotechnology/Pharmaceuticals, Chemistry, metabolic engineering, model organism, yeast
Category(s): Biotechnology/Pharmaceuticals