Search Results - xiaoyuan+(shawn)+chen

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Scalable, Low Voltage Device For Liquid Crystal-Based Technologies
A multi-stable liquid crystal (LC) device based on saddle-spray director variation that enables fast optoelectronic switching and has low power requirements. Problem: LC devices are crucial for a number of modern technologies including monitors, electronic switches, and storage devices. These devices rely on an optoelectrical process by which applied...
Published: 7/30/2024   |   Inventor(s): Shu Yang, Yu Xia, Timothy Atherton, Douglas Cleaver, Andrew DeBenedictis, DaeSeok Kim
Keywords(s): Optics & Photonics 
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials
PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes
This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy...
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Lixin Lang, Gang NIU
Keywords(s):  
Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology
Radiotherapy and Imaging Agent-based on Peptide Conjugated to Novel Evans Blue Derivatives with Long Half-life and High Accumulation in Target Tissue
This technology includes a newly designed, truncated Evans Blue (EB) form which allows labeling with metal isotopes for nuclear imaging and radiotherapy. Unlike previous designs, this new form of truncated EB confers site specific mono-labeling of desired molecules. The newly designed truncated EB form can be conjugated to various molecules including...
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss
Keywords(s):  
Category(s): ResearchProducts > Research Equipment, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
Evans Blue Modified Small Molecule-based Prostate-specific Membrane Antigen (PSMA) Radiotherapy and Nuclear Imaging
This technology includes anti-PSMA antibody labeled with 177Lu, which has shown to be an effective treatment for prostate cancer. Several small molecules targeting PSMA were also evaluated in prostate cancer patients labeled with betta emitters such as 177Lu. The most common one is 177Lu-PSMA-617 which is under clinical evaluation in many countries....
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Oncology
PRIME: A Personalized Recommendation for Information Visualization Methods via Extended matrix Completion
Information visualization is an important mode of human-computer interaction to acquire insights of complex datasets. However, a uniform visualization format may be inefficient to bring the insights to different users at different contexts due to the users' differences in knowledge, perception, and cognition capabilities. On the other hand, typical...
Published: 10/27/2023   |   Inventor(s): Ran Jin, Chen Xiaoyu, Nathan Lau
Keywords(s):  
Category(s): Technology Classifications > Software, Technology Classifications > Communication
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Evans Blue Dye Derivatives for Serum Albumin Labeling
The invention is an imaging agent and method of use for imaging blood pools and the lymphatic system. The imaging agent binds with high affinity to serum albumin, the most abundant serum protein, and can be tagged with several isotopes making it suitable for magnetic resonance imaging or positron emission tomographic imaging. To date, only very few...
Published: 7/25/2024   |   Inventor(s): Lixin Lang, Gang NIU, Xiaoyuan (Shawn) Chen
Keywords(s): Albumin, BLUE, CA2BXX, Evans Blue, fluorene-18, IA4AXX, LABELED, LABELING, Listed LPM Fenn as of 4/15/2015, Magnetic Resonance, PET, Pet imaging, positron emission, Positron-Emitting, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PXXXXX
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Consumer Products, Application > Diagnostics, Application > Research Materials
Boron Amino Acid Mimetics for PET Imaging of Cancer
Available for licensing and commercial development as imaging agents for positron emission tomography of cancer are boramino acid compounds. The inventors showed that mimetics created by substituting the carboxylate group (-COO-) of an amino acid with trifluoroborate (-BF3-) are metabolically stable and allow for the use of fluorene-18 (18F) as the...
Published: 7/25/2024   |   Inventor(s): Zhibo Liu, Xiaoyuan (Shawn) Chen
Keywords(s): AA3CXX, Boramino, CA1CXX, CA2BXX, CA2CXX, Cancer diagnosis, Cancer diagnostic, fluorene-18, Mimetic, MIMETICS, positron emission, VCXXXX, WBXXXX, WIXXXX, XFXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Medical Devices, Application > Diagnostics, Application > Non-Medical Devices, Application > Software / Apps, TherapeuticArea > Oncology
Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast
The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod...
Published: 7/25/2024   |   Inventor(s): Jinhao Gao, Zhenghuan Zhao, Xiaoyuan (Shawn) Chen
Keywords(s): Agents, CA2CXX, Contrast, High-Performance, IMAGING, IRON, Magnetic, Nanoparticles, Non-spherical, OXIDE, PXXXXX, Resonance, T2, VCXXXX, VDXXXX, WBXXXX, XFXXXX, XGXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices
Ultra-sensitive Diagnostic Detects fg/mL-pg/mL Pathogen/Disease Protein by Visual Color Change
This technology is an ultra-sensitive colorimetric assay, based on an enzyme-catalyzed gold nanoparticle growth process, for detection of disease-associated proteins (biomarkers) and disease diagnosis. Current detection methods, such as ELISA immunoassays, measure concentrations above 0.1 ng/mL in a sample. PCR, although more sensitive than ELISA, requires...
Published: 7/25/2024   |   Inventor(s): Dingbin Liu, Xiaoyuan (Shawn) Chen
Keywords(s): assay, AuNPbased, AuNP-based, Biomarkers, CA1XXX, COLORIMETRIC, DAXXXX, Detection, GOLD, Nanoparticle, Ultrasensitive, VCXXXX, VJXXXX, VLXXXX, WBXXXX, XCXXXX, XDXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Diagnostics, Application > Non-Medical Devices, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology
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