Search Results - xiaoyuan+(shawn)+chen

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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
LORI: Local Low-Rank Imputation for Context-Aware AI
THE CHALLENGE Leveraging Artificial Intelligence (AI) for data-driven decision-making faces a major challenge in automatically configuring and optimizing complex AI pipelines across different use cases. As organizations deal with diverse datasets and fast-changing requirements, selecting the right combination of processing steps becomes increasingly...
Published: 4/16/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Software
Attention-on-Attention for Human-Guided AI
THE CHALLENGE A major challenge facing industries like advanced manufacturing and quality inspection is the gap between human expertise in visual search and the limited capabilities of current AI systems. While skilled inspectors can dynamically scan, interpret, and integrate subtle visual cues over time, most existing automated solutions rely on static...
Published: 4/16/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Communication, Technology Classifications > Software
Scalable, Low Voltage Device For Liquid Crystal-Based Technologies
A multi-stable liquid crystal (LC) device based on saddle-spray director variation that enables fast optoelectronic switching and has low power requirements. Problem: LC devices are crucial for a number of modern technologies including monitors, electronic switches, and storage devices. These devices rely on an optoelectrical process by which applied...
Published: 7/30/2024   |   Inventor(s): Shu Yang, Yu Xia, Timothy Atherton, Douglas Cleaver, Andrew DeBenedictis, DaeSeok Kim
Keywords(s): Optics & Photonics 
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials
PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes
This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy...
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Lixin Lang, Gang NIU
Keywords(s):  
Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology
Radiotherapy and Imaging Agent-based on Peptide Conjugated to Novel Evans Blue Derivatives with Long Half-life and High Accumulation in Target Tissue
This technology includes a newly designed, truncated Evans Blue (EB) form which allows labeling with metal isotopes for nuclear imaging and radiotherapy. Unlike previous designs, this new form of truncated EB confers site specific mono-labeling of desired molecules. The newly designed truncated EB form can be conjugated to various molecules including...
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss
Keywords(s):  
Category(s): ResearchProducts > Research Equipment, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
Evans Blue Modified Small Molecule-based Prostate-specific Membrane Antigen (PSMA) Radiotherapy and Nuclear Imaging
This technology includes anti-PSMA antibody labeled with 177Lu, which has shown to be an effective treatment for prostate cancer. Several small molecules targeting PSMA were also evaluated in prostate cancer patients labeled with betta emitters such as 177Lu. The most common one is 177Lu-PSMA-617 which is under clinical evaluation in many countries....
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Oncology
PRIME: A Personalized Recommendation for Information Visualization Methods via Extended matrix Completion
Information visualization is an important mode of human-computer interaction to acquire insights of complex datasets. However, a uniform visualization format may be inefficient to bring the insights to different users at different contexts due to the users' differences in knowledge, perception, and cognition capabilities. On the other hand, typical...
Published: 10/27/2023   |   Inventor(s): Ran Jin, Chen Xiaoyu, Nathan Lau
Keywords(s):  
Category(s): Technology Classifications > Software, Technology Classifications > Communication
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Evans Blue Dye Derivatives for Serum Albumin Labeling
The invention is an imaging agent and method of use for imaging blood pools and the lymphatic system. The imaging agent binds with high affinity to serum albumin, the most abundant serum protein, and can be tagged with several isotopes making it suitable for magnetic resonance imaging or positron emission tomographic imaging. To date, only very few...
Published: 10/28/2024   |   Inventor(s): Lixin Lang, Gang NIU, Xiaoyuan (Shawn) Chen
Keywords(s): Albumin, BLUE, CA2BXX, Evans Blue, fluorene-18, IA4AXX, LABELED, LABELING, Listed LPM Fenn as of 4/15/2015, Magnetic Resonance, PET, Pet imaging, positron emission, Positron-Emitting, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PXXXXX
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Consumer Products, Application > Diagnostics, Application > Research Materials
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