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Search Results - weicheng+liu
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Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024
|
Inventor(s):
Jingxing Ou
,
Kiyoharu Miyagishima
,
Guanghui Jin
,
Wei Li
,
Lihao Ge
Keywords(s):
Category(s):
Application
,
Application > Research Materials
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 9/12/2024
|
Inventor(s):
Jianfeng Cai
,
Heng Liu
Keywords(s):
Alzheimer's Disease
,
Biotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Neuroscience
Biomimetic high-strength bone implant polymer material
Problem Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
Published: 4/12/2024
|
Inventor(s):
Wei Li
,
Hanyu Zhu
,
Vincent Wang
Keywords(s):
Category(s):
Life sciences > Biomaterials
,
Life sciences > Therapeutics > Synthetic biology
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024
|
Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
Knitted strain sensor for pharyngeal rehabilitation
Problem Dysphagia, or swallowing dysfunction, affects 9.5 million people in the United States. Dysphagia poses significant risks including malnutrition, dehydration, aspiration pneumonia, and death. Dysphagia is associated with diseases including stroke, muscular dystrophy, and throat cancer. The impact of dysphagia extends beyond physical discomfort,...
Published: 2/15/2024
|
Inventor(s):
Jonathan Chen
,
James Sulzer
,
Corinne Jones
,
David Zhang
,
Drake Rowland
,
Wei Li
Keywords(s):
Category(s):
Life sciences > Medical technology > Medical devices
,
Life sciences > Diagnostic
Nutraceuticals for Preventing Leaky Gut
Image Legend: Control intestinal organoids and organoids conditioned to have a leak, or more permeable barrier, were treated with nutraceuticals which clearly prevented increased permeability in the “leaky” organoids. Similar findings were observed in cell culture and in vivo Invention Summary: More than 22 million Americans...
Published: 5/7/2024
|
Inventor(s):
Ronaldo Ferraris
,
Nan Gao
,
Wei Li
Keywords(s):
Category(s):
Technology Classifications > Food, Nutrition and Nutraceuticals
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 8/17/2023
|
Inventor(s):
Ada Poon
,
Cheng Chen
,
Joonseok Yang
,
Hui Wang
Keywords(s):
EEG
,
Neurology
,
Wearable
Category(s):
Technology Classifications > Engineering
Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages
Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...
Published: 4/8/2024
|
Inventor(s):
Jingxing Ou
,
Wei Li
,
Kiyoharu Miyagishima
Keywords(s):
Cold Storage
,
Cold-sensitive
,
Hypothermia
,
lysosome
,
Mitochondria
,
National Eye Institute
,
NEI
,
neural injury
,
Ou
,
Protein Degradation
,
TRANSPLANTATION
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Cardiology
,
Application > Research Materials
,
TherapeuticArea > Opthamology
,
TherapeuticArea > Eye / Ear / Nose / Throat
,
TherapeuticArea > Nephrology
Establishment of Induced Pluripotent Stem Cells (iPSC) from the Thirteen-lined Ground Squirrel
Abstract: The limited choice in cell types available for in vitro studies has become an obstacle in hibernation research. Researchers at the National Eye Institute for the first time have successfully established iPSC line(s) from a mammalian hibernator, which can be potentially used to generate various cell types and tissue models for in-depth mechanistic...
Published: 4/8/2024
|
Inventor(s):
Jingxing Ou
,
Barbara Mallon
,
Wei Li
Keywords(s):
cellular stress
,
coldness
,
hibernation
,
Induced Pluripotent Stem Cell (iPSC)
,
Li
,
neural injury
,
Squirrel
Category(s):
Application > Research Materials
,
Collaboration Sought > Licensing
,
TherapeuticArea > Neurology
Thermal Drift Calibration of Whispering Gallery Mode Microcavities using Optical Frequency Domain Reflectometry
This technology utilizes optical frequency domain reflectometry (OFDR) to collect high resolution temperature measurements in biochemical applications. More specifically, accuracy of measurements is increased in the spatial domain via the OFDR technology being studied in conjunction with whispering gallery mode biochemical sensing. While temperature...
Published: 6/6/2024
|
Inventor(s):
Tsu-Te Su
,
Cheng Li
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Telecommunications > Electro-Optic Devices
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