Search Results - therapeuticarea+%3e+reproductive+health

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First in class Small Molecule Agonists of the mammalian Relaxin family receptor 1 (RXFP1) and use in treatment of cancer, fibrotic, and vascular disorders (HHS Ref No. E-145-2024-0-US-02)
It is well documented in literature that activation of RXFP1 by relaxin induces: 1) up-regulation of the endothelin system which leads to vasodilation; 2) extracellular matrix remodeling through regulation of collagen deposition, cell invasiveness, proliferation, and overall tissue homeostasis; 3) a moderation of inflammation by reducing levels of inflammatory...
Published: 5/29/2025   |   Inventor(s): Juan Marugan, Mark Henderson, Kenneth Wilson, Wenwei Huang, Wenjuan Ye, Noel Southall, Jiankang Jiang, Khalida Shamim, Bing Li, Alexander Agoulnik, Abhijeet Kapoor, Joshua Hutcheson, Ana Cabrera, Irina Agoulnik
Keywords(s):  
Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Pulmonology, TherapeuticArea > Dermatology, TherapeuticArea > Reproductive Health, TherapeuticArea > Geriatrics
Nanobody–Antiviral Peptide Conjugates for Potent HIV Entry Inhibition
This technology includes a new class of nanobody–antiviral peptide conjugates that block HIV from infecting human CD4⁺ T-cells, positioning them for future therapeutic and prophylactic use. Nanobodies—single-domain antibody fragments—guide the drug to the virus’s docking site and impede receptor binding, while the linked peptide...
Published: 5/14/2025   |   Inventor(s): Ross Cheloha, Shubhra Saha
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease, TherapeuticArea > Reproductive Health
A Wearable Device for Monitoring Pregnancy Health
Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for clinical validation and to further develop the technology. Description of Technology: Observing the placenta during pregnancy offers a look into the utero fetal environment. Monitoring...
Published: 4/22/2025   |   Inventor(s): Amir Gandjbakhche, Thien Nguyen, Zeyu Zhang, Soongho Park, George Downey, Alireza Khaligh, Kosar Khaksari
Keywords(s):  
Category(s): Application, Application > Medical Devices, TherapeuticArea > Reproductive Health, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Levonorgestrel Butanoate Formulation and Methods Relating Thereto
Abstract: This invention is a potential subcutaneous or intramuscular progestin-only, injectable contraceptive for women. Forty-five percent (45%) of pregnancies in the United States are unintended. In this group, one-third of reproductive age women are obese – increasing the risk of diabetes, hypertension and venous thromboembolism (VTE). All these...
Published: 4/22/2025   |   Inventor(s): Min Lee, Diana Blithe, Jia-Hwa Fang, Eduardo Ruiz, Ken Chen
Keywords(s): Blithe, CONTRACEPTIVE, INJECTABLE, LB, Lee, Levonorgestrel, Levonorgestrel Butanoate, LNG, National Institute of Child Health and Human Development, NICHD, Steroidal Progestin
Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Reproductive Health
Mouse Embryo Culture Chamber and Imaging System and Methods of Use
Abstract: The culture of mouse embryos ex utero and continuous monitoring and imaging of embryos as they develop have applications in drug testing, genetic studies, and basic research on embryonic development. However, the embryo culture systems currently available for post-implantation embryos include rolling bottle culture systems, which do not permit...
Published: 5/15/2025   |   Inventor(s): Vijay Kalaskar
Keywords(s): Culture Chamber, Embryo Development, Embryonic, FETAL, GENE THERAPY, IMAGING, In Vitro Drug Toxicology, Kalaskar, National Eye Institute, NEI, Organ System Therapy
Category(s): Application > Non-Medical Devices, TherapeuticArea > Reproductive Health, Application > Medical Devices, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
New Insect Sf9-ET Cell Line for Determining Baculovirus Titers
Abstract: The baculovirus-based protein expression system has gained increased prominence as a method for expressing recombinant proteins that are used in a wide range of biomedical applications. An important step in the use of this system is the ability to determine the virus infectious titer, i.e., the number of active baculovirus particles produced...
Published: 4/22/2025   |   Inventor(s): Ralph (Butch) Hopkins, Dominic Esposito
Keywords(s): Baculovirus, Baculovirus Titer, Esposito, IMMUNE, Inflammation, Insect Cell Line, Protein Expression Sf9-ET
Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, TherapeuticArea > Reproductive Health, TherapeuticArea > Nephrology, Application > Research Materials, TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
Monomeric and Oligomeric Compounds as Contraceptives and Endocrine Therapeutics
Abstract: The options for male contraceptives are limited. Research is ongoing to develop a male contraceptive based on hormonal activity. Testosterone is one of the hormones necessary in producing sperm. Testosterone is absolutely required as a hormone for male fertility. Derivatives of testosterone for male contraceptives currently in clinical trials...
Published: 4/22/2025   |   Inventor(s): Min Lee, Diana Blithe, Pranab Gupta, Bashir Kaskar, Ming-Teh Lin
Keywords(s): Blithe, CONTRACEPTIVE, Estrogenic Activity, Eunice Kennedy Shriver National Institute of Child Health an, Lee, Male Contraceptive, MONOMERIC, NCE, New Chemical Entity, NICHD, OLIGOMERIC
Category(s): Application > Therapeutics, TherapeuticArea > Reproductive Health, TherapeuticArea > Endocrinology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
A peptide hydrogel for use in vascular anastomosis
Abstract: In collaboration with surgery specialists from Johns Hopkins University, researchers at the National Cancer Institute (NCI) developed novel hydrogel compositions and methods of using them in the microsurgical suturing of blood vessels, which is particularly beneficial for surgeons in whole tissue transplant procedures. The lead candidate electropositive...
Published: 4/22/2025   |   Inventor(s): Joel Schneider, Gerald Brandacher, Daniel Smith, Gabriel Brat, Johanna Grahammer
Keywords(s): Anastomosis, Hydrogel, Microsurgery, Peptide, Schneider, Surgery
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Non-Medical Devices, TherapeuticArea > Reproductive Health, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Gastroenterology, TherapeuticArea > Cardiology, TherapeuticArea > Nephrology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
Nandrolone 17 Beta-Carbonates
Abstract: The available options for male contraceptives are limited. Androgens are administered as part of hormone-based male contraception and have also been used in the treatment of hypogonadism and hormone replacement therapy HRT. Many synthetic androgens require an oil-based delivery vehicle and have limited durations of action. This technology...
Published: 4/22/2025   |   Inventor(s): Richard Blye, Hyun Kim, Min Lee
Keywords(s): 19-nortestosterone, Androgenic Compounds, Blye, Male Contraceptive, Nandrolone, National Institute of Child Health and Human Development, NICHD
Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Reproductive Health
Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus
Abstract: Baculoviruses have been used for decades to produce proteins in insect cell hosts. Current systems for generating recombinant baculovirus have several shortcomings which prevent their easy use in high-throughput applications.  Researchers within the Frederick National Laboratory for Cancer Research have developed an improved system called...
Published: 4/22/2025   |   Inventor(s): Dominic Esposito, Carissa Grose
Keywords(s): B2F, Bac-2-the-Future, Baculovirus, Esposito, Insect Cells, Protein Production
Category(s): TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Nephrology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
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