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Radially Symmetric Multi-Well Plate for Reduced Experimental Variability
Symmetric Well Design Standardizes Biological Assays Most biological-based assays are performed in multi-well plates consisting of circular wells arranged in a tic-tac-toe pattern inside a rectangular plate. Although this design is universal, in practice it results in significant variability in experimental results across wells. For example, wells...
Published: 1/20/2026   |   Updated: 8/16/2024   |   Inventor(s): Donald Phinney, Siddaraju Boregowda
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Others
Archaeal Enzyme Complex for Multifunctional Nucleic Acid Degradation
Activates Disparate Degradation Processes Using Tunable Concentration of RecJ Enzymes This nuclease complex integrates enzymes from an extremophile single-celled organism into a nuclease with versatile nucleic acid degradation abilities. Nucleases, a class of enzymes within cells, degrade nucleic acids by breaking long strands into shorter ones. Ribonuclease...
Published: 1/20/2026   |   Updated: 7/3/2024   |   Inventor(s): Julie Maupin, Huiyong Jia, Swathi Dantuluri
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Others, Technology Classifications > Research Tools > Biological Materials
Mitotherapeutics for the Treatment of Neurological or Psychiatric Disorders
Small Molecule Modulators for Improving Mitochondrial Dysfunction These small molecules exhibit modulatory effects on neuronal mitochondrial dynamics for potentially treating patients suffering from neurological or psychiatric disorders. Brain and other central nervous system (CNS) disorders, particularly neurodegenerative disorders such as Alzheimer’s...
Published: 1/20/2026   |   Updated: 4/6/2023   |   Inventor(s): Ronald Davis, Courtney MacMullen, Boglarka Varkuti, Ze Liu, Miklos Kepiro
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Others
Two Novel PCR-Based Methods for Site-Directed Mutagenesis of Large Plasmids
Efficiently and Accurately Introduces Site-Directed Modifications in Large Plasmids These two novel polymerase chain reaction (PCR)-based methods enable efficient generation of substitution mutations in large plasmids (>10 kb). Site-directed mutagenesis is a common tool in the molecular biology field, allowing for a better understanding of the influence...
Published: 1/20/2026   |   Updated: 12/21/2022   |   Inventor(s): Julie Maupin, Huiyong Jia
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Others, Technology Classifications > Research Tools > Biological Materials
Monoclonal Antibodies against Heterogeneous Nuclear Ribonuclear Proteins (hnRNP) m3/4 & m1-4
Recognize hnRNP-M3 As WellHeterogeneous nuclear ribonucleoproteins (hnRNPs), which directly bind to nascent RNA polymerase II transcripts, play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. These "M proteins" are pre-mRNA-binding proteins in vivo, and they bind to poly(G) and poly(U) RNA homopolymers...
Published: 1/20/2026   |   Updated: 2/23/2021   |   Inventor(s): Maurice Swanson
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Others
Mouse Model of C9orf72 that Develops the Clinical and Neurodegenerative Features of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Recapitulates Features of ALS and FTD using a Patient Derived Human TransgeneExpansion of the number of repeats of a specific hexanucleotide sequence (GGGGCC, called G4C2) in the C9orf72 gene is the most common known cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). This C9-500 mouse model contains a mutation with 500 G4C2...
Published: 1/20/2026   |   Updated: 6/14/2019   |   Inventor(s): Laura Ranum
Keywords(s): Amyotrophic lateral sclerosis (ALS), C9ORF72, C9ORF72 BAC mouse model, Frontotemporal Dementia (FTD), repeat associated non-ATG (RAN)-Translation
Category(s): Technology Classifications > Research Tools > Others
Nanoparticles with Improved Magnetic Capacity
Produces Nanoparticles in Which the Particle's Magnetic Core Size Closely Matches Its Physical SizeThese magnetic nanoparticles have greater magnetic capacity, translated to improved functional properties, than magnetic nanoparticles available, potentially decreasing the costs of nanoparticle used in a broad range of industrial and biomedical applications....
Published: 1/20/2026   |   Updated: 5/17/2019   |   Inventor(s): Mythreyi Unni, Carlos Rinaldi
Keywords(s): Magnetic Drameter, Magnetic Nanoparticle, Magnetically Dead Layer, magnetite, Nanoparticle, Nanotechnology
Category(s): Technology Classifications > Engineering, Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials, Technology Classifications > Engineering > Others, Technology Classifications > Medical Devices > Consumable, Technology Classifications > Research Tools > Others
Adaptive System that Records Cellular Lineage, Cellular Clock, and Cellular Memory Simultaneously
Diary Reveals a Comprehensive History of a Cell that Aids Research, Diagnostics, and TherapeuticsThis molecular cell diary system is capable of creating a detailed understanding of a cell’s history and current state, including its cellular lineage, cellular clock, and cellular memory. The molecular diagnostics market in 2014 was globally worth...
Published: 1/20/2026   |   Updated: 5/17/2019   |   Inventor(s): Son Le, David Tran
Keywords(s): cellular barometer, cellular clock, cellular events tracking, cellular memory, lineage tracing, mutational history
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Research Tools > Diagnostics, Technology Classifications > Research Tools > Others, Technology Classifications > Research Tools > Vectors, Technology Classifications > Software > Others
Biocatalysts for Generating Nitroaromatics in an Environmentally-Friendly Manner
Efficient, Environmentally Sustainable Approach for Aromatic NitrationThese biocatalysts can generate novel nitroaromatic end products and building blocks for the synthesis of more complex compounds in an environmentally friendly manner. Nitro aromatic and heterocyclic derivatives are important industrial chemicals that are used as food additives, pesticides,...
Published: 1/20/2026   |   Updated: 5/15/2019   |   Inventor(s): Yousong Ding
Keywords(s): catalyst, direct nitration, enzyme process, P450, Research Tool, self-sufficient
Category(s): Technology Classifications > Research Tools > Others
Fast and Scalable Heterogeneous Catalysis for Sensitivity-Enhanced MRI and NMR That Works in Low Magnetic Fields
Polarizes Water Molecules from Parahydrogen to Intensify Their Nuclear Magnetic Resonance Signals for Detection in Low Magnetic FieldsThe use of hyperpolarized water as a contrast agent in magnetic resonance imaging (MRI) could dramatically shorten scanning times for patients, provide new imaging modalities, and avoid the risks associated with conventional...
Published: 1/20/2026   |   Updated: 5/14/2019   |   Inventor(s): Evan Zhao, Clifford Bowers
Keywords(s): catalyst, hydrogen, hyperpolarized water from Parahydrogen, MRI, NMR, parahydrogen, Platinum, Water, water calayst
Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Medical Devices > Consumable, Technology Classifications > Medical Devices > Equipment, Technology Classifications > Research Tools > Others, Technology Classifications > Veterinary > Diagnostics
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