Search Results - laura+ranum

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Mouse Model of C9orf72 that Develops the Clinical and Neurodegenerative Features of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Recapitulates Features of ALS and FTD using a Patient Derived Human TransgeneExpansion of the number of repeats of a specific hexanucleotide sequence (GGGGCC, called G4C2) in the C9orf72 gene is the most common known cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). This C9-500 mouse model contains a mutation with 500 G4C2...
Published: 6/27/2021   |   Inventor(s): Laura Ranum
Keywords(s): Amyotrophic lateral sclerosis (ALS), C9ORF72, C9ORF72 BAC mouse model, Frontotemporal Dementia (FTD), repeat associated non-ATG (RAN)-Translation
Category(s): Technology Classifications > Research Tools > Others
Protein Biomarkers that Help Improve Diagnosis and Treatment of Huntington’s Disease
Biomarkers Enable Testing for Treatment Effectiveness, Help Improve Disease Outcomes, and Allow for Possible Future Prognosis Markers Four RAN biomarkers not previously known to accumulate in Huntington’s disease have been discovered in a higher abundance in the brains of those affected by the disease and in early onset juvenile cases. More than...
Published: 6/27/2021   |   Inventor(s): Laura Ranum, Monica Banez Coronel
Keywords(s): Huntington's disease, Non-ATG translation, Novel HD RAN proteins, RAN proteins
Category(s): Technology Classifications > Human Health Care > Therapeutics