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Search Results - technology+classifications+%3e+research+tools+%3e+biological+materials
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Archaeal Enzyme Complex for Multifunctional Nucleic Acid Degradation
Activates Disparate Degradation Processes Using Tunable Concentration of RecJ Enzymes This nuclease complex integrates enzymes from an extremophile single-celled organism into a nuclease with versatile nucleic acid degradation abilities. Nucleases, a class of enzymes within cells, degrade nucleic acids by breaking long strands into shorter ones. Ribonuclease...
Published: 9/4/2024
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Inventor(s):
Julie Maupin
,
Huiyong Jia
,
Swathi Dantuluri
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Others
,
Technology Classifications > Research Tools > Biological Materials
Biofunctional Hydrogel to Treat Chronic Inflammatory Diseases
Inhibits the Activation of Pro-Inflammatory Macrophages, Delivering a Therapeutically Effective Amount of DGEA to the Inflammation Site This hydrogel composition inhibits the activation of pro-inflammatory macrophages, treating diseases and disorders associated with excessive or sustained inflammation. Inflammation is the body’s defense mechanism...
Published: 9/3/2024
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Inventor(s):
Erika Moore
,
Aakanksha Jha
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Biological Materials
Two Novel PCR-Based Methods for Site-Directed Mutagenesis of Large Plasmids
Efficiently and Accurately Introduces Site-Directed Modifications in Large Plasmids These two novel polymerase chain reaction (PCR)-based methods enable efficient generation of substitution mutations in large plasmids (>10 kb). Site-directed mutagenesis is a common tool in the molecular biology field, allowing for a better understanding of the influence...
Published: 2/22/2024
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Inventor(s):
Julie Maupin
,
Huiyong Jia
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Others
,
Technology Classifications > Research Tools > Biological Materials
Glycan Binding Protein Can Detect, Isolate, and Purify Therapeutic Proteins and Antibodies
Glycan Binding Protein Derived from Common, Inexpensive Mushrooms The recombinant glycan-binding protein Ab-Y3, found in an edible, common mushroom, is useful for detecting, isolating, purifying, and screening proteins with specific N-glycans of medical significance, such as immunoglobins or IgG proteins. Glycan binding proteins are critical for a...
Published: 9/7/2022
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Inventor(s):
Yousong Ding
,
Steven Bruner
,
Peilan Zhang
,
Brian MacTavish
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Biological Materials
Genetically Improved Bacterium Strain That Efficiently Produces High Yields of Vitamin B12
Efficiently Synthesizes Vitamin B12 for Higher Yields at Lower-Cost Commercial Production This genetically modified strain of bacteria dramatically increases the amount of vitamin B12 produced by the Propionibacterium. Commercial production of vitamin B12 supplements commonly uses Propionibacterium, and this genetically modified strain can increase...
Published: 2/22/2024
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Inventor(s):
Mansour M. Zadeh
Keywords(s):
Cobalamin
,
Probiotic
,
Vitamin B12
Category(s):
Technology Classifications > Research Tools > Biological Materials
Analytical System to Identify Glycolipids and Glycosphingolipids in Tissues
Mass Spectrometry Database and Software Improves Characterization of Complex and Unknown Glycolipids This liquid chromatography, tandem mass spectrometry (LC-MS/MS) system utilizes an extensive mass spectrometry database and a two-step searching procedure to identify glycolipids and glycosphingolipids. Glycolipids play an important role in various...
Published: 6/27/2021
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Inventor(s):
Zhongwu Guo
,
Jinying Zhao
,
Kari Basso
,
Laura Bailey
,
Tianqi Gao
,
Fanran Huang
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Diagnostics
,
Technology Classifications > Research Tools > Biological Materials
Enzymes and Genetic Constructs That Enable Genetic Engineering of Many Bacterial Species Considered Difficult to Engineer
Enables Scientists to Produce Plasmid, or Other Genetic Mobile Element, DNA That Is Resistant to Degradation by Bacterial Restriction EnzymesThese tools being developed by UF’s scientists produce modifications to plasmid or phage DNA that make the plasmid or phage resistant to a wide range of endonucleases. The common processes used to modify...
Published: 2/22/2024
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Inventor(s):
Valerie De Crecy
,
Geoffrey Hutinet
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Biological Materials
Oppositely Charged Synthetic Peptides for Biomaterials with Immobilized Functional Proteins
Installs Folded Proteins into Supramolecular Assemblies that Demonstrate Properties Such As Molecular Recognition, Antigen Presentation, Tunable Drug Release, Catalysis or FluorescenceThis pair of synthetic peptides spontaneously self-assembles into a biomaterial with a precise supramolecular architecture with functional capabilities. The biomaterials...
Published: 6/27/2021
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Inventor(s):
Gregory Hudalla
,
Dillon Seroski
Keywords(s):
Biomaterials
,
charge-complementary peptides
,
Folded proteins
,
Nanotechnology
,
Recombinant protein
,
Tags
Category(s):
Technology Classifications > Engineering > Materials
,
Technology Classifications > Human Health Care > Others
,
Technology Classifications > Medical Devices > Others
,
Technology Classifications > Research Tools > Biological Materials
,
Technology Classifications > Research Tools > Others
Panel of Monoclonal Antibodies for Characterization of AAV8 and AAV9 Capsids to Improve Therapeutic Efficacy of AAV Gene-Based Therapy
More Accurately Characterizes AAV8 and AAV9 Capsids for Development of Next Generation Vectors to Evade the Host's Immune Response This panel of antibodies allows better characterization of antigenic epitopes on AAV8 and AAV9 capsids with the goal of mitigating patient immune response to the existing AAV based gene therapy. Adeno-associated viral (AAV)...
Published: 6/27/2021
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Inventor(s):
Mavis Agbandje-McKenna
,
Kim Van Vliet
,
Yu-Shan Tseng
Keywords(s):
AAV Vectors
,
Antibody
,
Antibody-based assay
,
dot blot
,
Elisa
,
Hybridoma
Category(s):
Technology Classifications > Research Tools > Biological Materials
Antibodies and ELISA for Chondroitinase ABC
ELISA Determines ChABC Distribution and Content in Tissues and Bodily FluidsChondroitinase ABC (ChABC) is a bacterial enzyme that degrades sugar chains attached to the core protein of chondroitin sulfate proteoglycans (CSPGs). CSPGs are involved in a variety of biological processes in higher organisms, including humans. ChABC has a well-known potential...
Published: 7/12/2022
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Inventor(s):
David Muir
Keywords(s):
Antibody
,
Chondroitinase
,
Hybridoma
,
Immunochemistry
,
Monoclonal
,
Monoclonal Antibody
,
Research
Category(s):
Technology Classifications > Research Tools > Biological Materials
,
Technology Classifications > Research Tools > Others
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