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Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases Background: Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 9/12/2025   |   Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis. Background: Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 9/12/2025   |   Inventor(s): Stelios Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
A Flexible Multiplexed Amplifier for Multichannel Wearable Biopotential Devices
A compact, multiplexed amplifier architecture for wearable biopotential devices, enabling efficient, multi-channel data processing in a miniaturized, flexible format. Background: High-density biopotential measurement devices, such as EMGs and EEGs, typically require large and cumbersome amplifiers, limiting their applicability in wearable technologies....
Published: 9/12/2025   |   Inventor(s): Filip Stefanovic
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Medical Devices, Technology Classifications > Electronics
High-Frequency, Device-Free mmWave Facial Landmark Sensing
A high-resolution, non-contact facial landmark tracking system that uses millimeter wave (mmWave) technology to achieve precise and efficient facial sensing. Background: MicroFace introduces a novel mmWave-based system for high-resolution, non-contact facial landmark tracking. This system addresses the existing challenge of precise and efficient...
Published: 9/12/2025   |   Inventor(s): Wenyao Xu, Chenhan Xu
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Sensors, Technology Classifications > Information Technology
Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures
A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal. Background: Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 9/12/2025   |   Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering
Compositions and Methods to Promote Endothelialization of Cardiovascular Implants
Provided here are fusion proteins that, when immobilized on the (blood-facing) surface of a cardiovascular implant, promote endothelialization, which is critical for long-term biocompatibility. Background: A major challenge to the clinical utilization and success of off-the-shelf vascular grafts (e.g. decellularized, devitalized and non-biologic/polymeric...
Published: 9/12/2025   |   Inventor(s): Stelios Andreadis, Randall Smith, Bita Nasiri
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering
Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics
This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications. Background: There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...
Published: 9/11/2025   |   Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Bioinformatics, Technology Classifications > Artificial Intelligence, Technology Classifications > Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Healthcare, Technology Classifications > Diagnostics, Technology Classifications > Dental
RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 5/13/2025   |   Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses
This technology provides a valuable tool for studying the molecular and cellular basis of dental plaque-mediated diseases. Background: In vitro oral microcosm communities, seeded with mixed communities of human dental plaque, have proven to be essential tools for studying the taxonomic composition of dental plaque communities and changes in community...
Published: 5/13/2025   |   Inventor(s): Alex Valm
Keywords(s): biofilm control, dental, dental materials, structural biology, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Dental, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care
A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background: Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 5/13/2025   |   Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
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