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Enhanced Fluorophore Discrimination in Fluorescence Microscopy Using Multi View Spectral Unmixing with Photobleaching Dynamics
This technology allows researchers to more easily distinguish hundreds of fluorescent labels in a single image, useful for a wide variety of biological applications. Background: There are hundreds to thousands of different cells or other structures that can be labeled with fluorescent reporters in a biological sample, and then imaged on a fluorescence...
Published: 10/24/2025   |   Inventor(s): Alex Valm, Yunlong Feng, Ruogu Wang
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Bioinformatics, Technology Classifications > Artificial Intelligence, Technology Classifications > Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Healthcare, Technology Classifications > Diagnostics, Technology Classifications > Dental
RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 10/24/2025   |   Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses
This technology provides a valuable tool for studying the molecular and cellular basis of dental plaque-mediated diseases. Background: In vitro oral microcosm communities, seeded with mixed communities of human dental plaque, have proven to be essential tools for studying the taxonomic composition of dental plaque communities and changes in community...
Published: 10/29/2025   |   Inventor(s): Alex Valm
Keywords(s): biofilm control, dental, dental materials, structural biology, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Dental, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
Raman Spectroscopy for Testing Stability of RNA-based Vaccines and Drugs
A fast, less expensive, and more reliable method for assessing mRNA degradation in vaccines, that can also be used as a tool for the development of new RNA-based therapeutics. Background: The development of mRNA-based vaccines for COVID-19 offers the potential for a new medical paradigm based on RNA technology. Unfortunately, these drugs require...
Published: 10/29/2025   |   Inventor(s): Igor Lednev, Alexander Shekhtman, Lamyaa Almehmadi, Sergei Reverdatto
Keywords(s): drug stability, mRNA, mRNA stability, Raman spectroscopy, RNA, Technologies, vaccine stability, vaccines
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 10/24/2025   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Ribonuclease-responsive DNA Nanoswitches
A DNA nanoswitch that provides a simple mix-and-read methodology to detect RNases (ribonucleases) in a biological sample. Background: RNases are involved in many biological processes including neurotoxicity, genome replication and maintenance, immune-suppression, and antitumor activity. RNase inhibitors are also potential drug candidates and biomarkers...
Published: 10/24/2025   |   Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran
Keywords(s): DNA, RNA, RNA-switch
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents, Technology Classifications > Diagnostics
Expression of Human Isoferritins
A technology that can express and purify a variety of human heteropolymer isoferritins of various ratios. Background: Ferritin is a molecule resent in mammals, which serves the primary function of sequestering ferrous iron and inducing its mineralization. In mammals, and most saliently in humans, ferritins exist as a co-assembled heteropolymers. Ferritin...
Published: 10/24/2025   |   Inventor(s): Fadi Bou-Abdallah
Keywords(s):  
Category(s): Campus > SUNY Potsdam, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Medical Devices
Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases Background: Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 9/12/2025   |   Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis. Background: Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 9/12/2025   |   Inventor(s): Stelios Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
A Flexible Multiplexed Amplifier for Multichannel Wearable Biopotential Devices
A compact, multiplexed amplifier architecture for wearable biopotential devices, enabling efficient, multi-channel data processing in a miniaturized, flexible format. Background: High-density biopotential measurement devices, such as EMGs and EEGs, typically require large and cumbersome amplifiers, limiting their applicability in wearable technologies....
Published: 10/22/2025   |   Inventor(s): Filip Stefanovic
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Medical Devices, Technology Classifications > Electronics
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