Search Results - shivkumar+kalyanam

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One-Bead-Two-Compound Macrocyclic Library and Methods of Preparation and Use
Competitive Advantages Chemo diversity, enhanced conformational rigidity, and greater protease resistance Increased conformational constraint and binding affinity Proven method of drug discovery Summary Combinatorial chemistry serves as a powerful tool for ligand screening against potential protein and peptide targets. However, macrocyclic peptidomimetic...
Published: 2/9/2024   |   Inventor(s): Jianfeng Cai, Yan Shi
Keywords(s):  
Category(s): Technology Classifications > Cancer
Helical Sulfono-γ-AApeptide Antagonize β-Catenin Signaling
Competitive Advantages Potent, specific, and cell permeable to target intracellular PPIs High stability against enzymatic degradation More effective than other peptides at antagonizing Wnt/β-catenin signaling Summary Protein-protein interactions (PPIs) are vital to the survival of cancer cells and are therefore a good target for anti-cancer...
Published: 7/17/2023   |   Inventor(s): Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang
Keywords(s): Cancer, Cancer Treatment Leukemias, Cancer Treatment Lymphomas, Peptides, Therapeutics
Category(s): Technology Classifications > Cancer
2017-997 Neural Modulation of Autonomic Nervous System to Alter Memory and Plasticity of the Autonomic Network
SUMMARY: Researchers at UCLA from the Departments of Medicine and Bioengineering have created a device that modulates the autonomic nervous system to treat heart conditions like arrhythmias.BACKGROUND:The autonomic nervous system controls unconscious bodily functions like breathing and maintaining heart function. The cardiac autonomic nervous system...
Published: 7/19/2023   |   Inventor(s): Kalyanam Shivkumar, Marmar Vaseghi, Jeffrey Ardell
Keywords(s):  
Category(s): Medical Devices > Surgical Tools, Therapeutics > Cardiovascular
2018-375 SPATIO-TEMPORAL PACING AND RECORDING FOR EVALUATION, INDUCTION, AND MAPPING OF ARRHYTHMIAS
Spatio-Temporal Pacing and Recording for Evaluation, Induction, and Mapping of ArrhythmiasSUMMARYResearchers led by Marmar Vaseghi from the School of Medicine at UCLA have developed a high density electrode array to evaluate, induce, and map arrhythmias.BACKGROUNDCardiac arrhythmias are abnormal heartbeats that arise from malfunctions of electrical...
Published: 7/19/2023   |   Inventor(s): Marmar Vaseghi, Jeffrey Ardell, Shivkumar Kalyanam
Keywords(s): Cardiovascular, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Devices and Materials, Monitoring And Recording Systems, Therapeutics & Vaccines
Category(s): Diagnostic Markers, Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Diagnostic Platform Technologies, Therapeutics, Therapeutics > Cardiovascular
2015-792 Vagal Suppression of Neurally-Induced Atrial Fibrillation
Vagal Suppression Of Neurally-Induced Atrial FibrillationSUMMARYUCLA researchers in the Department of Cardiology have identified a novel mechanism for controlling atrial fibrillation via neuromodulation.BACKGROUNDAtrial fibrillation (AF), an abnormal heart beat characterized by rapid and irregular beating, affects more than 3 million people in the United...
Published: 7/19/2023   |   Inventor(s): Jeffrey Ardell, Kalyanam Shivkumar
Keywords(s): Cardiovascular, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Cardiovascular
2008-626 A Method to Protect the Esophagus and Other Mediastinal Structures During Cardiac and Thoracic Interventions
A Method to Protect the Esophagus and Other Mediastinal Structures During Cardiac and Thoracic InterventionsSUMMARYUCLA researchers in the Division of Cardiology at the Geffen School of Medicine have developed a novel device that provides protection of esophagus and other surrounding mediastinal structures when the pericardial space is accessed by interventional...
Published: 7/19/2023   |   Inventor(s): Kalyanam Shivkumar
Keywords(s): Cardiovascular, Medical Devices and Materials
Category(s): Medical Devices, Therapeutics > Cardiovascular
2008-788 A Novel Method and Apparatus to Access the Left Heart for Cardiac Interventions
A Novel Method and Apparatus to Access the Left Heart for Cardiac InterventionsSUMMARYUCLA researchers in the Division of Cardiology at the Geffen School of Medicine have developed novel devices and methods for allowing entirely intravascular access to the left ventricle, thereby precluding access via the apex of the heart percutaneously or by surgery.BACKGROUNDMany...
Published: 7/19/2023   |   Inventor(s): Kalyanam Shivkumar
Keywords(s): Cardiovascular, Medical Devices and Materials
Category(s): Medical Devices, Therapeutics > Cardiovascular