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Search Results - roman+manetsch
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Fragment Evolution via Kinetic Target-Guided Synthesis for the Identification of Potent Bcl-2 Modulators
Competitive Advantages Increased throughput by 200-fold Can be applied to any biological target Identifies previously "undruggable" targets Increased sensitivity Summary USF researchers have developed an improved kinetic TGS sample detection method. This technology specifically targets modulating proteins of the Bcl-2 family....
Published: 8/26/2023
|
Inventor(s):
David Flanigan
,
Hong-Gang Wang
,
Iredia Iyamu
,
Jeremiah Tipton
,
Katya Nacheva
,
Kenichiro Doi
,
Megan Barber
,
Niranjan Namelikonda
,
Sameer Kulkarni
,
Roman Manetsch
Keywords(s):
Category(s):
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Cancer
,
Technology Classifications > Medical > Pharmaceuticals
Photo-Labels with Enhanced Ambient Light Stability and Water Solubility
Competitive Advantages Ambient light stability Improved aqueous solubility Efficient in photo-labelling target proteins Summary Our inventors have synthesized an ambient-light stable photo-label without compromising the photo-activated insertion reactivity. The new synthesized photo-label is effective for photo-affinity labeling...
Published: 8/25/2023
|
Inventor(s):
Roman Manetsch
,
Arun Kumar
,
Jeremiah Tipton
Keywords(s):
Category(s):
Technology Classifications > Advance Materials
,
Technology Classifications > Engineering
Acylsulfonamides and Processes for Producing the Same
Competitive Advantages Selective triggering of apoptotic pathway in cancer cells Enhances the body’s natural defense against tumors Decreased damage to healthy cells and tissues Summary USF scientists have designed a novel compound class that shows promise to specifically target the anti-apoptotic Bcl-2 family of proteins,...
Published: 8/27/2023
|
Inventor(s):
Hong-Gang Wang
,
Jiazhi Sun
,
Sameer Kulkarni
,
Xiangdong Hu
,
Roman Manetsch
Keywords(s):
Category(s):
Technology Classifications > Cancer
,
Technology Classifications > Cancer > Cancer Diagnostics
Antimicrobial Activity of Diamino Compounds Against Drug-Resistant A. Baumannii
Competitive Advantages Strong bactericidal activity with limited damage toward human cells Proven effective against drug-resistant MRSA Low incidence of resistance by A. baumannii vs. competitive compounds Summary Researchers at the University of South Florida have identified compounds that have proven to be effective against Acinetobacter...
Published: 6/25/2024
|
Inventor(s):
Roman Manetsch
,
Kurt Van Horn
,
Whittney Burda
,
Lindsey Shaw
,
Renee Fleeman
Keywords(s):
Category(s):
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
Quinolone-Based Compounds, Formulations, and Uses Thereof
Competitive Advantages High aqueous solubility Targets multiple stages of malaria Effective against multidrug resistant malaria strains Prevents malaria infections and treats current infections Summary USF researchers have developed quinolone-based compounds and methods of treatment that can be used to prevent and treat malaria....
Published: 8/25/2023
|
Inventor(s):
Alexis LaCrue
,
Dennis Kyle
,
Jordany Maignan
,
Roman Manetsch
Keywords(s):
Category(s):
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
Treatment of Metabolic Diseases with 5-Aminolevulinate Synthase Inhibitors
Competitive Advantages Effectively inhibits ALAS Treats heme biosynthesis disorders and other ALAS related diseases Easy synthesis and purification technique Summary USF scientists have discovered inhibitors against 5-aminolevulinate synthase. This was achieved via a kinetic target -guided synthesis that was extended to multi-fragment screening...
Published: 6/7/2023
|
Inventor(s):
Roman Manetsch
,
Gloria Ferreira
Keywords(s):
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Endocrinology
,
Technology Classifications > Medical
4(1H)-Quinolones Having Antimalarial Activity with Reduced Chemical Resistance
Competitive Advantages Potent anti-malarial activity Improved chemical resistance against multi-drug resistant (MDR) parasites Acts on both MDR parasites and drug susceptible anti-malarial strains equally well Summary This invention promises a great approach to treat those affected with malaria. The compound possesses a potent EC50...
Published: 8/27/2023
|
Inventor(s):
Alexis LaCrue
,
Dennis Kyle
,
Fabian Saenz
,
Jordany Maignan
,
Niranjan Namelikonda
,
Richard Cross
,
Tina Mutka
,
Roman Manetsch
Keywords(s):
Category(s):
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical
Compounds Having Anti-Parasitic or Anti-Infective Activity
Competitive Advantages Effective on liver and blood stages of malaria Effective against drug-resistant strains of Plasmodium parasites Summary Chloroquine replacement drugs are urgently needed to treat and prevent malaria. The endoperoxides, like artemisinin are being used in other parts of the world for malaria therapy. However, the...
Published: 8/27/2023
|
Inventor(s):
Aaron Nilsen
,
David Hinrichs
,
Dennis Kyle
,
Jane Kelly
,
Jeremy Burrows
,
Martin Smilkstein
,
Michael Riscoe
,
Richard Cross
,
Rolf Winter
,
Roman Manetsch
Keywords(s):
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Pharmaceuticals