Search Results - rna+interference

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Functionally-Interdependent Shape-Switching Nucleic Acid Nanoparticles
Abstract: RNA interference (RNAi) is a naturally occurring post-transcriptional gene regulation process that represses the expression of specific genes. Exploiting endogenous RNAi by externally-delivered small-interfering RNA (siRNA) is a promising therapeutic for the treatment of various diseases representing several major unmet medical needs.  Researchers...
Published: 8/14/2024   |   Inventor(s): Bruce Shapiro, Kirill Afonin, Eckart Bindewald, Mathias Viard, Wojciech Kasprzak, Justin Halman, Marina Dobrovolskaia
Keywords(s): CANCER, Drug Delivery, Molecular imaging, Nanoparticle, RNA interference, RNAi, SiRNA, Small-interfering RNA
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology
siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing
Abstract: RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes.  Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the...
Published: 8/14/2024   |   Inventor(s): Bruce Shapiro, Paul Zakrevsky, Luc Jaeger
Keywords(s): Gene silencing, Nanoparticle, RNA, RNA interference, RNAi, Shapiro, SiRNA
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
Advanced Nanozyme Designs for Developing High Selectivity RNA Silencing Therapeutics
Increases Target Selectivity and Enzymatic Activity of Nanozymes and Improves their Synthesis ProcessThese nanozyme designs use a recombinant RNase A loading mechanism strong enough to support high-density surface packing of DNA oligonucleotides, facilitating stable and reproducible synthesis of nanozymes with high target selectivity and enzymatic activity...
Published: 6/27/2021   |   Inventor(s): Yunwei Cao, Tian Jiang
Keywords(s): nanoparticle composite, Nanozyme, on-off switchable function, RNA Interference
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Drug Delivery