Search Results - luc+jaeger

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Nanoparticles for the targeted treatment of infected cells
Abstract: Current treatments for cancer and viral infection are limited remedies that often suppress cell or viral replication rather than eliminate diseased cells entirely from the body. A further limitation is that these therapies often compromise healthy cells as well, leaving problems of recurrence and side effects. Researchers at developed a novel...
Published: 8/14/2024   |   Inventor(s): Bruce Shapiro, Kirill Afonin, Arti Santhanam, Mathias Viard, Luc Jaeger, Eckart Bindewald
Keywords(s): RNA nanoparticles, SiRNA, viral infections
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Therapeutics
siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing
Abstract: RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes.  Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the...
Published: 8/14/2024   |   Inventor(s): Bruce Shapiro, Paul Zakrevsky, Luc Jaeger
Keywords(s): Gene silencing, Nanoparticle, RNA, RNA interference, RNAi, Shapiro, SiRNA
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
In silico design of RNA nanoparticles
Abstract: RNA nanoparticles have the potential to serve as excellent drug or imaging delivery systems due to their designability and versatility. Furthermore, the RNA nanoparticles of the invention are also capable of self-assembly and potentially form nanotubes of various shapes which offer potentially broad uses in medical implants, gene therapy,...
Published: 8/14/2024   |   Inventor(s): Bruce Shapiro, Yaroslava Yingling, Luc Jaeger, Isil Severcan, Cody Geary, Eckart Bindewald, Wojciech Kasprzak, Kirill Afonin
Keywords(s): nanobiology, Nanoparticle, nanotechnology, RNAi, SiRNA
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Co-Transcriptional Assembly of Modified RNA Nanoparticles
Abstract: The National Cancer Institute seeks parties interested in collaborative research to co-develop a method to generate RNA molecules suitable for nanoparticle and biomedical applications. The development of nanoparticles as a method of drug delivery is paving the way for precise targeted therapy making it a more attractive and effective method...
Published: 8/13/2024   |   Inventor(s): Bruce Shapiro, Kirill Afonin, Maria Kireeva, Mikhail Kashlev, Wade Grabow, Luc Jaeger
Keywords(s): Drug Delivery, Nanoparticle, RNA
Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Network-Coded Multiple Access
[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...
Published: 1/29/2024   |   Inventor(s): Soung Chang Liew, Lu LU, Lizhao You
Keywords(s): Network Coding, Wireless Local Area Network
Category(s): Information and Communications Technology