Search Results - qin+zhang

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COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)

The coronavirus disease 2019 (COVID-19) is caused by a novel RNA enveloped coronavirus, SARS-CoV-2 when the virus enters human airway cells via an ACE2-mediated entry process. This entry pathway is facilitated by the cell surface heparan sulfate proteoglycan (HSPG), which enhances viral attachment to the cell surface. Researchers at NIDDK and NCATS...

Published: 7/25/2024 | Inventor(s): Qi Zhang, Wei Zheng, Catherine Chen, Yihong Ye

Keywords(s): COVID-19, DB4BXX, ENTRY, HEPARAN, option, Sulfate-dependent, Targeting, therapeutic, viral

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics

A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells

Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor...

Published: 7/25/2024 | Inventor(s): Qi Zhang, Yihong Ye

Keywords(s): Cells, HEPARAN, Label, MAMMALIAN, MEMBRANE, Method, PLASMA, PROTEOGLYCAN, R1XXXX, SULFATE, XCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials

Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...

Published: 4/3/2023 | Inventor(s): Leilei Peng, Yu Li, Han Zhang

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry

A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)

Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...

Published: 2/23/2023 | Inventor(s): Fuqing Wu, Samat Bayakhmetov, Changhan He, Qi Zhang, Xingwen Chen, Yang Kuang, Xiao Wang

Keywords(s):

Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology

Pathogen Molecular Detection Platform

Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...

Published: 2/23/2023 | Inventor(s): Qi Zhang, Xiao Wang, Alexander Green, Duo Ma, Fuqing Wu, Kylie Standage-Beier, Xingwen Chen

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors

Model for Gene Expression Tuning and Synthetic Gene Circuit Construction

Genetic circuit engineering has played an important role in many forms of synthetic biology. Based on a large collection of well characterized biological components, complex gene circuits with designed functions can be wired using established biological principles. Currently circuit assembly has two main strategies: one is monocistronic construct, in...

Published: 2/23/2023 | Inventor(s): Fuqing Wu, Xiao Wang, Qi Zhang

Keywords(s):

Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs)

Cellulose Dispersions for Reducing Cold Damage in Tree Fruit

Unmet Need: More cost-effective and less labor-intensive cold damage protection technologyEconomic loss from cold damage is one of the most prevalent recurring production issues in temperate fruit industry, and poses a significant challenge to profitable and sustainable production. Each year, the U.S. produces >15M tons of deciduous fruit crops that...

Published: 8/3/2023 | Inventor(s): Xiao Zhang, Changki Mo, Matthew Whiting, Qin Zhang

Keywords(s):

Category(s): Technologies > Food & Nutrition > Agriculture and Plant Sciences, Technologies > Energy & Environment > Clean Tech, Technologies > Health & Well-being > Chemistry

Underactuated, Tendon-Driven End-Effector for a Robotic Apple Harvester

Abstract Apple picking is very labor intensive and expensive. Between 15-18 billion apples are harvested every year in Washington state alone for fresh market consumption, but often farmers can’t find enough people to pick the fruit. Furthermore, laborers are hard to acquire as apple picking is seasonal. This presents an urgent need for improved...

Published: 5/25/2023 | Inventor(s): Joseph Davidson, Changki Mo, Abhisesh Silwal, Manoj Karkee, Qin Zhang

Keywords(s):

Category(s): Technologies > Next Generation Materials & Technology > Robotics, Technologies > Food & Nutrition > Agriculture and Plant Sciences

Apple harvesting machine for formally trained orchards

Unmet Need: Improved mechanical harvesting techniques for apples and other specialty crop orchards Harvesting labor accounts for 50% of the total tree fruit production cost and this is expected to continue to rise as labor shortages increase. This presents an urgent need for improved mechanical harvesting techniques in apple and other specialty crop...

Published: 5/25/2023 | Inventor(s): Mark De Kleine, Manoj Karkee, Qin Zhang

Keywords(s):

Category(s): Technologies > Food & Nutrition > Agriculture and Plant Sciences, Technologies > Next Generation Materials & Technology > Robotics