Search Results - medical+diagnostics%2fsensors

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Massively Parallel Method to Quantify Protein Folding & Stability
Protein misfolding plays a role in degenerative diseases, cancer evolution, synthetic biology, bioproducts, and more. Despite its importance in all of these fields, researchers often struggle to understand even the basic mechanisms of protein misfolding. For example, there is no tool to determine how much misfolding is happening inside of any given...
Published: 8/19/2025   |   Inventor(s): Yuichi Eguchi, Kerry Geiler-Samerotte
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors
Rapid Culture-Free Large-Volume Scattering Imaging for UTI Pathogen Detection and Antibiotic Susceptibility Testing
Antibiotic resistance is a significant public health threat, in part due to the misuse and overuse of broad-spectrum antibiotics. Most antimicrobial susceptibility testing (AST) techniques are slow and culture-based, taking days to produce results, which delays treatment and can put patients at risk. Dipstick-type tests and manual microscopy are faster,...
Published: 8/5/2025   |   Inventor(s): Shaopeng Wang, Brandyn Braswell, Jiapei Jiang
Keywords(s):  
Category(s): Diagnostic Assays/Devices, Artificial Intelligence/Machine Learning, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Imaging
Vital Signs Monitoring using Depth Cameras
Cardiovascular disease is responsible for an estimated 17.9 million deaths each year, making it the leading cause of death worldwide. Continuous heart health monitoring way is the best preventative for heart failure. However, standard monitoring devices, including ECG and PPG, require direct physical contact, which can be difficult for certain patient...
Published: 2/13/2025   |   Inventor(s): Yu Rong, Daniel Bliss
Keywords(s):  
Category(s): Computing & Information Technology, Medical Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Imaging
Microfluidic Digital Nanobiosensor for Point-of-Care Detection of NT-proBNP
Heart failure is a serious global burden affecting more than 64 million people worldwide. It has high morbidity and mortality and poor quality of life, making it a major public health priority. N-terminal proBNP (NT-pro-BNP) is a well-established clinical biomarker for monitoring and managing heart failure. Regular and frequent monitoring of patients...
Published: 2/13/2025   |   Inventor(s): Shaopeng Wang, Chao Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices
Label-free Single-molecule Immunoassay Technique
Detection and quantification of low-abundance biomarkers is essential to early disease detection, monitoring and treatment. While many techniques, have been developed for measuring single molecules, all require signal amplification, via enzyme amplification, or fluorescence or gold nanoparticle probes, which come with their own unique drawbacks, including...
Published: 2/13/2025   |   Inventor(s): Shaopeng Wang, Xiaoyan Zhou
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices
Breath-Based Diagnostics for Lower Respiratory Infections
Acute pulmonary infections, or pneumonia, are a leading cause of infectious death worldwide with more than 2.3 million deaths each year. Existing strategies for diagnosing pneumonia are based on clinical, radiological and microbial criteria, which is time-consuming, low accuracy, and subject to interobserver variability. Furthermore, obtaining a lower...
Published: 2/13/2025   |   Inventor(s): Heather Bean, Emily Higgins Keppler
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Diagnostic Assays/Devices
Microfluidic Digital Nanobiosensors for Point-of-Care Detection of Analytes
Detection, identification and quantification of molecular biomarkers, such as proteins, peptides, exosomes, hormones, neurotransmitters, metabolites and nucleic acids, are critical to disease diagnosis, progression monitoring, and management. While there are numerous approaches for analyzing biomarkers, the most validated and well-established is ELISA....
Published: 2/13/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Cancer, Imaging, Life Science (All LS Techs), Medical Devices, Medical Diagnostics/Sensors
Anti-Galectin-1 Monoclonal Antibody
Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...
Published: 6/24/2025   |   Inventor(s): Douglas Lake, Kirsten Pfeffer, Thai Ho
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Tandem Antigen Capture ELISAs for Measuring Short and Long Isoforms of QSOX1
Quiescin sulfhydryl oxidase1 (QSOX1) is a sulfhydryl oxidase that is overexpressed in several malignancies and as such is a potential biomarker for multiple cancer types as well as acute decompensated heart failure (ADHF). Since its discovery, QSOX1 has been identified as a key player in the facilitation of tumor cell migration, creating a significant...
Published: 2/13/2025   |   Inventor(s): Douglas Lake, Thai Ho, Calvin Koelbel
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs)
Optical Imaging Platform for POC CAR T-Cell Therapy Assessment
Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy which uses altered T-cells to target cancer cells more effectively. As such, it has dramatically changed the treatment landscape for cancer patients. However, it has limitations including cytokine release syndrome (CRS), neurological events (NE), lack of response (which occurs...
Published: 2/13/2025   |   Inventor(s): Shaopeng Wang, Nanxi Yu, Chao Chen, Xinyu Zhou, Januario Castro, Eider Moreno Cortes
Keywords(s):  
Category(s): Medical Diagnostics/Sensors, Medical Devices, Life Science (All LS Techs), Imaging, Cancer, Bioanalytical Assays, Chemistries & Devices
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