Search Results - life+sciences+%3e+therapeutics+%3e+small+molecule

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Nanotech for enhanced diagnostic imaging and therapeutic applications
Liposomal J-aggregates of Indocyanine Green are nanoparticles designed for enhanced photoacoustic imaging and photothermal therapy. They offer improved photostability, longer circulation, and efficient heating, hence their promise for diagnostic and therapeutic applications. Background Photoacoustic imaging (PAI) is a promising non-invasive clinical...
Published: 10/21/2024   |   Inventor(s): Tyrone Porter, Noah Stern, James Tunnell, Binita Shrestha
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Imaging
Nanoparticle technology for sustained release of therapeutic agents
This invention describes lipid-based nanoparticles designed for encapsulating and slowly releasing therapeutic agents, such as siRNA, to treat diseases. These nanoparticles enhance drug delivery efficiency and minimize rapid release, improving treatment outcomes and reducing side effects. Background Chronic inflammation-related diseases, such as rheumatoid...
Published: 10/11/2024   |   Inventor(s): Zhengrong Cui, Abdulaziz Aldayel
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Small molecule
A pharmaceutical compound for targeted cancer therapy using nucleobase analog derivatives with omega-3 fatty acids
The invention describes compounds combining nucleobase analogs with omega-3 fatty acids, enhancing cancer treatment efficacy, particularly for pancreatic cancer. These compounds improve stability and solubility and demonstrate significant anti-cancer activity, offering potential for targeted therapy. Background Pancreatic cancer presents a significant...
Published: 9/27/2024   |   Inventor(s): Zhengrong Cui, Dharmika Lansakara
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Biologic
Pegylated aminoglycoside compounds for enhanced treatment of biofilm infections
Pegylated aminoglycoside compounds, like m-PEG-tobramycin, combine antibiotics with polyethylene glycol to enhance solubility, stability, and bioavailability, effectively penetrating and disrupting biofilm infections resistant to standard treatments. Background Biofilm-associated infections present a significant challenge in medical and industrial...
Published: 9/16/2024   |   Inventor(s): Hugh Smyth, Ju Du
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Agriculture > Animal/veterinary
Nasal-based rapid testosterone delivery system
A nasal spray formulation delivers testosterone or its derivatives quickly into the bloodstream via the nasal route, using water, medium-chain triglycerides, and a PEGylated surfactant. This method efficiently treats hypogonadism, low libido, and anxiety disorders . Background Testosterone is a crucial hormone in the human body, playing a significant...
Published: 9/13/2024   |   Inventor(s): Robert Josephs, Craig Herman
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Small molecule
Human enzyme-mediated depletion of serine in cancer
Engineered human serine dehydratase enzymes are designed to efficiently degrade serine, an amino acid crucial to cancer cell metabolism, and inhibit cancer growth. These enzymes, with improved stability, activity, and bio­availability, offer a targeted cancer treatment option with fewer adverse effects. Background Traditional chemotherapeutic...
Published: 8/29/2024   |   Inventor(s): Everett Stone, Ebru Cayir, Daniel Diaz, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Research tools
Advanced PAI contrast agents for early cancer detection
This technology involves creating biodegradable nanoparticles (nanocapsules) that selectively target diseased cells, such as cancer cells, for imaging and treatment. These nanocapsules contain indocyanine green (ICG) dye aggre­gates, which are stable and offer high contrast when using near-infrared photo­acoustic imaging, enabling the detection...
Published: 8/2/2024   |   Inventor(s): Keith Johnston, Thomas Truskett, Ehsan Moaseri, Konstantin Sokolov, Sangheon Han, Behzad Changalvaie
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Therapeutics > Small molecule
Calcium formate as a supplement to prevent neural tube defects
Problem Neural tube defects (NTDs) are devastating birth defects that occur very early during gestation. We now understand that folic acid is crucial for the development of the neural tube, and prenatal vitamin formulations contain additional folic acid to ensure sufficient levels of this important vitamin in women who are pregnant or preparing to...
Published: 12/20/2023   |   Inventor(s): Dean Appling, Jessica Momb
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule
Lung mucus-penetrating peptides
Problem Nucleic acid therapy has the potential to treat genetic diseases that affect the lungs. In order to effectively deliver genetic material to lung cells, gene delivery systems must be able to overcome the mucus barrier and directly target cells harboring the genetic mutation causing the disease state. Past efforts have focused to penetrate the...
Published: 11/5/2024   |   Inventor(s): Debadyuti Ghosh, Melissa Soto
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Drug delivery
Repurposing Tamoxifen to treat lethal E. coli infections
ProblemOver 100,000 people suffer from Shiga toxin-producing E. coli infections every year which cause gastrointestinal illness. In 5% to 15% of cases, these toxins enter the bloodstream, which can result in fatal renal disease. These infections are currently untreatable, as traditional antibiotics induce higher toxin concentrations and worsen illness....
Published: 11/1/2023   |   Inventor(s): Somshuvra Mukhopadhyay, Andrey Selyunin
Keywords(s): Antimicrobials, Digestive disease, Drug development, Drugs, Gastroenterology, Infectious disease, Kidney disease, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Small molecule
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