Search Results - robert+grams

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New approach to fight hormone dependent cancers using covalent inhibition of AKR1C3
Background Aldo-keto reductase family 1 member C3 (AKR1C3) is a key enzyme involved in the metabolism of steroid hormones and prostaglandins, playing a central role in the progression of hormone-dependent cancers such as prostate, breast, and endometrial cancers, as well as in certain inflammatory diseases. Given its pivotal function in these pathologies,...
Published: 7/23/2026   |   Updated: 7/23/2026   |   Inventor(s): Ku-Lung Hsu, Robert Grams
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Small molecule
PhAzE chemistry for selective covalent modification of protein tyrosine and lysine residues
PhAzE chemistry uses cell-permeable phospho-triazole reagents to covalently bond tyrosine and lysine residues in proteins, mimicking natural phosphorylation with low toxicity and tunable reactivity, enabling chiral probe design and potential RNA targeting. Background Covalent chemistry has become a cornerstone of modern chemical biology and drug discovery,...
Published: 6/4/2026   |   Updated: 6/4/2026   |   Inventor(s): Ku-Lung Hsu, Robert Grams
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Formulation